Translational Research Training Program in Environmental Health Sciences

环境健康科学转化研究培训计划

• 批准号: 8268083
• 负责人: Trevor M Penning
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268083
• 关键词: Environmental Health; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant) This is a resubmission of an application for a new Institutional Training Grant (T32) to support a Translational Research Training Program in Environmental Health Sciences for pre- and post- doctoral fellows at the University of Pennsylvania. The home for the Training Program will be the Center of Excellence in Environmental Toxicology (CEET) which is a P30 Environmental Health Sciences Core Center funded by NIEHS. The CEET is a Translational Environmental Health Sciences Center with a focus on major societal disease that affects the Philadelphia area: including but not limited to lung and airway disease, and reproductive, endocrinology, and developmental disorders (including the developmental basis of adult disease). Additionally, there is a strong emphasis on disease mechanism involving oxidative stress and gene-environment interactions. Pre-doctoral fellows, 2 per year, will be supported for three years bringing the steady state to 6 pre-doctoral fellows. Postdoctoral fellows preferably one Ph.D. and one M.D. will be appointed per year and will be supported for two years bringing the steady state to 4 postdoctoral fellows. Pre-doctoral fellows will be recruited to the investigators' umbrella program Biomedical Graduate Studies will be eligible to apply to the Certificate Program in Environmental Health Sciences which is a unique 2 year curriculum consisting of didactic course work and three rotations, one of which must be either a community-based research or population-based research rotation so that hands on training in environmental/molecular epidemiology is provided. Pre-doctoral fellows will be appointed to the Training Grant (TG) after completion of the first year of the Certificate Program. The training Program is distinct from the Certificate Program. All pre-doctoral fellows must take the Certificate Program but not all students in the Certificate Program will be supported by the Training Program. Those supported by the Training Program are expected to conduct thesis work in environmental health science that will be dual mentored by a basic and clinical scientist preceptor and will take additional course work in translational research training. Basic scientist postdoctoral fellows wishing to pursue clinical research on a disease of environmental etiology and clinician scientists wishing to pursue basic research on molecular and cellular mechanisms that lead to such disease will be appointed for up to two years. They will also be dual mentored. Postdoctoral fellows will be required to take at least four courses available to the Training Program pre-doctoral fellows to supplement their knowledge base. Postdoctoral fellows will also receive additional mentoring through the Career Development Core of the CEET. This Training Program provides the format for cross-fertilization and will provide a new cadre of environmental health scientist who may be equally well at home with the basic and clinical science of a problem. Trainees will be equipped to deal with environmental exposures, how they relate to disease and how their findings may be translated at the patient-, community- and public health- levels. Public Health Relevance: This Institutional Training Grant to establish a Translational Research Training Program in Environmental Health Sciences will create a new cadre of environmental health scientists trained to tackle major societal disease caused by environmental exposures at the patient and community, and public health level.

描述（由申请人提供） 这是对新机构培训补助金（T32）的申请，该申请支持宾夕法尼亚大学的前和博士后研究员环境健康科学的转化研究培训计划。培训计划的住所将是环境毒理学卓越的中心（CEET），这是由NIEHS资助的P30环境健康科学核心中心。 CEET是一个转化环境健康科学中心，重点是影响费城地区的主要社会疾病：包括但不限于肺和气道疾病，以及生殖，内分泌学和发育障碍（包括成人疾病的发育基础）。此外，非常重视涉及氧化应激和基因环境相互作用的疾病机制。每年2名的研究员将得到三年的支持，将稳定状态带到6名博士前研究员。博士后研究员最好是一位博士学位每年将任命一名医学博士学位，并将获得两年的支持，将稳态带到4个博士后研究员。 博士前的研究员将被招募到研究人员的雨伞计划生物医学研究生研究中，有资格适用于环境健康科学的证书计划，这是一项独特的2年课程，该课程由教学课程和三个轮换组成，其中之一必须是基于社区的研究或基于人口的研究研究或在环境中提供了基于人群的研究训练，以便在环境/分类中提供了培训。 证书计划的第一年完成后，博士前的研究员将被任命为培训补助金（TG）。 培训计划与证书计划不同。 所有博士前的研究员都必须参加证书计划，但并非所有证书计划中的学生都将得到培训计划的支持。培训计划支持的人有望在环境健康科学领域进行论文工作，该论文将由基本和临床科学家主持人双重指导，并将在翻译研究培训中获得其他课程。 基础科学家 希望对环境病因和临床医生进行临床研究的博士后研究员，希望对导致这种疾病的分子和细胞机制进行基础研究，最多将任命两年。他们也将受到双重指导。博士后研究员将必须至少参加四门课程，以补充其知识库。博士后研究员还将通过CEET的职业发展核心获得额外的指导。 该培训计划提供了交叉利用的格式，并将提供新的环境卫生科学家干部，他们可能同样在家中，具有问题的基本和临床科学。 学员将有能力处理环境暴露，与疾病的关系以及如何在患者，社区和公共卫生水平上翻译他们的发现。 公共卫生相关性：这项机构培训赠款旨在建立环境健康科学的转化研究培训计划，将创建一个新的环境健康科学家干部，该科学家培训了，培训，可以解决由患者和社区以及公共卫生水平的环境暴露引起的主要社会疾病。