Epidemiology of testicular cancer in the Utah population

犹他州人群睾丸癌的流行病学

• 批准号: 8260835
• 负责人: MIA HASHIBE
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260835
• 关键词: 20 year old; Affect; African American; Age; Asians; Birth Certificates; Birth Order; Cancer Patient; Cardiovascular Diseases; Case-Control Studies; Cessation of life; Characteristics; Colorectal Cancer; Conflict (Psychology); Contralateral; Cryptorchidism; Data; Data Sources; Databases; Death Records; Denmark; Descriptive Epidemiology; Disease; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Ethnic Origin; Europe; European; Exposure to; Family; Family history of; Follow-Up Studies; General Population; Genes; Genetic; Health Planning; Hemorrhage; Histology; Impaired Renal Function; Incidence; Licensing; Link; Low Birth Weight Infant; Lung diseases; Malignant Neoplasms; Malignant neoplasm of prostate; Malignant neoplasm of testis; Medical Records; Mental Depression; Northern Europe; Norway; Odds Ratio; Outcome; Paresthesia; Patient Self-Report; Perinatal; Population; Population Database; Pregnancy; Premature Birth; Prevention; Primary Neoplasm; Proxy; Public Health; Race; Recording of previous events; Records; Relative (related person); Research Design; Resources; Risk; Risk Factors; Rural; Scandinavia; Second Degree Relative; Subgroup; Time; United States; Utah; abstracting; aged; agricultural activity; anticancer research; autism spectrum disorder; base; cancer risk; cohort; design; drinking water; epidemiology study; follow-up; high risk; malignant breast neoplasm; melanoma; men; neoplasm registry; neurotoxicity; outcome forecast; pesticide exposure; population based; postnatal; prenatal; public health relevance; residence; trend

DESCRIPTION (provided by applicant): Abstract The incidence rate for testicular cancer in Utah is the highest of all the cancer registries in the United States (8.3 per 100,000 in 2007). On a worldwide level, approximately 52,549 cases and 9,906 deaths occur due to testicular cancer each year. It is one of the few cancers with increasing incidence over the last few decades in the US and Europe. In Utah, the age-adjusted incidence rates for men aged 15-49 years increased from 6.4 in 1973 to 13.8 in 2007. The five year survival among testicular cancer patients in the US was 96.0% for men > 20 years old (1988-2001). The well-established testicular cancer risk factors include age, contralateral testicular cancer, cryptorchidism, race/ethnicity and family history of testicular cancer. Other factors that have been examined but have led to conflicting results across studies include lower birth order, higher maternalage, short gestational duration, and low birth weight. Thus far, an epidemiologic study on testicular cancer in Utah has never been conducted. The Utah Population Database (UPDB) is an existing data source that provides an excellent opportunity to examine testicular cancer trends, risk factors and prognosis in Utah. It has been used in various gene identifying and familial clustering studies for breast cancer, colorectal cancer, melanoma and prostate cancer, but this will be the first application of using this database for studying testicular cancer risk factors. Additionally, the UPDB has been used to study prenatal factors from birth certificate records as possible risk factors for outcomes such as preterm births and autism spectrum disorders, but prenatal factors have not been studied for any cancers thus far in the UPDB. The UPDB has over 14.5 million records with linkage across cancer registry data, birth certificate records, death records, driver's license records, and medical records. We also have access to geocoded data on proximity to specific agricultural activities (as a proxy for pesticide exposure) and exposure to contaminants in drinking water in Utah, which will be linked to the UPDB records. We propose to conduct the following studies within the UPDB: 1) a descriptive epidemiology of testicular cancers, 2) a population-based case-control study, and 3) a follow up study of testicular cancer patients. We expect to include approximately 1,826 testicular cancer patients (1973-2007) for the descriptive epidemiology and follow up studies. For the case-control study, we will include 1,826 testicular cancer patients and 5,478 controls (3 controls per case). Our specific aims are in parallel to the study designs: 1) to investigate the testicular cancer trends for the Utah population, 2) to examine prenatal and perinatal factors, history of previous disease, family history of cancer, and rural residence as possible risk factors for testicular cancer, and 3) to study survival, and incidence of second primary tumors, cardiovascular disease, depression and other diseases among testicular cancer patients in Utah. This study will be the first epidemiologic study of testicular cancer in Utah. We will take advantage of a unique existing data resource to contribute to a better understanding of testicular cancer in Utah. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Our project on testicular cancer in Utah is important for public health because it will contribute to a better understanding of the trends over time and the risk factors are important for testicular cancer in this high risk population. We will also study the prognosis of testicular cancer patients and examine what factors affect prognosis. Our results will be relevant for public health planning of prevention efforts against testicular cancer in Utah.

