Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)

通过运动降低非裔美国人阿尔茨海默病风险 - MCI 队列 (RAATE-MCI)

基本信息

批准号：
10393635
负责人：
OWEN T. CARMICHAEL
金额：
$ 93.46万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10393635
关键词：
Address Adult African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid Anti-Inflammatory Agents Biological Biological Assay Biological Markers Blood Blood Vessels Brain Brain-Derived Neurotrophic Factor Cardiovascular system Cerebrovascular Circulation Cerebrum Characteristics Chromosomes Chronic Clinical Cognitive Communities Control Groups Data Dementia Development Diagnosis Diet Education Effectiveness Elderly Episodic memory Ethnic Population Evaluation Exclusion Exercise Exposure to Functional Magnetic Resonance Imaging Genotype Hormones Impaired cognition Impairment Individual Insulin-Like Growth Factor I Intervention Ischemia Knowledge Length Leukocytes Longevity Magnetic Resonance Imaging Measurement Measures Mediating Memory Memory Loss Mental Depression National Institute on Alcohol Abuse and Alcoholism Nerve Degeneration Neurobiology Not Hispanic or Latino Other Genetics Outcome Participant Pathway interactions Patients Perfusion Phenotype Physical activity Physiological Population Positron-Emission Tomography Prevalence Public Health Randomized Randomized, Controlled Trials Recommendation Research Risk Risk Factors Risk Reduction Sample Size Sleep Structure Time Underserved Population White Matter Hyperintensity active control group brain tissue cardiorespiratory fitness cardiovascular risk factor caucasian American cerebrovascular clinical phenotype cognitive benefits cognitive enhancement cognitive function cohort comparison control depressive symptoms evidence base executive function exercise intervention experience fitness functional disability genetic risk factor gray matter health disparity improved insight mild cognitive impairment neuroimaging neuromechanism neuroprotection neuropsychiatry neurotrophic factor preservation prevent programs progression risk randomized, clinical trials recruit response sex symptomatology telomere trial design β-amyloid burden

项目摘要

Project Summary Alzheimer’s disease is steadily increasing in prevalence, with a devastating public health impact. The prevalence of Alzheimer’s Disease is higher in African Americans compared to white Americans, thereby constituting a health disparity. Individuals with mild cognitive impairment (MCI) are at increased risk for progressing to dementia, including AD dementia. Interventions that prevent Alzheimer’s disease or change the course of cognitive decline associated with Alzheimer’s disease are needed. Most older adults do not achieve recommended levels of physical activity, and this includes African Americans. Regular physical activity has proven to be a safe and effective means to enhance cognitive function in older adults with MCI. Therefore, our study is focused on physical activity promotion, a potent approach to modifying multiple neurobiological pathways implicated in Alzheimer’s Disease. We evaluate exercise benefits among elderly African Americans, who are understudied and in whom the natural course of neurodegeneration, exercise effects on neuroprotection and neurodegeneration, and resulting clinical phenotypes may differ. A large body of existing data suggests that exercise improves cardiovascular and cerebrovascular functioning, and thus has the potential to enhance perivascular clearance of amyloid and reduce chronic brain tissue ischemia, among other beneficial effects. At the same time, chronic exercise has been shown to increase central levels of neurotrophic factors, which in turn promote protection against Alzheimer’s Disease neurodegeneration pathways via a variety of mechanisms. While physical activity interventions have been shown to have positive effects on these factors and on resultant cognitive functioning in older adults, nearly all interventions have had a negligible representation of African Americans. Prior data suggests that African Americans enter their elderly years against a backdrop of different lifespan exposures to a variety of factors relevant to neuroprotection and neurodegeneration, including cardiovascular risk, exercise, diet, and education. In addition, prior data suggests that the key genetic risk factor for Alzheimer’s Disease (APOE) may have differing consequences for Alzheimer’s Disease risk among African Americans, and other genetic differences (i.e. leucocyte telomere length) have the potential to influence the brain benefits of physical activity in this community. We will utilize a randomized clinical trial to addresses these questions. Participants will be randomized into a physical activity promotion intervention or an active control group for 52 weeks. We will recruit a population with MCI. We will assess cognitive function, brain structure and function, circulating hormones, neurotrophic factors, objectively measured physical activity, cardiorespiratory fitness, sleep parameters, and telomere length. Our study will take the first step toward understanding whether the hypothesized benefits of exercise for the brain carry over to elderly African Americans with MCI.

项目概要阿尔茨海默病的患病率正在稳步上升，对公共健康产生了毁灭性的影响。与美国白人相比，非裔美国人阿尔茨海默病的患病率更高，因此构成健康差异的个体患有轻度认知障碍（MCI）的风险增加。进展为痴呆症，包括预防阿尔茨海默病或改变 AD 痴呆症的干预措施。大多数老年人无法实现与阿尔茨海默病相关的认知能力下降。建议的身体活动水平，其中包括非裔美国人。被证明是增强 MCI 老年人认知功能的安全有效的方法。研究重点是促进身体活动，这是一种改变多种神经生物学的有效方法我们评估了老年非裔美国人的运动益处，谁未被充分研究，以及神经退行性变的自然过程、运动对谁的影响神经保护和神经变性，以及由此产生的临床表型可能与现有的很大一部分不同。数据表明，运动可以改善心脑血管功能，从而具有具有增强血管周围淀粉样蛋白清除和减少慢性脑组织缺血等的潜力同时，长期锻炼已被证明可以提高中枢水平。神经营养因子，进而促进预防阿尔茨海默病神经退行性变虽然身体活动干预已被证明具有积极的作用，但通过多种机制。几乎所有干预措施都对这些因素以及由此产生的老年人认知功能产生影响先前的数据表明，非裔美国人进入老年人群体的比例微乎其微。在不同的寿命暴露于各种与神经保护和相关因素的背景下神经退行性变，包括心血管风险、运动、饮食和教育。表明阿尔茨海默病 (APOE) 的关键遗传风险因素可能对以下人群产生不同的后果非裔美国人的阿尔茨海默病风险以及其他遗传差异（即白细胞端粒）长度）有可能影响这个社区中身体活动对大脑的益处，我们将利用一个。为解决这些问题的随机临床试验将参与者随机分配到一项体育活动中。我们将招募 MCI 人群，进行为期 52 周的干预促进或积极对照组。客观评估认知功能、大脑结构和功能、循环激素、神经营养因子我们的研究将测量身体活动、心肺健康、睡眠参数和端粒长度。迈出第一步，了解运动对大脑的益处是否会持续下去患有 MCI 的老年非裔美国人。