Cardiopulmonary Mechanisms Affecting Cognition in COPD

影响慢性阻塞性肺病认知的心肺机制

• 批准号: 7786903
• 负责人: Karin F Hoth
• 金额: $ 14.84万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786903
• 关键词: Activities of Daily Living; Address; Affect; Aging; Attention; Attenuated; Behavioral Medicine; Blood Vessels; Brain; Cardiology; Cardiopulmonary; Cardiopulmonary Physiology; Cardiovascular Diseases; Cardiovascular system; Cerebral Ischemia; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Cognition; Cognitive deficits; Colorado; Data; Development; Development Plans; Disease; Doctor of Philosophy; Elderly; Environment; Etiology; Exercise; Forearm; Foundations; Functional disorder; Future; Goals; Gold; Hand; Health; Hypoxemia; Impaired cognition; Interdisciplinary Study; Intervention; Knowledge; Lead; Lung; Mediating; Medical; Medical History; Memory; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Modeling; Morbidity - disease rate; Neuraxis; Neuropsychological Tests; Obstruction; Outpatients; Participant; Patients; Peripheral; Phenotype; Physiological; Physiology; Play; Population; Prevalence; Pulmonary Emphysema; Pulmonology; Quality of life; Recruitment Activity; Relative (related person); Research; Research Activity; Research Personnel; Research Training; Rest; Risk Factors; Role; Severities; Severity of illness; Smoker; Staging; Stimulus; Structure; Techniques; Training; Training Activity; Training Support; United States; Universities; Vascular Diseases; abstracting; brachial artery; cardiopulmonary system; career development; cognitive function; daily functioning; disability; experience; follower of religion Jewish; improved; insight; mortality; prevent; programs; public health relevance; pulmonary function; response; skills

DESCRIPTION (provided by applicant): This application is a request for a Mentored Patient-Oriented Research Career Development Award to support the training and research activities necessary for Karin Hoth, Ph.D. to further develop into an independent investigator examining cardiopulmonary mechanisms that impact cognitive function. The applicant is a clinical neuropsychologist with research training and experience in aging and cardiovascular disease. The application extends Dr. Hoth's previous experience by integrating aspects of cardiovascular and pulmonary physiology as risk factors influencing cognitive decline in COPD. Training will be obtained through intensive didactic and hands-on research experiences available at National Jewish Health and the University of Colorado Denver. The training environment includes an interdisciplinary COPD clinical and research program with experts in pulmonary medicine, cardiology, and behavioral medicine. COPD is the fourth leading cause of combined morbidity, disability, and mortality in the United States, and is the only leading cause that is increasing in the elderly. Cognitive impairment is common in COPD, but the full range of underlying mechanisms that impact cognitive function in this population are not well understood. In the present study, we propose to examine the relationships among hypoxemia, diminished peripheral vascular reactivity, and cognitive impairment in patients with COPD. The career development plan is focused on three primary goals: 1) gaining knowledge related to cardiopulmonary physiology and the effects of physiological changes in COPD on the central nervous system; 2) improving knowledge of techniques for assessing cardiopulmonary physiology; and 3) developing skills related to conducting interdisciplinary research in the medical setting. The proposed project and training activities will lay the foundation for Dr. Hoth's long-term goal to develop an independent program of research to understand how alterations in the cardiopulmonary system as a whole impact the brain and cognitive functioning. PUBLIC HEALTH RELEVANCE: COPD is the fourth leading cause of morbidity, disability, and mortality in the United States. Cognitive impairment in COPD is common, and can negatively impact quality of life and daily functioning. Findings from the proposed study will have implications for understanding the etiology of cognitive deficits in COPD, and thus may identify factors to target for interventions to prevent or attenuate cognitive impairment. (End of Abstract)

描述（由申请人提供）：本申请是申请以患者为导向的研究职业发展奖，以支持 Karin Hoth 博士所需的培训和研究活动。进一步发展成为一名独立研究者，检查影响认知功能的心肺机制。申请人是一位临床神经心理学家，在衰老和心血管疾病方面接受过研究培训并拥有丰富的经验。该应用通过整合心血管和肺生理学方面作为影响慢性阻塞性肺病认知能力下降的危险因素，扩展了霍斯博士之前的经验。培训将通过国家犹太健康中心和科罗拉多大学丹佛分校提供的密集教学和实践研究经验来获得。培训环境包括由肺科、心脏病学和行为医学专家组成的跨学科慢性阻塞性肺病临床和研究项目。慢性阻塞性肺病是美国发病率、残疾率和死亡率的第四大原因，也是老年人中唯一增加的主要原因。认知障碍在慢性阻塞性肺病中很常见，但影响该人群认知功能的全部潜在机制尚不清楚。在本研究中，我们建议检查慢性阻塞性肺病患者低氧血症、外周血管反应性减弱和认知障碍之间的关系。职业发展计划侧重于三个主要目标：1）获得与心肺生理学以及慢性阻塞性肺病生理变化对中枢神经系统的影响相关的知识； 2）提高评估心肺生理学的技术知识； 3) 培养与在医疗环境中进行跨学科研究相关的技能。拟议的项目和培训活动将为霍斯博士的长期目标奠定基础，即开发一个独立的研究计划，以了解心肺系统的整体变化如何影响大脑和认知功能。 公共卫生相关性： COPD 是美国发病、残疾和死亡的第四大原因。慢性阻塞性肺病（COPD）中的认知障碍很常见，会对生活质量和日常功能产生负面影响。拟议研究的结果将对理解慢性阻塞性肺病认知缺陷的病因产生影响，从而可能确定预防或减轻认知障碍的干预措施的目标因素。 （摘要完）