Validation of a Standardized Diagnostic Interview for Epilepsy

癫痫标准化诊断访谈的验证

• 批准号: 7921366
• 负责人: RUTH OTTMAN
• 金额: $ 7.97万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921366
• 关键词: Address; Age; Agreement; Area; Classification; Clinical; Collection; Communities; Computer Assisted; Consent; Data; Diagnosis; Diagnostic; Electroencephalography; Epidemiologic Studies; Epidemiology; Epilepsy; Etiology; Failure; Focal Seizure; Gold; Incidence; International; Interview; Interviewer; Investigation; Medical Records; Mental disorders; Minnesota; Neurologic Examination; Online Systems; Patients; Principal Investigator; Recording of previous events; Research; Residencies; Resources; Savings; Seizures; Symptoms; Syndrome; System; Telephone; Telephone Interviews; Time; Training; Validation; Validity and Reliability; base; clinical Diagnosis; computerized; genetic epidemiology; improved; instrument; nervous system disorder; neuroimaging; population based; public health relevance; tool; validation studies

DESCRIPTION (provided by principal investigator): Standardized tools for clinical diagnosis and classification are essential for consistency in epidemiologic studies, and are especially important for epilepsy because diagnosis and classification are largely based on patient history. Despite the importance of this problem, however, few tools have been developed for standardized collection of clinical information in the epilepsies. In the late 1980's we created a telephone-administered semistructured Epilepsy Diagnostic Interview for clinical classification. The original instrument had good inter-rater reliability and validity for distinguishing between generalized and partial seizures. However, since these early validation studies, we have made major revisions to the instrument to refine our ability to characterize seizure symptoms and thereby improve classification. In the current study we propose to validate this revised instrument and make it available to the research community in a web-based computerized telephone interview format. The data for validation will be from a population-based investigation using Rochester Epidemiology Project resources, the Genetic Epidemiology of Seizure Disorders in Rochester (GESDR) study. GESDR included all Rochester residents born in 1920 or later with incidence of unprovoked seizures from 1935-1994. For each of these subjects, two expert epileptologists carried out a comprehensive review of all medical record information from onset of seizures to last residency in the Rochester area (including seizure descriptions, EEG, neuroimaging, treatment history, etc.) and rendered a final epilepsy diagnosis and classification based on current ILAE criteria. Independently of the medical record review, we administered our current diagnostic interview to each surviving subject who consented, and the same epileptologists reviewed the interview data and rendered a diagnosis and classification based on interview data alone. In the validation study we will assess agreement between these two diagnoses, using the medical record diagnosis as the gold standard. PUBLIC HEALTH RELEVANCE: This project will evaluate the accuracy of clinical classification of epilepsy based on information collected in a standardized telephone interview. It will also produce a web-based computer-assisted telephone interview version of the validated interview. This should facilitate the conduct of epidemiologic research on the causes and consequences of epilepsy at a significant savings of time and money.

描述（由主要研究者提供）：临床诊断和分类的标准化工具对于流行病学研究的一致性至关重要，对于癫痫尤其重要，因为诊断和分类很大程度上基于患者病史。然而，尽管这个问题很重要，但用于标准化癫痫临床信息收集的工具却很少开发出来。 20 世纪 80 年代末，我们创建了用于临床分类的电话管理半结构化癫痫诊断访谈。原始工具在区分全身性癫痫发作和部分性癫痫发作方面具有良好的评估者间信度和效度。然而，自从这些早期验证研究以来，我们对仪器进行了重大修改，以提高我们表征癫痫症状的能力，从而改进分类。在当前的研究中，我们建议验证这一修订后的工具，并以基于网络的计算机化电话访谈的形式向研究界提供。用于验证的数据将来自使用罗切斯特流行病学项目资源进行的基于人群的调查，即罗切斯特癫痫症遗传流行病学 (GESDR) 研究。 GESDR 包括 1920 年或之后出生的所有罗切斯特居民，这些居民在 1935 年至 1994 年期间发生过无端癫痫发作。对于每一个受试者，两名癫痫专家对从癫痫发作到最后一次在罗切斯特地区居住的所有病历信息（包括癫痫描述、脑电图、神经影像、治疗史等）进行了全面审查，并得出了最终的癫痫结果根据现行 ILAE 标准进行诊断和分类。独立于病历审查，我们对每个同意的幸存受试者进行了当前的诊断访谈，同样的癫痫专家审查了访谈数据，并仅根据访谈数据做出了诊断和分类。在验证研究中，我们将使用病历诊断作为黄金标准来评估这两种诊断之间的一致性。 公共卫生相关性：该项目将根据标准化电话访谈中收集的信息评估癫痫临床分类的准确性。它还将生成经过验证的访谈的基于网络的计算机辅助电话访谈版本。这将有助于对癫痫的原因和后果进行流行病学研究，并节省大量时间和金钱。