Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

原发性进行性失语症失语症的康复和预防

基本信息

批准号：
8465050
负责人：
RHONDA B FRIEDMAN
金额：
$ 4万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8465050
关键词：
Anomia Area Atrophic Biological Preservation Brain imaging Clinical Cognitive Communication Dementia Diagnosis Disease Family Family Caregiver Future Genetic Transcription Goals Home environment Image Impaired cognition Impairment International Intervention Language Disorders Learning Life Maintenance Measures Memory Motor Names Nerve Degeneration Outcome Overlearning Patients Pattern Prevention Primary Progressive Aphasia Process Prophylactic treatment Psychological reinforcement Publishing Quality of life Reading Rehabilitation therapy Research Personnel Resistance Retrieval Semantic Dementias Staging Syndrome Techniques Testing Therapeutic Time Training Variant Writing base cerebral atrophy cognitive function design implicit memory improved interest language processing novel programs relating to nervous system remediation time interval treatment effect treatment response

项目摘要

DESCRIPTION (provided by applicant): The goal of this study is to remediate word-finding problems in patients with Primary Progressive Aphasia (PPA) and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which we attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. Patients with PPA whose naming of pictures has just begun to show signs of decline will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. A scene-description task containing trained items will be used to assess generalization. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Generalization to other exemplars and to other task situations is also predicted. In addition, we will image the brains of the patients to determine whether patterns of brain atrophy can be used to predict treatment response.

描述（由申请人提供）：这项研究的目的是补救主要进行性失语症患者（PPA）患者的单词调查问题，并延迟单词发现损害的进一步发展。当前的方法是新颖的，因为它包含了一种预防成分，我们试图加强保持功能性的神经连接，使它们随着疾病的发展而对降解的耐药性。尽管这项研究是针对单词调查问题的特定的，但成功的结果对于旨在预防或逆转痴呆症认知功能下降的其他研究将有良好的兆头。 PPA的患者的命名刚刚开始显示出下降的迹象，将在两个条件下以图片命名：查看图片并重复名称；并以书面名称查看图片，以及读写名称。将在训练后三个时间间隔中比较在每种情况下训练的图片的命名，并在研究前对图片进行命名，但从未接受过培训。一个包含训练有素的项目的场景描述任务将用于评估概括。可以预测，图片与其书面名称的配对，再加上编写名称的电动机任务，将使图片在以后的日期命名的能力更大，而不是简单地练习查看图片并重复名称。还预测了对其他示例和其他任务情况的概括。此外，我们将对患者的大脑进行成像，以确定是否可以使用脑萎缩模式来预测治疗反应。