Neural, dyadic, and cultural influences on risk for anxiety in young Latinx children

神经、二元和文化对拉丁裔儿童焦虑风险的影响

基本信息

批准号：
10723898
负责人：
Laura Quinones-Camacho
金额：
$ 17.96万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723898
关键词：
4 year old 5 year old Adolescence Adolescent Adult Age Anxiety Anxiety Disorders Area Biological Biological Markers Caregivers Child Childhood Clinical Communities Coupling Data Data Analyses Data Collection Development Discrimination Disease Distress Electroencephalography Emotional Emotions Environment Environmental Risk Factor Ethnic Population Event Exclusion Family Fright Functional disorder Goals Income Individual Intervention Knowledge Latinx Life Link Literature Longevity Longitudinal Studies Maps Measures Mediating Mental disorders Mentored Research Scientist Development Award Mentors Methodology National Institute of Mental Health Nursery Schools Parents Pattern Play Population Process Psychopathology Regulation Research Rest Risk Risk Factors Role Sampling Shapes Socialization Symptoms System Techniques Texas Time Training Visit Well in self Work Youth anxiety symptoms anxious anxious behavior associated symptom childhood anxiety computerized data processing emotion regulation experience high risk multidisciplinary multimodality neural neural correlate programs protective factors resilience satisfaction skills social culture stressor

项目摘要

PROJECT SUMMARY Anxiety symptoms are one of the most prevalent and earliest forms of psychopathology in childhood and have been linked with lasting effects on socioemotional wellbeing, reduce life satisfaction, and increase chance of more severe psychopathology developing into adolescence and adulthood. Latinx children and adolescents experience alarmingly high rates of anxiety and related internalizing disorders compared to other ethnic groups, with some studies finding rates as high as 40%. Yet, we know little about risk and protective factors for the emergence of symptoms in these children. Consistent with NIMH’s Strategic Objective 2 “to examine mental illness trajectories across the lifespan” this K01 proposal will investigate early predictors of emerging anxious behaviors, including neural biomarkers (Aim 1) and caregiver-child factors (Aim 2), while also considering how broader cultural processes may influence risk trajectories for Latinx youth (Aim 3) from the toddlerhood to preschool period. Knowledge from the proposed project could have a substantial impact on our ability to identify which Latinx children are most likely to start trajectories towards anxiety early in life and could help generate culturally-tailored interventions to modify developmental trajectories away from increased symptoms in these children. This proposal leverages the opportunity to add measures to an ongoing 5-year longitudinal study with children from a primarily Latinx area of Central Texas. This K01 proposal will add an in- lab visit with neural and caregiver-child observational measures. The proposal will use EEG-based resting- state measures (i.e., alpha asymmetry, beta-delta coupling) to assess general emotional processing and regulatory tendencies (Aim 1), and observational measures of caregiver-child interactions to assess caregiver- child emotion socialization (Aim 2). Additionally, the proposed K01 project will leverage caregiver and child anxiety symptom and cultural socialization data (Aim 3) already being collected as part of the larger study. Through this Mentored Research Scientist Development Award (K01) the applicant will get needed training and expertise on 1) EEG biomarkers in young children; 2) anxiety from a developmental psychopathology perspective; 3) dyadic and longitudinal data analysis; and 4) cultural approaches. A rich training environment with a multidisciplinary team of mentors and consultants in each of these areas has been assembled to meet these goals. Findings from this study will offer the opportunity to map anxious trajectories as well as risk and protective factors at a younger age than typically studied in Latinx youth development, and when dysregulation patterns start to become noticeable but are still highly malleable. The proposed research and training plan will enable the candidate to succeed in their long-term goal of launching a fully independent and unique research program using multi-modal approaches to study biological and dyadic emotion-related processes, as well as resilience mechanisms that may shape anxiety trajectories in young, particularly Latinx, children.

项目概要焦虑症状是儿童时期最普遍和最早的精神病理学形式之一，并且与社会情感健康的持久影响、降低生活满意度以及增加患病机会有关拉丁裔儿童和青少年发展中的精神病理学更为严重。与其他种族相比，焦虑和相关内化障碍的发生率高得惊人一些研究发现这一比例高达 40%，然而，我们对风险和保护因素知之甚少。这些儿童出现的症状符合 NIMH 的战略目标 2“进行检查”。整个生命周期的精神疾病轨迹”这项 K01 提案将调查新出现的精神疾病的早期预测因素焦虑行为，包括神经生物标志物（目标 1）和照顾者儿童因素（目标 2），同时还考虑更广泛的文化进程如何影响拉丁裔青年的风险轨迹（目标 3）从幼儿期到学前班期间获得的知识可能会对我们产生重大影响。能够识别哪些拉丁裔儿童最有可能在生命早期就开始走向焦虑，并且可以帮助制定适合文化的干预措施，以改变发展轨迹，避免增加该提案利用这个机会在持续的 5 年中增加措施。这项 K01 提案将针对来自德克萨斯州中部主要拉丁裔地区的儿童进行纵向研究。该提案将使用基于脑电图的静息观察措施进行实验室访问。状态测量（即 alpha 不对称性、beta-delta 耦合）来评估一般情绪处理和监管倾向（目标 1），以及照顾者与儿童互动的观察措施，以评估照顾者- 此外，拟议的 K01 项目将利用照顾者和儿童。作为更大规模研究的一部分，已经收集了焦虑症状和文化社会化数据（目标 3）。通过该导师研究科学家发展奖（K01），申请人将获得所需的培训和 1) 幼儿脑电图生物标志物的专业知识；2) 发展性精神病理学引起的焦虑视角；3）双向和纵向数据分析；4）丰富的培训环境。每个领域都聚集了一个由导师和顾问组成的多学科团队来满足这项研究的这些目标将为绘制焦虑轨迹以及风险和风险提供机会。比拉丁裔青少年发展中通常研究的年龄更小的保护因素，以及当调节失调时模式开始变得明显，但仍具有很强的可塑性。使候选人能够成功实现开展完全独立和独特研究的长期目标使用多模式方法来研究生物和二元情感相关过程的计划，以及可能塑造年轻儿童（尤其是拉丁裔儿童）焦虑轨迹的弹性机制。