Project 1: Endocrine Disruptors & Obesity Among Inner-City Children

项目一：内分泌干扰物

• 批准号: 8322716
• 负责人: Andrew G Rundle
• 金额: $ 19.43万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8322716
• 关键词: 5 year old; Adolescent; Adult; African American; Age; Area; Aromatic Polycyclic Hydrocarbons; Asthma; Birth; Blood Cells; Body Composition; Body Size; Body mass index; Cardiovascular Diseases; Child; Childhood; Communities; Data; Dependence; Development; Dominican; Endocrine Disruptors; Environmental Health; Epidemic; Epigenetic Process; Exposure to; Fatty acid glycerol esters; Food; Gender; Genes; Genetic; Grant; Growth; Height; Heritability; Human; Hunger; Intervention; Life; Link; Malignant Neoplasms; Measures; Mediating; Metabolic syndrome; Methylation; Minority; Mothers; New York City; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Population; Pregnancy; Public Health; Research; Risk; Sampling; Technology; Testing; Umbilical cord structure; United States; Urine; Weight; Weight Gain; air sampling; bisphenol A; cohort; early adolescence; early childhood; early life exposure; inner city; lipid biosynthesis; obesity in children; offspring; postnatal; prenatal; prenatal exposure; public health priorities

The specific aims are to evaluate whether prenatal and early-life exposures to the endocrine disruptors, bisphenol A (BPA) and polycyclic aromatic hydrocarbons (PAH), during pregnancy and early-childhood are associated with obesity and metabolic syndrome among children during early adolescence. The research will be conducted within the ongoing longitudinal birth cohort of African American and Dominican children from inner-city communities in New York City being conducted by the Columbia Center for Children's Environmental Health. BPA and PAH exposures are widespread among cohort mothers and children. Both compounds have been linked to obesity and metabolic syndrome in experimental and preliminary human studies. The research is timely; childhood obesity is increasing rapidly within the United States, with rates highest among minority populations. By age 5 years, 43% of our cohort children exceed the 85% of weight for age. The epidemic is likely to have significant public health implications, particularly among minority populations, as obesity is linked to risk of type 2 diabetes and cardiovascular disease. We propose to follow the children in the cohort to age 8-10 years and will assess height, weight, and body composition at ages 5, 7 and 8-10 years and metabolic syndrome components at ages 8-10. Exposure dosimeters are PAH concentrations in maternal prenatal personal air samples and PAH and BPA metaboltites concentrations in urine samples collected and stored from the mother during pregnancy and from the child at ages 3,5, and 7 years. We hypothesize that prenatal exposure to PAH and BPA (1) will be associated with higher weight gain trajectories from age 5 to 8-10, and at age 8-10 years with BMI z-score, fat mass and metabolic syndrome components and (2) will alter the methylation status of key genes involved in adipogenesis and hunger control measured in umbilical cord while blood cells, which will mediate the association between postnatal exposures to the endocrine disruptors and childhood obesity outcomes. The research will provide important data on whether prenatal/early-life expsoures to endocrine disruptors predicts childhood obesity/metabolic syndrome and will test hypotheses regarding underlying epigenentic mechansisms.

具体目的是评估产前和早期对内分泌干扰物的暴露， 双足A（BPA）和多环芳烃（PAH），怀孕和早期期间 青春期初期与儿童的肥胖和代谢综合征有关。研究将 在正在进行的非裔美国人和多米尼加儿童的纵向出生队列中进行 哥伦比亚儿童中心进行纽约市的内城社区 环境健康。 BPA和PAH暴露在同胞母亲和儿童中广泛。两个都 化合物与实验和初步人类的肥胖和代谢综合征有关 研究。研究是及时的。在美国，儿童肥胖症正在迅速增加，利率 在少数民族中最高。到5岁时，我们的队列儿童中有43％超过了体重的85％ 年龄。这种流行病可能具有重大的公共卫生影响，尤其是在少数民族中 人群，因为肥胖与2型糖尿病和心血管疾病的风险有关。我们建议遵循 队列中的儿童至8-10岁，将评估5岁的身高，体重和身体成分 7-10岁的7和8-10岁，年龄8-10岁。暴露剂量计为PAH 母体产前个人空气样品的浓度以及PAH和BPA元托硫烷的浓度 尿液样本在怀孕期间从母亲那里收集并存储在3,5岁的儿童中，7个 年。我们假设产前暴露于PAH和BPA（1）将与更高的体重有关 从5至8-10岁到8-10岁，在8-10岁时获得BMI Z分数，脂肪质量和代谢的轨迹 综合征成分和（2）将改变参与成生成和的关键基因的甲基化状态 在脐带中测量的饥饿控制，而血细胞将介导 产后暴露于内分泌破坏者和儿童肥胖结果。研究将提供 关于内分泌干扰物的产前/早期生活的重要数据是否预测童年 肥胖/代谢综合征，并将检验有关潜在表观遗传机械主义的假设。