Behavioral and Neural Response to Cocaine Cue-Reactivity

对可卡因提示反应的行为和神经反应

• 批准号: 8385869
• 负责人: DAVID A SMELSON
• 金额: $ 23.92万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8385869
• 关键词: Amygdaloid structure; Anterior; Architecture; Area; Behavior; Behavior Control; Behavior Therapy; Behavioral; Biological Neural Networks; Brain; Cade; Candidate Disease Gene; Clinical; Clinical Treatment; Clinical assessments; Cocaine; Cognitive; Cues; Data; Data Collection; Dependence; Dopamine; Dorsal; Drug usage; Functional Magnetic Resonance Imaging; Genetic Polymorphism; Goals; Individual; Individual Differences; Intervention; Laboratories; Lateral; Link; Literature; Measures; Neurophysiology - biologic function; Outcome; Patient Self-Report; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Pilot Projects; Prefrontal Cortex; Procedures; Relapse; Reporting; Research; Research Personnel; Retinal Cone; Risk; Role; Severities; Stimulus; Subgroup; Substance of Abuse; Testing; Ventral Striatum; Visual; Vulnerable Populations; War; Work; addiction; base; clinically relevant; cocaine exposure; cognitive control; cost; craving; cue reactivity; drug craving; improved; indexing; innovation; neuroimaging; psychosocial; relating to nervous system; research study; response; tool; treatment planning; visual stimulus

DESCRIPTION (provided by applicant): Cocaine dependent (CD) subjects demonstrate great variability in response to cocaine cues presented in laboratory settings. Recognizing the clinical relevance, researchers have further examined this variability. Approximately half of CD subjects display changes in self report craving and the other half show little or no response. We have previously termed these groups high and low cue-reactive, respectively. This proposed exploratory I/START will move beyond documenting differences in high and low cue-reactivity via self report craving to objectively examining the consequences on cognitive control in response to drug and neutral cues using a modified antisaccade task, and fMRI to explore corresponding neural networks involved in cognitive control over cue-elicited behavior. This project is consistent with the I/START goals of pilot data collection, while also enabling Dr. Smelson to develop expertise in neuroimaging to enhance his research in drug craving, and expanding Dr. DiGirolamo's expertise in behavioral control and neuroimaging into the field of addiction. This project investigates the following Aims: 1. To examine differences in cognitive control toward cocaine cues based on differences in higher and lower cue reactivity; and 2. To evaluate neuroanatomical activation differences in cognitive control toward cocaine cues in high and low cue-reactive cocaine-dependent patients. Sixty-eight CD subjects will have a baseline cue-exposure procedure, followed by a modified antisaccade task to answer Aim 1. A subgroup of 24 subjects (12 high and 12 low cue- reactive individuals) will then undergo a second modified antisaccade task during fMRI to test Aim 2. This project will innovatively link a subjective measure of cue-reactivity (i.e., self-report craving) with objective measures of cognitive control via a modified antisaccade task and neural activation via fMRI. This work will clarify whether higher cue-reactive subjects display worse cognitive control to cocaine cues while examining the corresponding neural differences when attempting to control cue-elicited behavior. Future research directions of this proposed work will focus on whether higher reactive patients are more vulnerable to relapse, and have a differential response to pharmacological and psychosocial interventions targeting cue-elicited reactivity and control over cue-elicited behavior. This research will also assist in further establishing these paradigms for routine use in clinical assessment and treatment planning. PUBLIC HEALTH RELEVANCE: Cocaine craving is considered an important component of ongoing use, but its role in predicting relapse remains unclear. This research study has broad implications for further substantiating cue-exposure and the antisaccade task as clinical tools to identify patients with high craving, poor control over behavior, and thus, greater risk for relapse

描述（由申请人提供）：可卡因依赖（CD）受试者对实验室环境中出现的可卡因提示表现出巨大的反应差异。认识到临床相关性，研究人员进一步研究了这种变异性。大约一半的CD受试者表现出自我报告渴望的变化，而另一半则表现出很少或没有反应。我们之前分别将这些群体称为高线索反应性和低线索反应性。这个拟议的探索性 I/START 将超越通过自我报告渴望记录高和低线索反应性的差异，客观地检查认知控制对药物和中性线索的影响，使用修改后的反眼跳任务和功能磁共振成像来探索相应的神经网络参与对线索引发的行为的认知控制。该项目符合 I/START 试点数据收集的目标，同时也使 Smelson 博士能够发展神经影像学方面的专业知识，以加强他对药物渴望的研究，并将 DiGirolamo 博士在行为控制和神经影像学方面的专业知识扩展到成瘾领域。该项目研究以下目标： 1. 根据较高和较低提示反应性的差异，检查对可卡因提示的认知控制差异； 2. 评估高和低线索反应性可卡因依赖患者对可卡因线索认知控制的神经解剖学激活差异。 68 名 CD 受试者将接受基线提示暴露程序，然后进行修改后的反眼跳任务来回答目标 1。然后，由 24 名受试者组成的小组（12 名高提示反应个体和 12 名低提示反应个体）将在fMRI 来测试目标 2。该项目将创新性地通过改进的方法将提示反应性的主观测量（即自我报告渴望）与认知控制的客观测量联系起来。通过功能磁共振成像进行反眼跳任务和神经激活。这项工作将阐明较高的线索反应性受试者是否对可卡因线索表现出较差的认知控制，同时检查在尝试控制线索引发的行为时相应的神经差异。这项拟议工作的未来研究方向将集中于反应性较高的患者是否更容易复发，以及对针对线索引发的反应性和对线索引发的行为的控制的药理学和心理社会干预措施有不同的反应。这项研究还将有助于进一步建立这些范式以供日常使用 临床评估和治疗计划。 公共卫生相关性：对可卡因的渴望被认为是持续使用可卡因的一个重要组成部分，但其在预测复发方面的作用仍不清楚。这项研究对于进一步证实线索暴露和抗眼跳任务作为临床工具来识别具有高渴望、行为控制能力差以及因此复发风险更大的患者具有广泛的意义

项目成果

Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder.

• DOI: 10.1080/15504263.2017.1360535
• 发表时间: 2017-10
• 期刊: Journal of dual diagnosis
• 影响因子: 2.2
• 作者: DiGirolamo GJ;Gonzalez G;Smelson D;Guevremont N;Andre MI;Patnaik PO;Zaniewski ZR
• 通讯作者: Zaniewski ZR