Advancing a Bio-Psycho-Social Alcohol Treatment Research and Mentoring Program

推进生物心理社会酒精治疗研究和指导计划

• 批准号: 8321083
• 负责人: PETER M. MONTI
• 金额: $ 23.79万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321083
• 关键词: ARHGEF5 gene; Abstinence; Address; Admission activity; Adverse effects; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Applications Grants; Area; Award; Behavioral Mechanisms; Benefits and Risks; Clinical; Communities; Complement; Consumption; Data; Data Set; Development; Disclosure; Dose; Early treatment; Environment; Epidemiologist; Equilibrium; Event; Faculty; Feedback; Funding; Gender; Genetic; Goals; Grant; HIV; Head; Hospitals; Individual; Individual Differences; Injury; Intervention; Intervention Studies; K-Series Research Career Programs; Laboratories; Laboratory Study; Learning; Left; Magnetic Resonance Imaging; Manuscripts; Measures; Mediating; Mediator of activation protein; Medical; Mentors; Mentorship; Modality; Motivation; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Neurosciences; Outcome Assessment; Palm-Top Computers; Paper; Participant; Patient Self-Report; Patients; Pattern; Personal Digital Assistant; Pharmacological Treatment; Pharmacotherapy; Phase; Placebo Control; Placebos; Population; Positioning Attribute; Probability; Procedures; Psychologist; Public Health; Publications; Publishing; Qualifying; Randomized; Readiness; Records; Recruitment Activity; Reporting; Research; Research Design; Research Personnel; Risk; Sampling; Scientist; Self Efficacy; Senior Scientist Award; Severities; Site; Social support; Time; Titrations; Trauma; Treatment Efficacy; Treatment outcome; Universities; Visit; Wages; Woman; Work; Youth; abstracting; addiction; adolescent alcohol; alcohol abuse therapy; alcohol craving; alcohol effect; alcohol intervention; alcohol related problem; alcohol research; alcohol response; attenuation; base; behavioral/social science; biobehavior; biopsychosocial; brief intervention; career; contextual factors; cost; craving; cue reactivity; design; drinking; drinking behavior; experience; high risk; improved; interest; men; motivational enhancement therapy; problem drinker; professor; programs; public health relevance; reduced alcohol use; response; skills; social; standard care; topiramate; trauma centers; trauma units; treatment response; young adult

DESCRIPTION (provided by applicant): This is a new application for a Senior Research and Mentorship Award (K05). The candidate, Peter M. Monti, Distinguished Professor of Alcohol and Addiction Studies, Director, Center for Alcohol and Addiction Studies and Head of the Behavioral and Social Sciences Section at Brown University, proposes an initial period of intense research mentoring to four outstanding Brown University scientists in his Center and a shift in his research program to youth and young adults. Therefore, Dr. Monti proposes to transition from a VA Senior Career Scientist Award to the K05. Mentees and Mentoring Plan. One of the proposed mentees, Don Operario (a social psychologist) was recently recruited from Oxford University and is in a tenure-track position. The other two proposed faculty mentees, Robert Miranda (a clinical psychologist) and Tara White (a neuroscientist) are on a "research" track. While all three have excellent publication records, only Miranda has published alcohol papers and has received funding from NIAAA (a K23 and 2 R21s). Operario and White are NIDA-funded. None have been funded at the R01 level from NIAAA, though all three have demonstrated strong interest in becoming alcohol researchers. Miranda is furthest along, though both Operario and White have submitted alcohol applications as part of the candidate's pending P60 Center Grant Proposal. The fourth mentee, Margie Skeer (a social epidemiologist) is a postdoctoral candidate working with Monti. She too has a strong publication record. However, she has only just published her first alcohol manuscript, though she has indicated interest in alcohol, as this was her reason for coming to Brown. Mentoring goals for all applicants involve providing both targeted and general guidance and support for grantsmanship, the development of alcohol research programs, and more general professional development issues including feedback on how to mentor their own trainees. Importantly, all four mentees have been incorporated into the applicant's research program which is moving in the direction of youth alcohol intervention and the study of alcohol/HIV interactions. The applicant intends to gain complementary expertise in this area as well as in neuroscience and MRI modalities - all topics of his P60. With respect to the Research Plan, the applicant intends to continue to focus on a research agenda that is broad and yet focused on treatment mechanisms, pharmacotherapy, contextual factors and individual differences. Using his existing data sets he proposes to study mediators and moderators of treatment outcomes and the assessment of daily drinking behavior in the context of his brief intervention work. In addition he will add a study of lab-based alcohol effects onto his ongoing trial of topiramate for heavy drinkers, thus enabling the study of the effects of topiramate and drinking both in the lab (new data to be collected) and in the natural environment (through Ecological Momentary Assessment data that are already collected as part of his ongoing R01). Finally, as funding for his pending P60 application becomes clearer, he will begin pertinent pilot work on aspects of this project. PUBLIC HEALTH RELEVANCE: Advancing biopsychosocial approaches to alcohol treatment and mentoring has the potential to influence public health by reducing alcohol use in youth through improved early intervention and treatment. More and better mentored alcohol treatment scientists will facilitate the goal of reduced use in youth.

