Heart failure intervention and cognition in the elderly

老年人心力衰竭干预与认知

• 批准号: 6994081
• 负责人: Karin F Hoth
• 金额: $ 4.21万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6994081
• 关键词: behavioral /social science research tag; cerebrovascular disorders; clinical research; cognition disorders; echocardiography; electrocardiography; electronic pacemaker; functional ability; heart failure; heart function; heart prosthesis; hemodynamics; human old age (65+); human subject; human therapy evaluation; implantable defibrillators; interview; medical implant science; neural information processing; neuropsychological tests; outcomes research; postdoctoral investigator; postoperative state; questionnaires

DESCRIPTION (provided by applicant): Heart failure is one of the most significant causes of hospitalization, morbidity and mortality among elderly individuals in the United States. Research has demonstrated that patients with heart failure show cognitive impairment, which can impact functional abilities and quality of life. Medical interventions including implanted devices have led to improvements in symptom control and slowed progression of disease among patients with heart failure. Cardiac resynchronization therapy (CRT), a recently developed pacemaker based intervention, is associated with improvements on a range of cardiac functioning measures as well as enhanced health status and quality of life. However, no studies have examined cognitive functioning in this population, particularly in the context of change in cardiac functioning before and after CRT. In the present study, cardiac function and cognition will be examined among patients with heart failure before and after cardiac resynchronization therapy. This integration of cardiac and cognitive measures will help to elucidate the mechanisms by which cardiac disease is associated with cognitive decline, and will provide data on the effects of CRT on cognition.

描述（由申请人提供）：心力衰竭是美国老年人住院、发病和死亡的最重要原因之一。研究表明，心力衰竭患者表现出认知障碍，这会影响功能能力和生活质量。包括植入设备在内的医疗干预措施改善了心力衰竭患者的症状控制并减缓了疾病进展。心脏再同步治疗（CRT）是一种最近开发的基于起搏器的干预措施，与一系列心脏功能指标的改善以及健康状况和生活质量的提高有关。然而，尚无研究检查该人群的认知功能，特别是 CRT 前后心脏功能变化的情况。在本研究中，将对心力衰竭患者在心脏再同步治疗前后的心脏功能和认知进行检查。这种心脏和认知测量的整合将有助于阐明心脏病与认知能力下降的相关机制，并将提供有关 CRT 对认知影响的数据。