PATHOGENIC MECH IN IDIOPATHIC CHRONIC DIARRHEA OF RH MACAQUES AT THE CNPRC

CNPRC 猕猴特发性慢性腹泻的致病机制

• 批准号: 8357345
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357345
• 关键词: California; Chronic; Development; Diarrhea; Dietary Supplementation; Food Hypersensitivity; Funding; Goals; Grant; Hypersensitivity; Inflammatory; Leucocytic infiltrate; Macaca; Macaca mulatta; National Center for Research Resources; Prevention; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Therapeutic; United States National Institutes of Health; Zinc; commensal microbes; cost; enteric pathogen; health economics; soluble fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Chronic idiopathic diarrhea (ICD) is a major health and economic problem in the management of rhesus monkeys in captivity. The pathogenic mechanism(s)underlying this condition have not been well studied beyond histological characterization of the colonic inflammatory cellular infiltrate in the absence of recognized enteric pathogens. The goal of this project is to systematically investigate potential pathogenetic mechanisms, including food hypersensitivity, hypersensitivity to normal gut commensal bacteria, and irregularities in composition of colonic microflora (dysbiosis), in the development of this condition. This project will also investigate the therapeutic potential of dietary supplementation with zinc and/or soluble fiber in the treatment and prevention of ICD.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 慢性特发性腹泻（ICD）是囚禁恒河猴管理的主要健康和经济问题。 在没有公认的肠道病原体的情况下，尚未对这种情况的致病机制（S）进行过很好的研究。 该项目的目的是系统地研究潜在的致病机制，包括过敏性，对正常肠道共生细菌的高敏性和结肠菌群组成的不规则性（失调），在这种情况的发展中。该项目还将研究在ICD治疗和预防中用锌和/或可溶性纤维补充饮食的治疗潜力。