描述（由申请人提供）：这是高级研究和指导奖（K05）的新申请。候选人彼得·M·蒙蒂（Peter M.因此，蒙蒂博士建议从VA高级职业科学家奖过渡到K05。指导和指导计划。拟议中的一名受训者唐歌剧院（一名社会心理学家）最近是从牛津大学招募的，并且处于终身任职状态。另外两名拟议的教师Robert Miranda（临床心理学家）和Tara White（神经科学家）正在“研究”轨道上。尽管这三者都有出色的出版记录，但只有米兰达（Miranda）发表了酒精纸，并获得了NIAAA（K23和2 R21）的资金。歌剧和白人是NIDA资助的。 NIAAA的R01水平没有资金，尽管这三者都对成为酒精研究人员表示浓厚的兴趣。米兰达（Miranda）是最远的，尽管歌剧和怀特（White）都提交了酒精申请，作为候选人待定的P60中心赠款提案的一部分。第四个受训者玛吉·斯凯（Margie Skeer）（一名社会流行病学家）是与蒙蒂（Monti）合作的博士后候选人。她也有很强的出版记录。但是，尽管她表明对酒精感兴趣，但她只是出版了她的第一个酒精手稿，因为这是她来到布朗的原因。为所有申请人提供指导目标，涉及提供针对性的和一般指导和支持授予技巧，饮酒研究计划的发展以及更一般的专业发展问题，包括有关如何指导自己的受训者的反馈。重要的是，所有四个受训者都被纳入申请人的研究计划中，该计划正在朝着青少年酒精干预和酒精/艾滋病毒相互作用的研究方向发展。申请人打算在该领域以及神经科学和MRI模式中获得互补的专业知识 - 他的P60的所有主题。关于研究计划，申请人打算继续专注于广泛但专注于治疗机制，药物治疗，情境因素和个体差异的研究议程。他建议使用他的现有数据集研究治疗结果的调解人和主持人，并在他的简短干预工作中评估日常饮酒行为。此外，他还将在他正在进行的托吡酯试验中为重饮酒者添加基于实验室的酒精效应的研究，从而可以研究托吡酯和饮酒在实验室（将要收集的新数据）和自然环境中（通过已经作为他正在进行的R01的一部分收集的生态瞬时评估数据）的研究。最后，随着他未决的P60申请的资金变得更加清晰，他将开始在该项目方面进行相关的飞行员工作。 公共卫生相关性：推进饮酒和指导的生物心理社会方法有可能通过改善早期干预和治疗来减少青年的酒精饮酒来影响公共卫生。更多的指导性酒精治疗科学家将促进减少青年使用的目标。