Psychosocial Factors in Reproductive Aging

生殖衰老的心理社会因素

• 批准号: 8313969
• 负责人: Maria E. Bleil
• 金额: $ 11.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8313969
• 关键词: Accounting; Address; Adolescence; Adolescent; Adrenal Glands; Adult; Affect; African; African American; Age; Age at Menarche; Age-Years; Aging; Aging-Related Process; American; Antral; Anxiety; Area; Attenuated; Behavioral; Biological; Body mass index; California; Caucasians; Caucasoid Race; Central American; Characteristics; Childhood; Chinese American; Chinese People; Chronic Disease; Clinical; Coronary heart disease; DSM-IV; Depressed mood; Development; Disease; Enrollment; Environmental Exposure; Epidemiology; Estradiol; Ethnic Origin; Ethnic group; Exhibits; Female; Filipino; Filipino American; Funding; Goals; Health; Health Status; Home environment; Hydrocortisone; Hypothalamic structure; Individual; Interdisciplinary Study; Intervention; Interview; Investigation; Knowledge; Latino; Life Cycle Stages; Light; Link; Longevity; Major Depressive Disorder; Measures; Mediating; Mediator of activation protein; Menopausal Status; Menopause; Menstruation; Mental Depression; Methods; Mexican; Modeling; Morbidity - disease rate; Mothers; National Institute of Child Health and Human Development; Nature; Neuroendocrinology; Osteoporosis; Ovarian; Ovary; Parents; Participant; Patient Self-Report; Perimenopause; Persons; Pituitary Gland; Protocols documentation; Psychiatric Diagnosis; Psychosocial Factor; Puberty; Public Health; Questionnaires; Recording of previous events; Recruitment Activity; Regulation; Reproductive Endocrinology; Research Design; Research Personnel; Risk; Risk Factors; Salivary; Sampling; Sampling Studies; San Francisco; Severities; Smoking; Social status; Socioeconomic Status; Staging; Structure; Symptoms; System; Testing; Time; Training; Transvaginal Ultrasound; United States National Institutes of Health; Universities; Uterus; Woman; Women' s Health; Work; base; biological adaptation to stress; center for epidemiological studies depression scale; cigarette smoking; depressive symptoms; early onset; experience; female reproductive system; gonad function; hypothalamic pituitary gonadal axis; hypothalamic-pituitary-adrenal axis; indexing; interest; low socioeconomic status; meetings; modifiable risk; mortality; parity; prospective; psychosocial; reproductive; reproductive development; research study; stem

DESCRIPTION (provided by applicant): This CDA will provide the candidate the opportunity to enact a comprehensive training plan that will enable her to become an independent, interdisciplinary research investigator with specific expertise in the area of female reproductive aging, a topic of enormous public health concern in light of the rapidly increasing number of American women entering menopause each year. Menopause marks a time of significant change not only in a woman's reproductive status but also in her health more generally. Women entering menopause are at increased risk for several chronic diseases which account for a significant morbidity and mortality burden. In this regard, elucidating factors that explain variance in the timing of menopause onset is of critical importance. Emerging evidence shows that psychosocial factors, including lower socioeconomic status (SES) and depression history, are related prospectively to earlier onset menopause. The relation of these factors to the reproductive aging process underlying menopause onset, however, is not known. Here, psychosocial factors will be examined in relation to ovarian aging, indexed by antral follicle count (AFC), in a sample of healthy, reproductive age women (N = 850). Specifically, the candidate will utilize her CDA training experiences in the areas of the epidemiology of women's health, reproductive endocrinology, and psycho-neuroendocrinology to conduct 2 studies that stem from an ongoing funded research study at the University of California San Francisco. Study 1 aims (1) to examine SES over the life course (periods of childhood, adolescence, adulthood) in relation to ovarian aging, (2) to examine the potential behavioral/psychosocial mediators of SES effects on ovarian aging, and (3) to determine whether SES effects on ovarian aging differ across women of various ethnic backgrounds. Study 2 aims to determine (1) whether women with Major Depressive Disorder (N = 50) exhibit accelerated ovarian aging compared to never-depressed women (N = 50) and (2) whether disruptions in the regulation of the female reproductive system by the hypothalamic-pituitary-gonadal (HPG) axis and its interaction with the hypothalamic-pituitary-adrenal (HPA) axis may explain this difference. Life course SES and psychiatric diagnoses will be assessed by structured interviews, psychosocial factors by standardized self-report questionnaires, AFC by transvaginal ultrasound, and HPG and HPA function by salivary measures of estradiol and cortisol, respectively. Results will elucidate possible modifiable risk factors for accelerated ovarian aging underlying earlier onset menopause.

描述（由申请人提供）：该CDA将为候选人提供制定全面的培训计划的机会，该计划将使她成为一名独立的，跨学科的研究调查员，在女性生殖衰老领域具有特定的专业知识，这是一个众所周知的公共卫生关注的话题，这是鉴于每年进入Menopause的美国女性的迅速增加。更年期标志着不仅在女性的生殖状况上，而且更广泛地改变了她的健康状况。进入更年期的妇女患几种慢性疾病的风险增加，这些慢性疾病造成了巨大的发病率和死亡率负担。在这方面，阐明了解释更年期开始时间方面的差异的因素至关重要。新兴的证据表明，包括较低的社会经济地位（SES）和抑郁史在内的社会心理因素前景与早期发作相关。然而，这些因素与更年期发作的生殖衰老过程的关系尚不清楚。在这里，将在健康，生殖年龄妇女的样本中检查与卵巢老化相关的心理因素（n = 850）。具体而言，候选人将在妇女健康，生殖内分泌学和心理神经内分泌学的流行病学领域中利用她的CDA培训经验进行2项研究，源于加利福尼亚大学旧金山大学正在进行的资助研究。研究1的目的（1）旨在检查与卵巢衰老有关的生命过程（儿童期，青春期，成年期）的SES，（2）检查SES对卵巢衰老的影响的潜在行为/社会心理介体对卵巢衰老的影响，以及（3）确定SES对各个民族背景的卵巢衰减妇女的影响是否对卵巢衰老的影响是否影响。研究2旨在确定与永不抑郁的妇女（n = 50）相比，患有重度抑郁症（n = 50）的女性是否表现出加速的卵巢衰老（n = 50）和（2）（2）是否通过下丘脑 - 坐骨 - 彼得 - 彼得 - 婚姻（HPG）轴（HPG）轴的互动和与下层的次数相互作用（Hypotiitai-pitatarary-pitay-pita）（Hypitary-pitatary-apedarary-appitary-hypatary-a）。生命课程SES和精神病诊断将通过结构化访谈，标准化自我报告问卷，经阴道超声检查的AFC以及HPG和HPA功能分别通过雌二醇和皮质醇的唾液量来评估。结果将阐明可能改变的危险因素，以加速早期发作的卵巢衰老。