Cue-Elicited Craving /Genetics in Relapse in Cocaine Use

可卡因吸食复发中的提示引发的渴望/遗传学

• 批准号: 7011912
• 负责人: DAVID A SMELSON
• 金额: $ 7.78万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7011912
• 关键词: African American; behavioral /social science research tag; behavioral genetics; clinical research; cocaine; craving; cues; dopamine receptor; drug addiction; endorphins; genetic polymorphism; genetic screening; human subject; interview; longitudinal human study; male; neuropeptide receptor; neurotransmitter receptor; polymerase chain reaction; receptor expression; relapse /recurrence; single nucleotide polymorphism; substance abuse related behavior; urinalysis

DESCRIPTION (provided by applicant): This R03 grant application, submitted in response to RFA-DA-05-004 "Lapse and Relapse to Drug Abuse and Other Chronic Conditions," proposes an interdisciplinary project with collaborations between clinical and basic scientists to examine the roles of cue-reactivity and genetic polymorphisms as possible etiological mechanisms in the relapse to cocaine use. This represents one of the few studies of relapse in human populations to combine laboratory-based measures with community-based follow-up to understand the biological and behavioral foundations of relapse to cocaine. The specific aims of the study are to: (1) examine whether drug-free cocaine dependent cue-reactive individuals are more likely to relapse than nonreactive individuals; (2) determine whether cue-elicited craving responses are significantly different in cocaine dependent individuals with polymorphisms in candidate genes in the dopamine and beta-endorphin pathways compared to individuals without the polymorphisms; and (3) determine whether individuals with genetic polymorphisms are more likely to relapse with cocaine than those without the genetic polymorphisms. This proposed project will be an "add-on" to an existing five-year Center for Substance Abuse Treatment grant (CSAT) awarded to Drs. Smelson and Kline and funded through 2009. The CSAT grant targets 550 individuals with a substance abuse disorder entering treatment at the Department of Veterans Affairs New Jersey Health Care System (VANJ). This proposed R03 will recruit a subgroup of 105 African American males with a confirmed diagnosis of cocaine dependence who are enrolled in the CSAT project. Those recruited into this R03 study will undergo a baseline assessment battery, cue-exposure procedure, blood withdrawal for genetic analysis, and urine toxicology screening. The subjects will be reassessed with the Addiction Severity Index and urine toxicology screen at six months post-baseline through the CSAT project to determine relapse to cocaine. This project represents a broad exploratory transdisciplinary effort to better understand the clinical, behavioral and biological bases of relapse and will serve as the foundation for a future R01 submission. This study will help further our understanding of the mechanisms underlying relapse to cocaine and lead to the development of more effective relapse prevention strategies and pharmacogenetic treatments.

描述（由申请人提供）：此R03授予申请，响应RFA-DA-05-004“失效和复发到药物滥用和其他慢性病状况”，提出了一个跨学科项目，与临床科学家之间的合作和基本科学家之间的协作，以检查提示反应性和遗传性多态性的作用，并可能使用遗传学机制，以实现cocainsy机制。这代表了人类种群复发的少数研究之一，将基于实验室的措施与基于社区的随访相结合，以了解复发的生物学和行为基础。该研究的具体目的是：（1）检查与非反应性个体相比，无类依赖的可卡因反应性个体是否更有可能复发； （2）确定与没有多态性的个体相比，在多巴胺和β-内啡肽途径的候选基因中，可卡因依赖性的个体中有多态性的可卡因依赖人的渴望反应是否显着差异。 （3）确定患有遗传多态性的个体是否比没有遗传多态性的人更可能与可卡因复发。该提议的项目将是授予DRS的现有五年药物滥用治疗赠款（CSAT）的“附加”。 Smelson and Kline并于2009年提供资金。CSAT赠款针对550名患有药物滥用障碍的人进入新泽西州医疗保健系统（VANJ）的治疗。该提议的R03将招募一个由105名非裔美国人男性组成的子组，并确认诊断为可卡因依赖性，他们已入学。这项R03研究中招募的人将接受基线评估电池，提示曝光程序，提取遗传分析和尿液毒理学筛查。通过CSAT项目，六个月后，对受试者的成瘾严重程度指数和尿液毒理学筛查将重新评估，以确定对可卡因的复发。该项目代表了广泛的探索性跨学科努力，以更好地了解复发的临床，行为和生物学基础，并将作为未来R01提交的基础。这项研究将有助于我们进一步理解可卡因的复发机制，并导致开发更有效的预防复发策略和药物遗传治疗。