HIV Susceptibility and Pathogenesis in the Female Genital Tract

女性生殖道的艾滋病毒易感性和发病机制

• 批准号: 8319582
• 负责人: Alan L Landay
• 金额: $ 216.86万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319582
• 关键词: AIDS prevention; Academic Medical Centers; Address; Area; Bacterial Infections; Baltimore; Benign; Biometry; Cervical; Chicago; Clinical; Collaborations; County; County Hospitals; Development; Disease; Doctor of Philosophy; Epidemiology; Estrogens; Exposure to; Female; Fostering; Genital system; HIV; HIV Infections; HIV therapy; Health Services; Heterosexuals; Hospitals; Host Defense; Illinois; Immunity; In Vitro; Individual; Infection; Institution; Intervention; Investigator-Initiated Research; Knowledge; Laboratories; Lead; Learning; Mediating; Microscopic; Modeling; Molecular; Mucosal Immunity; Mucous body substance; National Institute of Allergy and Infectious Disease; Operative Surgical Procedures; Participant; Pathogenesis; Patients; Pilot Projects; Predisposition; Reagent; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Role; Rwanda; Sampling; Sampling Studies; Science; Sexual Transmission; Signal Transduction; Source; Specimen; Tissues; Universities; Vaccine Clinical Trial; Woman; Work; cohort; cooking; design; enhancing factor; human female; improved; innovation; insight; interest; leukocyte activation; novel; novel strategies; prevent; programs; repository; research study; response; tissue culture; transmission process; virology

DESCRIPTION (provided by applicant): "HIV Susceptibility and Pathogenesis in the Female Genital Tract" is designed to study mechanisms of HIV infection that are unique to women. Its four investigator initiated projects are strongly interactive and focus on HIV in the female genital tract. Project I, Microscopic Analysis of the Interaction of HIV and the Human Female Genital Tract (Thomas Hope, PhD, NWU), studies HIV interaction with tissue and mucous in the female genital tract. Project II, HIV and Female Genital Tract Flora (Greg Spear, PhD, RUMC), studies the effect of bacterial infection in the genital tract on susceptibility to HIV infection. Project III, HIV-Specific Immunity in Highly Exposed Uninfected Women (Richard Novak, MD, UIC and Linda Baum, PhD, RUMC), studies the potential development of protective mucosal immunity that results from sexual exposure to HIV. Project IV, Role of Estrogen in HIV Transmission and Pathogenesis (Lena AI-Harthi, PhD, RUMC), studies the effects of estrogen mediated leukocyte activation and Wnt/p-catenin signaling on HIV transmission. Four cores foster the collaborative interactions between projects. Core A (Administrative Core) is directed by the Program Project PI, Alan Landay, PhD, RUMC. Core B (Clinical Core) directed by Audrey French, MD, Cook County, will provide samples from established cohorts of HIV infected women: the Women's Interagency HIV Study (WIHS), the Women at Heterosexual Risk Cohort (WISH) and HIV infected women from Rwanda (RWISA). When necessary, women of interest from these established cohorts will be recruited to provide additional samples. Core C (Tissue Culture and Virology Laboratory Core) directed by Nell Lurain, PhD, RUMC, will perform experiments with the HIV tissue explant replication model, prepare molecular and virologic reagents, and maintain a specimen repository. Core D (Biostatistics/Epidemiology Core) directed by Elizabeth Golub, PhD, JHU, will help project investigators plan studies and evaluate results. The synergy of effort among projects and cores is evident in aims that require participation of multiple investigators and resources provided by the cores. This PO1 will improve our understanding of factors that enhance or inhibit sexual transmission of HIV and will lead to the development of innovative interventions to prevent HIV.

描述（由申请人提供）：“女性生殖道的艾滋病毒易感性和发病机制”旨在研究女性特有的艾滋病毒感染机制。其四个研究者发起的项目具有很强的互动性，并重点关注女性生殖道中的艾滋病毒。项目 I，艾滋病毒与人类女性生殖道相互作用的微观分析（托马斯·霍普博士，西北大学）研究艾滋病毒与女性生殖道组织和粘液的相互作用。项目 II，艾滋病毒和女性生殖道菌群（Greg Spear，博士，RUMC）研究生殖道细菌感染对艾滋病毒感染易感性的影响。项目 III，高度暴露的未感染女性的 HIV 特异性免疫（UIC 的 Richard Novak 医学博士和 RUMC 的 Linda Baum 博士）研究了因性接触 HIV 而导致的保护性粘膜免疫的潜在发展。项目 IV，雌激素在 HIV 传播和发病机制中的作用（Lena AI-Harthi 博士，RUMC）研究雌激素介导的白细胞激活和 Wnt/p-catenin 信号传导对 HIV 传播的影响。四个核心促进项目之间的协作互动。核心 A（管理核心）由 RUMC 项目 PI Alan Landay 博士指导。核心 B（临床核心）由库克县医学博士 Audrey French 指导，将提供来自已建立的 HIV 感染女性队列的样本：妇女机构间 HIV 研究 (WIHS)、女性异性恋风险队列 (WISH) 和来自卢旺达（RWISA）。必要时，将从这些已建立的队列中招募感兴趣的女性来提供额外的样本。核心 C（组织培养和病毒学实验室核心）由 RUMC 的 Nell Lurain 博士指导，将使用 HIV 组织外植体复制模型进行实验，准备分子和病毒学试剂，并维护样本库。核心 D（生物统计学/流行病学核心）由约翰霍普金斯大学 Elizabeth Golub 博士指导，将帮助项目研究人员规划研究并评估结果。项目和核心之间努力的协同作用在需要多个研究人员参与和核心提供资源的目标中是显而易见的。该 PO1 将提高我们对增强或抑制 HIV 性传播因素的理解，并将导致预防 HIV 的创新干预措施的开发。