描述（由申请人提供）： 摘要 犹他州睾丸癌的发病率是美国所有癌症登记处中最高的（2007 年为每 100,000 人 8.3 例）。在全世界范围内，每年约有 52,549 例睾丸癌病例和 9,906 例死亡。它是过去几十年来美国和欧洲发病率不断上升的少数癌症之一。在犹他州，15-49 岁男性的年龄调整发病率从 1973 年的 6.4 上升到 2007 年的 13.8。美国 20 岁以上男性睾丸癌患者的五年生存率为 96.0%（1988-2001 年） ）。公认的睾丸癌危险因素包括年龄、对侧睾丸癌、隐睾、种族/民族和睾丸癌家族史。其他已被研究但导致研究结果相互矛盾的因素包括出生顺序较低、孕产期较高、妊娠持续时间短和出生体重低。迄今为止，犹他州尚未进行过睾丸癌的流行病学研究。犹他州人口数据库 (UPDB) 是一个现有的数据源，为检查犹他州睾丸癌趋势、危险因素和预后提供了绝佳的机会。它已被用于乳腺癌、结直肠癌、黑色素瘤和前列腺癌的各种基因识别和家族聚类研究，但这将是使用该数据库研究睾丸癌危险因素的首次应用。此外，UPDB 还被用来研究出生证明记录中的产前因素，将其作为早产和自闭症谱系障碍等结局的可能风险因素，但 UPDB 迄今为止尚未对任何癌症进行产前因素研究。 UPDB 拥有超过 1450 万条记录，这些记录与癌症登记数据、出生证明记录、死亡记录、驾驶执照记录和医疗记录之间存在关联。我们还可以获得有关犹他州特定农业活动邻近程度（作为农药暴露程度的代表）和饮用水污染物暴露程度的地理编码数据，这些数据将与 UPDB 记录相关联。我们建议在 UPDB 内进行以下研究：1）睾丸癌的描述性流行病学，2）基于人群的病例对照研究，3）睾丸癌患者的随访研究。我们预计将纳入大约 1,826 名睾丸癌患者（1973-2007 年）进行描述性流行病学和后续研究。对于病例对照研究，我们将纳入 1,826 名睾丸癌患者和 5,478 名对照者（每个病例 3 名对照者）。我们的具体目标与研究设计并行：1) 调查犹他州人口的睾丸癌趋势，2) 检查产前和围产期因素、既往病史、癌症家族史和农村居住作为可能的危险因素睾丸癌，3) 研究犹他州睾丸癌患者的生存率以及第二原发肿瘤、心血管疾病、抑郁症和其他疾病的发病率。这项研究将是犹他州第一项睾丸癌流行病学研究。我们将利用独特的现有数据资源来帮助更好地了解犹他州的睾丸癌。 公共卫生相关性：项目叙述 我们在犹他州的睾丸癌项目对于公共卫生很重要，因为它将有助于更好地了解随着时间的推移的趋势，并且风险因素对于这一高危人群的睾丸癌很重要。我们还将研究睾丸癌患者的预后，并探讨哪些因素影响预后。我们的结果将与犹他州睾丸癌预防工作的公共卫生规划相关。

项目成果

Mental health disorders among ovarian cancer survivors in a population-based cohort.

• DOI: 10.1002/cam4.4976
• 发表时间: 2023-01
• 期刊: CANCER MEDICINE
• 影响因子: 4
• 作者: Hu, Siqi;Baraghoshi, David;Chang, Chun-Pin;Rowe, Kerry;Snyder, John;Deshmukh, Vikrant;Newman, Michael;Fraser, Alison;Smith, Ken;Peoples, Anita R.;Gaffney, David;Hashibe, Mia
• 通讯作者: Hashibe, Mia