PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES

纯种 SPF 恒河猴的生产

• 批准号: 8357244
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357244
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Breeding; California; Censuses; Cercopithecine Herpesvirus 1; Funding; Grant; Institution; MHC Class I Genes; Macaca mulatta; National Center for Research Resources; Primates; Principal Investigator; Production; Research; Research Infrastructure; Research Personnel; Resources; SIV; Simian Foamy Virus; Source; Specific Pathogen Frees; Type D Retrovirus; United States National Institutes of Health; Virus; Virus Diseases; cost; genetic pedigree; germ free condition; offspring

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is a continuing need for rhesus macaques of Indian-ancestry that are free of specific pathogens, particularly persistent viral infections, for use in AIDS-related research. We have successfully established and maintained a long-term breeding colony of SPF, genetically characterized Indian origin rhesus macaques. The current colony census is 302 animals. To date, 148 animals produced in this colony have been made available to AIDS researchers at various institutions. Animals produced in this colony are SPF for Cercopithecine herpesvirus 1 (CHV1), simian type D retrovirus (SRV), simian immunodeficiency virus (SIV), simian T- lymphotropic Virus (STLV) and simian foamy virus (SFV). All animals are of known pedigree and geographic origin. Offspring produced are also haplotyped for several MHC class I (Mamu A*01, A*02, A*08, B*01, B*17) and class II (DPB, DQA, DQB) loci.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 持续需要的印度疗法猕猴没有特定的病原体，尤其是持续的病毒感染，用于与艾滋病相关的研究中。我们已经成功建立并维持了SPF的长期繁殖菌落，具有遗传学特征的印度恒河猕猴。当前的菌落普查是302只动物。迄今为止，该殖民地生产的148种动物已向各个机构的艾滋病研究人员提供。 该菌落中产生的动物是用于cercopithecine疱疹病毒1（CHV1），D型D型逆转录病毒（SRV），Simian免疫缺陷病毒（SIV），Simian T-淋巴细胞性病毒（STLV）和Simian Foamy Virus（SFV）的SPF。所有动物都是已知的 血统和地理起源。对于几个MHC I类（MAMU A*01，A*02，A*08，B*01，B*17）和II类（DPB，DQA，DQB）基因座，也对产生的后代进行了单型。