Behavioral and Neural Response to Cocaine Cue-Reactivity

对可卡因提示反应的行为和神经反应

• 批准号: 8385869
• 负责人: DAVID A SMELSON
• 金额: $ 23.92万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8385869
• 关键词: Amygdaloid structure; Anterior; Architecture; Area; Behavior; Behavior Control; Behavior Therapy; Behavioral; Biological Neural Networks; Brain; Cade; Candidate Disease Gene; Clinical; Clinical Treatment; Clinical assessments; Cocaine; Cognitive; Cues; Data; Data Collection; Dependence; Dopamine; Dorsal; Drug usage; Functional Magnetic Resonance Imaging; Genetic Polymorphism; Goals; Individual; Individual Differences; Intervention; Laboratories; Lateral; Link; Literature; Measures; Neurophysiology - biologic function; Outcome; Patient Self-Report; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Pilot Projects; Prefrontal Cortex; Procedures; Relapse; Reporting; Research; Research Personnel; Retinal Cone; Risk; Role; Severities; Stimulus; Subgroup; Substance of Abuse; Testing; Ventral Striatum; Visual; Vulnerable Populations; War; Work; addiction; base; clinically relevant; cocaine exposure; cognitive control; cost; craving; cue reactivity; drug craving; improved; indexing; innovation; neuroimaging; psychosocial; relating to nervous system; research study; response; tool; treatment planning; visual stimulus

DESCRIPTION (provided by applicant): Cocaine dependent (CD) subjects demonstrate great variability in response to cocaine cues presented in laboratory settings. Recognizing the clinical relevance, researchers have further examined this variability. Approximately half of CD subjects display changes in self report craving and the other half show little or no response. We have previously termed these groups high and low cue-reactive, respectively. This proposed exploratory I/START will move beyond documenting differences in high and low cue-reactivity via self report craving to objectively examining the consequences on cognitive control in response to drug and neutral cues using a modified antisaccade task, and fMRI to explore corresponding neural networks involved in cognitive control over cue-elicited behavior. This project is consistent with the I/START goals of pilot data collection, while also enabling Dr. Smelson to develop expertise in neuroimaging to enhance his research in drug craving, and expanding Dr. DiGirolamo's expertise in behavioral control and neuroimaging into the field of addiction. This project investigates the following Aims: 1. To examine differences in cognitive control toward cocaine cues based on differences in higher and lower cue reactivity; and 2. To evaluate neuroanatomical activation differences in cognitive control toward cocaine cues in high and low cue-reactive cocaine-dependent patients. Sixty-eight CD subjects will have a baseline cue-exposure procedure, followed by a modified antisaccade task to answer Aim 1. A subgroup of 24 subjects (12 high and 12 low cue- reactive individuals) will then undergo a second modified antisaccade task during fMRI to test Aim 2. This project will innovatively link a subjective measure of cue-reactivity (i.e., self-report craving) with objective measures of cognitive control via a modified antisaccade task and neural activation via fMRI. This work will clarify whether higher cue-reactive subjects display worse cognitive control to cocaine cues while examining the corresponding neural differences when attempting to control cue-elicited behavior. Future research directions of this proposed work will focus on whether higher reactive patients are more vulnerable to relapse, and have a differential response to pharmacological and psychosocial interventions targeting cue-elicited reactivity and control over cue-elicited behavior. This research will also assist in further establishing these paradigms for routine use in clinical assessment and treatment planning. PUBLIC HEALTH RELEVANCE: Cocaine craving is considered an important component of ongoing use, but its role in predicting relapse remains unclear. This research study has broad implications for further substantiating cue-exposure and the antisaccade task as clinical tools to identify patients with high craving, poor control over behavior, and thus, greater risk for relapse

描述（由申请人提供）：可卡因依赖性（CD）受试者表现出对实验室环境中提出的可卡因提示的巨大变化。认识到临床相关性，研究人员进一步研究了这种变异性。大约一半的CD受试者显示自我报告渴望的变化，而另一半显示几乎没有反应。我们先前分别称这些组分别为高和低提示反应性。这项提出的探索性I/开始将超越记录高线索反应性的差异，通过自我报告渴望客观地检查对药物控制的后果，以响应药物和中性提示，并使用改良的反accade任务和FMRI探索探索相应的神经网络涉及的神经网络，涉及提示性控制的认知能力控制。该项目与试点数据收集的I/起始目标一致，同时还使Smelson博士能够在神经影像方面发展专业知识，以增强他在药物渴望方面的研究，并扩大了Digirolamo博士在行为控制方面的专业知识，并将神经影像学在成瘾领域中。该项目研究了以下目的：1。基于较高和较低的提示反应性的差异，检查认知控制对可卡因提示的差异；和2。评估在高和低提示性可卡因依赖性患者中对可卡因线索的认知对照中的神经解剖激活差异。六十八CD受试者将采用基线提示曝光程序，然后进行修改的反检测任务，以回答目标1。然后，由24个受试者（12个高和12个低提示性的个体）组成的子组将在FMRI期间进行第二次修改的反accad任务，以测试目标2。通过fMRI修改的反扫视任务和神经激活的认知控制。这项工作将阐明较高的提示反应受试者是否在尝试控制提示引诱的行为时检查相应的神经差异时，是否对可卡因提示表现出较差的认知控制。这项拟议工作的未来研究方向将集中于更高的反应性患者是否更容易发生复发，并且对针对提示引诱的反应性的药理和社会心理干预措施产生了不同的反应，并控制了提示引用的行为。这项研究还将有助于进一步建立这些常规使用的范例 临床评估和治疗计划。 公共卫生相关性：可卡因渴望被认为是持续使用的重要组成部分，但其在预测复发中的作用尚不清楚。这项研究对进一步证实提示暴露和反扫视任务具有广泛的影响

项目成果

Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder.

• DOI: 10.1080/15504263.2017.1360535
• 发表时间: 2017-10
• 期刊: Journal of dual diagnosis
• 影响因子: 2.2
• 作者: DiGirolamo GJ;Gonzalez G;Smelson D;Guevremont N;Andre MI;Patnaik PO;Zaniewski ZR
• 通讯作者: Zaniewski ZR