The Effect of Acoustic Enhancement of Slow-Wave Activity on Cognitive Control and Emotional Reactivity in Young Adults with Anxiety and Depression Symptoms

慢波活动的声学增强对患有焦虑和抑郁症状的年轻人的认知控制和情绪反应性的影响

• 批准号: 10678866
• 负责人: Michelle Elizabeth Stepan
• 金额: $ 17.47万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678866
• 关键词: Acoustic Stimulation; Acoustics; Affective; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Arousal; Aversive Stimulus; Behavior assessment; Brain; Clinical; Cognitive; Coupling; Crossover Design; Development; Devices; Diagnostic; Dorsal; Electroencephalography; Emotional; Female; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health behavior; Image; Individual; Inferior; Insula of Reil; Investigational Therapies; Knowledge; Measures; Mental Depression; Mental Health; Mental disorders; Mentorship; Modeling; Mood Disorders; National Institute of Mental Health; Neuronal Plasticity; Onset of illness; Outcome; Parietal Lobe; Participant; Patient Self-Report; Patient-Focused Outcomes; Performance; Physiological; Play; Polysomnography; Positioning Attribute; Predictive Factor; Prefrontal Cortex; Preventive treatment; Principal Investigator; Process; Psychiatry; REM Sleep; Randomized; Recording of previous events; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Schedule; Science; Scientist; Sleep; Sleep Architecture; Sleep Stages; Sleep disturbances; Slow-Wave Sleep; Synapses; Techniques; Testing; Thalamic structure; Therapeutic; Training; Training Activity; Universities; Work; adequate sleep; affective neuroscience; anxiety symptoms; career; cingulate cortex; cingulate gyrus; circadian; cognitive control; cognitive process; comorbidity; density; depressive symptoms; disorder prevention; emotion regulation; experience; improved; information processing; innovation; medical schools; negative affect; neural circuit; neurobehavioral; primary outcome; programs; skills; sleep health; therapeutic target; treatment of anxiety disorders; young adult

PROJECT SUMMARY/ABSTRACT Anxiety and mood disorders are the most common psychiatric conditions. They are also highly comorbid, and co-occurrence is associated with worse patient outcomes. Neurobehavioral dysfunction in cognitive control and emotional reactivity are considered fundamental mechanisms of disorder onset and progression. To inform effective preventative treatments, it is critical to identify modifiable factors that directly impact these transdiagnostic processes. Sleep is one such factor. The deepest stage of sleep, slow-wave sleep, is consistently reduced in most psychiatric conditions and can be modified using a variety of techniques. Slow-wave sleep predominates over the prefrontal cortex, providing particular benefit to cognitive processes, including cognitive control. Cognitive control is instrumental in downregulating negative affect to aversive stimuli. The aim of the current study is to elucidate the role of slow-wave sleep in cognitive control and emotional reactivity to aversive stimuli. We will study 40 young adults with elevated anxiety and depression symptoms and sleep disturbance. Participants will complete two overnights in our sleep lab with polysomnography to assess sleep architecture. Participants will also wear an acoustic stimulation device to enhance slow-wave sleep. During one of the overnights, the device will play sub-arousal tones to boost slow-wave sleep; during the other overnight, tone volume will be zero. The day after each overnight, participants will complete assessments of cognitive control and emotional reactivity in an fMRI scanner. We will examine effects of acoustic enhancement of slow-wave sleep on neurobehavioral measures of cognitive control and emotional reactivity and whether improvements in emotional reactivity occur through cognitive control improvements. This study will elucidate sleep-based mechanisms of anxiety and mood disorder onset in an at-risk sample and inform innovative, targeted, accessible sleep preventative treatments. The candidate possesses skills in sleep manipulation, polysomnography, and assessment of cognitive processes to conduct the proposed research. With additional critical training in 1) advanced targeted sleep manipulation and sleep EEG spectral analysis, 2) cognitive-affective neuroscience and fMRI, and 3) clinical knowledge and treatment of anxiety and mood disorders, the Principal Investigator will obtain the skills necessary to develop an independent research program focused on sleep and mental health. Training and research activities for the current proposal will be completed at the University of Pittsburgh School of Medicine. The Department of Psychiatry and the Center for Sleep and Circadian Science are leaders in sleep and mental health research and devoted to the professional development of early career scientists. The candidate has assembled a mentorship team of experienced independent researchers and clinicians with expertise in the proposed research aims and a successful history of mentorship. The intellectual and material resources provided by the University of Pittsburgh, combined with the proposed mentorship team’s guidance strongly position the candidate to achieve her proposed training, research, and career goals.

项目摘要/摘要 焦虑和情绪障碍是最常见的精神病。他们也很合并 同时出现与较差的患者结局有关。认知控制中的神经行为功能障碍 情绪反应性被认为是无序发作和进展的基本机制。告知 有效的预防性治疗，至关重要的是，确定直接影响这些的可修改因素 转诊过程。睡眠就是这样的因素之一。最深的睡眠阶段，慢波睡眠，始终是 在大多数精神病疾病中降低，可以使用多种技术进行修改。慢波睡觉 主要是前额叶皮层，为认知过程提供了特殊的好处，包括认知 控制。认知控制对下调对厌恶刺激的负面影响有用。目的 当前的研究是阐明慢波睡眠在认知控制中的作用和对厌恶性的情感反应性 刺激。我们将研究40名动画和抑郁症状和睡眠障碍的年轻人。 参与者将在我们的睡眠实验室中完成两个通宵，以评估睡眠体系结构。 参与者还将佩戴声学刺激装置，以增强慢波睡眠。在一个 一夜之间，该设备将播放底声音调以增强慢波睡眠。在另一个一夜之间，音调 音量为零。每个过夜后的第二天，参与者将完成认知控制的评估 和fMRI扫描仪中的情感反应性。我们将检查慢波的声学增强的影响 睡在神经行为的认知控制和情绪反应性的措施以及是否改善 情绪反应通过认知控制的改善发生。这项研究将阐明基于睡眠的 处于危险样本中的焦虑和情绪障碍的机制，并为创新，有针对性，可访问提供信息 睡眠预防治疗。候选人具备睡眠操纵，多渗透学和 评估认知过程以进行拟议的研究。在1中进行额外的关键培训） 先进的靶向睡眠操纵和睡眠脑EEG光谱分析，2）认知影响神经科学和 fMRI和3）动画和情绪障碍的临床知识和治疗，首席研究员将 获得开发针对睡眠和心理健康的独立研究计划所需的技能。 当前建议的培训和研究活动将在匹兹堡大学完成 医学。精神病学系和睡眠和昼夜科学中心是睡眠的领导者 和心理健康研究，并致力于早期职业科学家的专业发展。 候选人已经组建了一个由经验丰富的独立研究人员和临床医生组成的心态团队 拟议的研究目的和成功的心态历史方面的专业知识。智力和材料 匹兹堡大学提供的资源以及拟议的Mentalship团队的指导结合 强烈定位候选人，以实现她提出的培训，研究和职业目标。