Developmental Research Program

发展研究计划

• 批准号: 8330642
• 负责人: PETER NELSON
• 金额: $ 18.5万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8330642
• 关键词: Address; Area; Biological; British Columbia; Canada; Cancer Patient; Development; Diagnosis; Disease; Environment; Etiology; Fred Hutchinson Cancer Research Center; Funding; Funding Agency; General Hospitals; Genetic; Goals; Grant; Guidelines; Health Sciences; Institutes; Institution; Knowledge; Leadership; Malignant neoplasm of prostate; Morbidity - disease rate; Neoplasm Metastasis; Oregon; Pacific Northwest; Pilot Projects; Prevention; Prostate; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Systems Biology; Translational Research; United States National Institutes of Health; Universities; Washington; anticancer research; base; expectation; improved; innovation; mortality; programs; research study

The main purpose of the Developmental Research Program (DRP) of the Pacific Northwest (PNW) Prostate Cancer SPORE is to support innovative translational prostate cancer (PC) research pilot projects aimed at reducing the morbidity and mortality due to PC and at improving the survival and quality of life of PC patients. During the initial funding of the DRP, substantial progress has been made in the development and implementation of this unique and successful research program. During the first four years of the DRP, 46 pilot project proposals were submitted and 19 projects were funded (total of $798,100.00 direct funding). Ten publications and 7 grants have resulted to date from the DRP. For this continuation grant, the DRP program will continue to provide a mechanism to quickly respond to new translational research opportunities that may develop within the SPORE environments of participating institutions: Vancouver General Hospital (VGH) Prostate Centre in Vancouver, British Columbia, Canada; the University of Washington (UW), the Fred Hutchinson Cancer Research Center (FHCRC), and the Institute for Systems Biology (ISB) in Seattle, WA; and, Oregon Health Sciences University (OHSU) in Portland, OR. Support provided by the DRP will continue to allow innovative pilot projects to be initiated, with the expectation that the projects will mature sufficiently so that they can successfully compete for additional funding from sources either within or outside the SPORE grant. This program also attracts more senior investigators with diverse scientific expertise and new investigators into translational PC research. The specific aims for the DRP are: 1) Solicit innovative, translational prostate cancer research study proposals for pilot funding on an annual basis; 2) Convene a panel of experts to provide rigorous scientific review of pilot study proposals following NIH guidelines for selection of the most promising research projects; 3) Provide pilot study funding for 1-2 years for the most innovative investigator-initiated ideas for research in all areas of prostate cancer research (including etiology, prevention, diagnosis, biological mechanisms, genetics, and treatment) with a special emphasis on projects that address issues relevant to advancing knowledge of disease aggressiveness or metastasis; and, 4) Allow the SPORE leadership to target funds to specific areas that are especially likely to advance the translational research goals of the PNW prostate cancer SPORE.

太平洋西北（PNW）的发展研究计划（DRP）的主要目的 前列腺癌孢子是支持创新的转化前列腺癌（PC）研究试点项目 旨在降低由于PC引起的发病率和死亡率，并改善 PC患者。在DRP的最初资金中，开发已经取得了长足进展 并实施这个独特而成功的研究计划。在DRP的前四年中， 提交了46项试点项目建议，并资助了19个项目（总计798,100.00美元直接资金）。 从DRP造成了十份出版物和7条赠款。为此，DRP 计划将继续提供一种机制来快速响应新的翻译研究机会 可能在参与机构的孢子环境中发展：温哥华综合医院 （VGH）加拿大不列颠哥伦比亚省温哥华的前列腺中心；华盛顿大学（UW）， 弗雷德·哈钦森癌症研究中心（FHCRC）和西雅图的系统生物学研究所（ISB） wa;以及俄勒冈州波特兰的俄勒冈健康科学大学（OHSU）。 DRP提供的支持 继续允许启动创新的试点项目，并期望这些项目成熟 足够的足够，以便他们可以成功竞争从内部或外部来源的额外资金 孢子补助金。该计划还吸引了更多具有不同科学专业知识的高级调查员，并且 新研究人员转化PC研究。 DRP的具体目标是： 1）征求创新的，转化的前列腺癌研究研究提案 基础; 2）召集专家小组，提供对NIH之后的试点研究建议的严格科学审查 选择最有前途的研究项目的指南； 3）提供1 - 2年的试点研究资金 在前列腺癌研究的所有领域的研究（包括病因，预防，诊断，生物学 机制，遗传学和治疗）特别强调解决问题的项目 与促进疾病侵略性或转移的知识有关；和， 4）允许孢子领导层将资金瞄准特定领域，这些领域特别有可能促进该领域 PNW前列腺癌孢子的翻译研究目标。