A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
基本信息
- 批准号:8245200
- 负责人:
- 金额:$ 38.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAgeAnimal ModelApoptosisAreaAtlasesBehaviorBioinformaticsBirdsBrainBrain MappingBrain regionCell Cycle RegulationCell NucleusCell divisionChickensComparative Genomic AnalysisComplexConsultationsDataDatabasesDevelopmentDiseaseEndogenous FactorsEnvironmental Risk FactorEnzymesExpressed Sequence TagsFundingFutureGene ExpressionGene Expression ProfileGene Expression RegulationGene FamilyGene StructureGene Transfer TechniquesGenesGeneticGenomeGenomicsGoalsGonadal Steroid HormonesGrantGrowthGrowth FactorHealthHormonalHormonesHumanImpairmentIndividualIon ChannelKnock-outKnowledgeLanguage DevelopmentLearningLibrariesLinkLiteratureMammalsMapsModelingMolecularMolecular GeneticsMolecular ProfilingMusNational Human Genome Research InstituteNational Institute of Neurological Disorders and StrokeNerve Growth Factor ReceptorsNeurobiologyNeuromodulatorNeuronsNeurosecretory SystemsNeurotransmitter ReceptorNeurotransmittersNuclearNutritionalOnline SystemsOrganismPhysiological ProcessesPlayProductionPropertyReceptor CellReceptor GeneRegulationReproductive BehaviorResearchResearch PersonnelResourcesRoleScreening procedureSeriesShapesSiteSleepSocial BehaviorSongbirdsSpeechStructureSynapsesSystemUnited States National Institutes of Healthbasebird songcDNA Librarycomparativecomparative genomicsdeafnessdigitalhigh throughput analysisimprovedinsightinterestmalemolecular markerneurochemistryneurogenesisneuronal excitabilityneuronal replacementnovelphotoperiodicitypromoterpublic health relevancereceptorrelating to nervous systemresearch studysexsexual dimorphismtooltraittranscription factortransgene expressionvocal learningvocalizationzebra finch
项目摘要
DESCRIPTION (provided by applicant): Songbirds are a leading model of neurobiological research with wide implications for understanding issues of human health and disease. They are among the few organisms that have evolved vocal learning, a complex trait that provides the basis of spoken language acquisition in humans. Studies of the ontogeny of songbird vocalizations and the organization of the brain circuitry that controls song learning and production have provided unique opportunities for uncovering the neural bases of vocal learning. Songbird research has also contributed novel insights into a broad range of fundamental questions in neurobiology, such as behaviorally- regulated gene expression, sex dimorphisms and the effects of sex steroids on brain structure and function, photoperiodicity and the regulation of seasonal brain plasticity, the role of sleep in learning, the neuroendocrine regulation of reproductive and social behaviors, and neurogenesis and neuronal replacement in adulthood. To help understand how the song control circuitry and birdsong behavior are shaped by genetic mechanisms, a wide set of modern molecular and genomic resources have recently become available to songbird researchers through NIH-funded initiatives; such resources include normalized brain cDNA libraries, comprehensive annotated EST databases, microarrays, a BAC library and the completed the zebra finch genome. Such resources have been instrumental in the rapid identification of genes and gene families of neurobiological interest, the study of gene structure and regulatory domains, high- throughput analysis of gene regulation through molecular profiling studies, and comparative genomics across the major higher vertebrate groups. A key next step in making full use of these genomic resources and understanding how genes relate to brain function and behavior in songbirds is to map gene expression in the context of functional brain circuits. To achieve this goal, we propose a single Specific Aim, namely to generate a Gene Expression Brain Atlas of the Zebra Finch. Specifically we propose to map the brain expression of a large set of genes (~2,500) that are of key importance to songbird and avian brain researchers, in register with a histological atlas, and make the data available as a web-based resource.
PUBLIC HEALTH RELEVANCE: This resource will have an enormous impact on further establishing songbirds as a major model organism for neurobiological research, and substantiating their relevance for human health and disease, in particular the neural basis of speech and language learning and impairment. It will provide a vastly improved molecular characterization of the zebra finch brain, allow for neurotransmitter and receptor profiling of song nuclei, and reveal how aene regulation mav be linked to the sona svstem. singing behavior and vocal learning.
