PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES: AIDS

纯种 SPF 恒河猴的生产：艾滋病

• 批准号: 8356902
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 122.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356902
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Birth; Breeding; Cercopithecine Herpesvirus 1; Cytomegalovirus; Derivation procedure; Funding; Genotype; Goals; Grant; Infant; Macaca mulatta; Mothers; National Center for Research Resources; Nurseries; Principal Investigator; Production; Research; Research Infrastructure; Resources; Rhadinovirus; SIV; Simian Foamy Virus; Source; Specific Pathogen Frees; Type D Retrovirus; United States National Institutes of Health; Viral; Viral Pathogenesis; Virus; cost; genetic pedigree; germ free condition; public health relevance; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required. PUBLIC HEALTH RELEVANCE (provided by applicant): The rhesus monkeys produced as part of this grant will provide valuable resources for AIDS-related research. These animals will be used for research related to viral pathogenesis, vaccine development and anti-viral therapy.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine疱疹病毒1（b病毒），猿猴泡沫病毒（SFV），恒河猴（Rhcmv）和恒河猴rhadinovirus（RRV）。该拟议的扩张将用于生产SPF动物，用于与AIDS相关的研究中，并建立具有印度恒河猕猴的长期自我维持的SPF繁殖菌落，并具有已知的谱系和明确定义的MHC基因型。现在，这个殖民地超过了350只动物，并通过SPF母亲的自然出生和饲养自我维持。不再需要通过传统育种者出生的婴儿养育育苗的SPF育种者的推导。 公共卫生相关性（由申请人提供）：作为本赠款的一部分生产的恒河猴将为与艾滋病相关的研究提供宝贵的资源。这些动物将用于与病毒发病机理，疫苗发育和抗病毒疗法有关的研究。