"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"

“大规模衰老研究中的 MR 形态计量学和认知下降率”

• 批准号: 8292019
• 负责人: OWEN T. CARMICHAEL
• 金额: $ 10.36万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8292019
• 关键词: Accounting; Age; Aging; Area; Atrophic; Base of the Brain; Biological; Brain; Characteristics; Clinic; Cognition; Corpus Callosum; Dementia; Development Plans; Elderly; Epidemiology; Foundations; Hippocampus (Brain); Image; Impaired cognition; Measures; Medical Imaging; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Neuroanatomy; Pathologist; Pattern; Positioning Attribute; Psychologist; Psychology; Research; Research Personnel; Research Training; Scientist; Structure; Training; base; career; career development; caudate nucleus; cohort; experience; image processing; lateral ventricle; meetings; member; multidisciplinary; neuroimaging; population based; programs; research and development; skills; statistics; tool

DESCRIPTION (provided by applicant): his objective of this Mentored Research Scientist Development Award application is to obtain the training and research experience required for me to become a productive independent researcher investigating relationships between neuroimaging-based markers of brain structure and late-life cognitive decline. The application builds on my computational training in image processing to position me as an effective member of a multidisciplinary team that will be able to apply state-of-the-art neuroimaging methods to research questions related to cognitive decline while effectively interfacing with psychologists, pathologists, and other scientists with complementary expertise. The career development plan strengthens my foundation in image processing and supplements it with focused training in medical image acquisition, statistics and epidemiology, neuroanatomy, and psychology to make me a knowledgeable user of research tools from each of those areas. Training will be acquired through a structured program of formal coursework, focused meetings with area mentors, colloquia and seminars, and attendance of research meetings at a local and national level. The research plan develops the methodology required for large-scale study of relationships between imaging-based brain structure measures and cognitive decline, and applies the methodology to cohorts from population-based studies and an academic dementia clinic. The specific aims are to 1) investigate relationships between automated imaging-based measures of lateral ventricle structure and subsequent cognitive decline, 2) relate the structure of the lateral ventricles to the structure of periventricular structures, and 3) apply the automated image processing methodology developedfor the first two aims to large population-based cohorts with longitudinal imaging and cognition measures to cross-validate findings. The research and career development outlined in this application will leverage my unique computational skills into an effective career as an independent investigator able to contribute neuroimaging perspectives to our evolving understanding of the biological basis of late-life cognitive decline.

描述（由申请人提供）：他申请指导研究科学家发展奖的目的是获得我成为一名富有成效的独立研究人员所需的培训和研究经验，研究基于神经影像的大脑结构标记与晚年认知衰退之间的关系。该应用程序建立在我在图像处理方面的计算训练的基础上，使我成为多学科团队的有效成员，该团队将能够应用最先进的神经影像方法来研究与认知衰退相关的问题，同时有效地与心理学家、病理学家进行交流以及其他具有互补专业知识的科学家。职业发展计划加强了我在图像处理方面的基础，并通过医学图像采集、统计和流行病学、神经解剖学和心理学方面的集中培训对其进行补充，使我成为各个领域研究工具的知识渊博的用户。培训将通过正式课程、与地区导师的重点会议、座谈会和研讨会以及参加地方和国家层面的研究会议等结构化计划来获得。该研究计划开发了大规模研究基于成像的大脑结构测量与认知能力下降之间关系所需的方法，并将该方法应用于基于人群的研究和学术痴呆症诊所的队列。具体目标是 1) 研究基于自动成像的侧脑室结构测量与随后的认知能力下降之间的关系，2) 将侧脑室结构与脑室周围结构的结构联系起来，3) 应用为前两个目标是通过纵向成像和认知测量对大型人群进行交叉验证研究结果。本申请中概述的研究和职业发展将利用我独特的计算技能，作为一名独立研究者，将我的职业生涯转化为有效的职业，能够为我们对晚年认知衰退的生物学基础的不断发展的理解贡献神经影像学观点。

项目成果

[Tractography of the uncinate fasciculus and the posterior cingulate fasciculus in patients with mild cognitive impairment and Alzheimer disease].

轻度认知障碍和阿尔茨海默病患者钩束和后扣带束的纤维束成像[J].

• DOI: 10.1016/j.nrl.2013.02.002
• 发表时间: 2014
• 期刊: Neurologia (Barcelona, Spain)
• 作者: Larroza,A;Moratal,D;D'ocónAlcañiz,V;Arana,E;porlaAlzheimer'sDiseaseNeuroimagingInitiative
• 通讯作者: porlaAlzheimer'sDiseaseNeuroimagingInitiative

Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment.

• DOI: 10.1038/tp.2011.50
• 发表时间: 2011-11-15
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Hu X;Pickering EH;Hall SK;Naik S;Liu YC;Soares H;Katz E;Paciga SA;Liu W;Aisen PS;Bales KR;Samad TA;John SL
• 通讯作者: John SL

Risk classification in mild cognitive impairment patients for developing Alzheimer's disease.

• DOI: 10.3233/jad-2012-112117
• 发表时间: 2012
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Bin Zhou;E. Nakatani;S. Teramukai;Y. Nagai;M. Fukushima

How early can we predict Alzheimer's disease using computational anatomy?

• DOI: 10.1016/j.neurobiolaging.2013.06.015
• 发表时间: 2013-12-01
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Adaszewski, Stanislaw;Dukart, Juergen;Draganski, Bogdan
• 通讯作者: Draganski, Bogdan

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly.

RASGRF2 基因中与酒精摄入量减少相关的单核苷酸多态性预测老年人的皮质体积更大，但纵向心室扩张更快。

• DOI: 10.3389/fnagi.2013.00093
• 发表时间: 2013
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Roussotte,FlorenceF;Gutman,BorisA;Hibar,DerrekP;Jahanshad,Neda;Madsen,SarahK;JackJr,CliffordR;Weiner,MichaelW;Thompson,PaulM;Alzheimer’sDiseaseNeuroimagingInitiative(ADNI)
• 通讯作者: Alzheimer’sDiseaseNeuroimagingInitiative(ADNI)