Early Adversity, Childhood Educational Experiences, and Adulthood Physical Health

早期逆境、童年教育经历和成年身体健康

• 批准号: 10385680
• 负责人: Maria E. Bleil
• 金额: $ 43.52万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10385680
• 关键词: Academic achievement; Academic skills; Achievement; Address; Adolescent; Adult; Affect; Age; Behavioral; Birth; Blood; Body mass index; Cardiovascular Diseases; Child; Child Care; Childhood; Data Collection; Data Set; Development; Education; Educational Status; Environment; Ethnic Origin; Evaluation; Event; Family; Fathers; Female; Funding; Gender; Health; Health behavior; Home environment; Infant; Inflammation; Instruction; Intelligence; Intervention; Life; Life Cycle Stages; Life Style; Link; Literature; Measures; Mediating; Mediator of activation protein; Medical History; Metabolic; Modeling; Mothers; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; Nature; Onset of illness; Outcome; Participant; Pathway interactions; Physical Examination; Physical activity; Positioning Attribute; Prevention; Prospective Studies; Questionnaires; Race; Reporting; Research Support; Risk; Risk Marker; Sampling; Sampling Studies; Schools; Sum; Temperament; Testing; Time; United States National Institutes of Health; Variant; Visit; base; cardiometabolism; cardiovascular health; childhood adversity; cohort; design; disorder risk; early life adversity; experience; follow-up; health assessment; infancy; lifestyle factors; male; maltreatment; mortality; physical conditioning; prospective; sex; teacher

PROJECT SUMMARY: Although the association between educational attainment and physical health outcomes—including leading causes of mortality like cardiovascular disease—is well known to be large in magnitude, enduring over the life course, and invariant across sex, race, and ethnicity, there are few existing studies that are capable of prospectively disambiguating aspects of early education that are most predictive of physical health in adulthood and thus most productively targeted in intervention and prevention efforts. Likewise, few studies of the school context are also well positioned to incorporate in the same sample correlated aspects of risk in children's early home environments that might initiate a developmental cascade resulting in poorer physical health outcomes in adulthood via childhood educational experiences. To address these limitations, the current application is designed to leverage the landmark NICHD Study of Early Child Care and Youth Development (SECCYD; 1991- 2006), a large-scale, prospective study of children thus far followed prospectively from birth, to evaluate a life course model whereby early life adversity is hypothesized to confer risk for intermediate health outcomes relevant to health risk partially through correlated variation in both a) academic achievement and attainment and b) educational experiences during childhood (e.g., the quality of educational experiences, both interpersonal and instructional in nature). Building on an NHLBI-sponsored follow-up of the female sub-sample of the SECCYD (pending R01HL130103, PI: Bleil, to begin 7/1/16), funding for the current application will enable identical assessments in the male participants including relevant parameters of health/disease risk. This effort will produce a high powered study of 750 total SECCYD participants (~50% male; ages 25-30 over study period), assuming 80% return of 940 participants. The follow-up visit will involve assessments in domains of cardio-metabolic and inflammation known to predict long-term risk for disease derived from a physical examination, blood draw, and comprehensive medical history/health behavior evaluation. These new measures generated from the current study will be examined in relation to existing, state-of-the-art assessments of early life environments and educational achievement/experiences acquired as a part of the original SECCYD data collection on both genders. Early life adversity will be characterized using measures of childhood SES, infant-mother attachment, maternal sensitivity, father absence, negative life events, and maltreatment. Academic achievement will be assessed using teacher-reported and objective assessments of academic skills whereas educational experiences will be studied using classroom observations along with questionnaire assessments of the quality of teacher-child relationships. In sum, the proposed study reflects a unique, time-sensitive opportunity to examine longitudinally the extent to which academic achievement and/or the quality of childhood educational experiences uniquely predict health risk in adulthood, as well as to explore childhood variables that moderate, and adult behavioral/lifestyle variables that mediate these prospective associations.

项目摘要： 尽管教育成就与身体健康成果之间的联系 - 包括领导 诸如心血管疾病之类的死亡率的原因 - 众所周知，大小很大，在生活中持续 在性别，种族和种族中的课程和不变，现有的研究很少 前瞻性地消除早期教育的歧义方面，这些方面最能预测成年的身体健康 因此，最有效地针对干预和预防工作。同样，学校的研究很少 上下文也可以很好地纳入儿童早期风险相关的风险相关方面 可能引发发育级联的家庭环境，导致身体健康状况较差 通过儿童教育经验成年。为了解决这些限制，当前的应用程序是 旨在利用具有里程碑意义的NICHD对幼儿保育和青年发展的研究（Seccyd; 1991- 2006年），一项大规模的，前瞻性的研究，迄今为止，从出生开始适当地跟随儿童，以评估生活 课程模型，假设早期生命冒险是中间健康结果的会议风险 与健康风险相关，部分通过相关的差异a）学术成就和成就以及 b）童年时期的教育经验（例如，教育经验的质量，人际关系和 本质上的教学）。在NHLBI赞助的SECCYD女性子样本的随访中建立 （在R01HL130103，PI：BLEIL，16年7月1日开始），当前申请的资金将启用相同 男性参与者的评估，包括健康/疾病风险的相关参数。这种努力将产生 对750个SECCYD参与者的高功率研究（男性约50％；研究期25-30岁），假设 940名参与者的80％回报。后续访问将涉及心脏代谢领域的评估和 已知的炎症可以预测从体格检查，抽血和 全面的病史/健康行为评估。这些新的措施从当前产生 研究将与对早期生活环境的现有，最新评估有关的研究和 作为原始的SECCYD数据收集的一部分，获得的教育成就/经验 性别。早期的广告将使用儿童SES，婴儿依恋的度量来表征 孕产妇的敏感性，父亲的吸收，负面的生活事件和虐待。学术成就将是 使用教师报告和客观评估学术技能评估，而教育 经验将使用课堂观察以及问卷调查质量进行研究 教师关系。总而言之，拟议的研究反映了一个独特的时间敏感的机会来检查 纵向学术成就和/或儿童教育经验的质量在多大程度上 独特地预测成年中的健康风险，以及探索现代化和成人的童年变量 介导这些前瞻性关联的行为/生活方式变量。