Qigong Therapy for Treating Cocaine Addiction

气功疗法治疗可卡因成瘾

• 批准号: 7222798
• 负责人: DAVID A SMELSON
• 金额: $ 6.16万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2008-04-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222798
• 关键词: Abstinence; Acupuncture procedure; Acute; Aftercare; Alcohol or Other Drugs use; American; Anxiety; Applications Grants; Area; Belief; Cessation of life; Clinical Trials; Clinical effectiveness; Cocaine; Cocaine Dependence; Cocaine Users; Control Groups; Controlled Clinical Trials; Cues; Data; Double-Blind Method; Dropout; Duct (organ) structure; Effectiveness; Expectancy; Funding; Future; Grant; Head; Health Personnel; Heroin; Incidence; Intervention; Investigation; Laboratories; Life; Light; Mental Depression; Methodology; Modeling; National Institute of Drug Abuse; Numbers; Outcome; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Placebo Control; Placebos; Procedures; Qi; Qi Gong; Randomized; Randomized Controlled Clinical Trials; Rate; Recovery; Relapse; Religion and Spirituality; Research Personnel; Role; Sample Size; Score; Severities; Study models; Substance Abuse, Other; Symptoms; Testing; Toxicology; Treatment outcome; Tweens; United States Substance Abuse and Mental Health Services Administration; Urine; Week; Withdrawal; addiction; aged; base; concept; craving; data management; day; double-blind placebo controlled trial; experience; follow-up; improved; indexing; programs; response; sobriety; success; tool; young adult

DESCRIPTION (provided by applicant): This revised R21 grant application (1R21AT001350-01A1) was previously submitted in October, 2003, to perform a randomized double-blind placebo-controlled trial to investigate external Qigong therapy (EQT) in reducing cue-elicited craving and improving treatment outcome in withdrawn cocaine dependent patients. The specific aims of the study include: (1) Examining the efficacy of EQT for reducing cue-elicited cocaine craving in acutely abstinent cocaine dependent subjects; (2) Investigating the effect of EQT on reducing symptoms of anxiety and depression associated with acute withdrawal; (3) Investigating the effect of EQT on reducing substance use and the incidence of addiction-related problems; and (4) Testing whether the benefits of EQT are independent of the perceived credibility of EQT and the expectancy one has of experiencing positive treatment outcomes. These aims will be achieved through a trial with 98 cocaine dependent subjects who will be randomly assigned to either a Qigong treated group or a Sham treated control group. Qigong treatment consists of "Qi emission" by the Qigong Master toward the head area for a total of six 10-minute sessions over 2 weeks. EQT effectiveness in reducing craving will be determined using a cue-elicited craving paradigm. This involves a set of highly standardized and safe procedures for inducing craving in a controlled laboratory setting by exposing subjects to cocaine-related and neutral non-drug related cues. The present researchers have employed this methodology in clinical trials to screen anti-craving medications for cocaine addiction for the past 8 years. In addition to the two-week laboratory model, this study will also examine the efficacy of Qigong for reducing anxiety and depression associated with acute withdrawal, increasing sobriety, and improving substance use and related problems identified on the Addiction Severity Index. Finally, we will examine whether the subject's belief in treatment has an effect on treatment outcomes. The pilot data collected through this R21 grant will serve as a basis for future R01 applications to examine Qigong efficacy in improving craving and treatment outcome for cocaine addiction.

DESCRIPTION (provided by applicant): This revised R21 grant application (1R21AT001350-01A1) was previously submitted in October, 2003, to perform a randomized double-blind placebo-controlled trial to investigate external Qigong therapy (EQT) in reducing cue-elicited craving and improving treatment outcome in withdrawn cocaine dependent patients.该研究的具体目的包括：（1）检查eqt在急性戒酒可卡因受试者中降低提示吸引的可卡因的效力； （2）研究EQT对减少与急性戒断有关的焦虑和抑郁症状的影响； （3）研究EQT对减少物质使用的影响和与成瘾有关的问题的发生； （4）测试EQT的好处是否独立于EQT的可信度以及人们经历积极治疗结果的期望。这些目标将通过与98位可卡因依赖性受试者进行试验来实现，这些受试者将随机分配到一个气功治疗组或假治疗对照组。气功治疗包括气功大师向头部区域的“ Qi排放”组成，在2周内总共进行了六个10分钟的课程。 EQT在降低渴望中的有效性将使用提示吸引的渴望范式确定。这涉及一组高度标准化和安全的程序，用于通过暴露于与可卡因相关的和中性的非药物相关线索的受试者来诱导受控实验室环境中的渴望。目前的研究人员在临床试验中采用了这种方法来筛选过去8年来筛选可卡因成瘾的药物。除了为期两周的实验室模型外，这项研究还将检查气功对减少与急性戒断相关的焦虑和抑郁症的功效，提高清醒，改善药物使用以及在成瘾严重程度指数上发现的相关问题。最后，我们将研究受试者对治疗的信念是否对治疗结果有影响。通过此R21赠款收集的试点数据将作为未来R01应用程序的基础，以检查气功效力，以改善可卡因成瘾的渴望和治疗结果。