描述(由申请人提供):鸣禽是神经生物学研究的领先模型,对于理解人类健康和疾病问题具有广泛的影响。它们是少数进化出声音学习的生物体之一,这是一种复杂的特征,为人类口语习得提供了基础。对鸣禽发声的个体发育和控制歌曲学习和产生的大脑回路组织的研究为揭示声音学习的神经基础提供了独特的机会。鸣鸟研究还为神经生物学中广泛的基本问题提供了新颖的见解,例如行为调节的基因表达、性别二态性以及性类固醇对大脑结构和功能的影响、光周期和季节性大脑可塑性的调节、学习中的睡眠、生殖和社会行为的神经内分泌调节以及成年期的神经发生和神经元替代。为了帮助理解鸣叫控制电路和鸟鸣行为是如何由遗传机制塑造的,最近通过美国国立卫生研究院资助的计划,鸣禽研究人员可以使用大量现代分子和基因组资源;这些资源包括标准化的大脑 cDNA 文库、综合注释的 EST 数据库、微阵列、BAC 文库和完整的斑胸草雀基因组。这些资源有助于快速鉴定具有神经生物学意义的基因和基因家族、基因结构和调控域的研究、通过分子谱研究对基因调控进行高通量分析以及主要高等脊椎动物群体的比较基因组学。充分利用这些基因组资源并了解基因如何与鸣禽的大脑功能和行为相关的关键下一步是绘制功能性大脑回路背景下的基因表达图谱。为了实现这一目标,我们提出了一个具体目标,即生成斑胸草雀的基因表达脑图谱。具体来说,我们建议绘制对鸣禽和鸟类大脑研究人员至关重要的大量基因(约 2,500 个)的大脑表达图谱,并与组织学图谱进行登记,并将数据作为基于网络的资源提供。
公共健康相关性:该资源将对进一步将鸣禽确立为神经生物学研究的主要模式生物,并证实它们与人类健康和疾病的相关性,特别是言语和语言学习和障碍的神经基础产生巨大影响。它将大大改善斑胸草雀大脑的分子特征,允许对鸣叫核的神经递质和受体进行分析,并揭示 aene 调节如何与声纳系统联系起来。歌唱行为和声乐学习。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Claudio V Mello其他文献
Claudio V Mello的其他文献
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{{ truncateString('Claudio V Mello', 18)}}的其他基金
Transition Support for ZEBrA, A Gene Expression Brain Atlas of the Zebra Finch
对斑胸草雀基因表达脑图谱 ZEBrA 的过渡支持
- 批准号:
9164865 - 财政年份:2016
- 资助金额:
$ 38.5万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
8444464 - 财政年份:2010
- 资助金额:
$ 38.5万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
8052763 - 财政年份:2010
- 资助金额:
$ 38.5万 - 项目类别:
A Gene Expression Brain Atlas of the Zebra Finch.
斑胸草雀的基因表达脑图谱。
- 批准号:
7873564 - 财政年份:2010
- 资助金额:
$ 38.5万 - 项目类别:
Estrogens and Central Auditory Processing of Birdsong
雌激素与鸟鸣的中枢听觉处理
- 批准号:
7599287 - 财政年份:2008
- 资助金额:
$ 38.5万 - 项目类别:
Molecular Profiling of Song Nucleus HVC in the Zebra Finch
斑胸草雀宋核 HVC 的分子分析
- 批准号:
7626809 - 财政年份:2008
- 资助金额:
$ 38.5万 - 项目类别:
Cellular and Synaptic Physiology of Auditory Processing
听觉处理的细胞和突触生理学
- 批准号:
7107951 - 财政年份:2005
- 资助金额:
$ 38.5万 - 项目类别:
Cellular and Synaptic Physiology of Auditory Processing
听觉处理的细胞和突触生理学
- 批准号:
6989257 - 财政年份:2005
- 资助金额:
$ 38.5万 - 项目类别:
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