Functional Architecture of Auditory Pathways from Inferior Colliculus to Cortex

从下丘到皮质的听觉通路的功能结构

• 批准号: 8372457
• 负责人: DOUGLAS C FITZPATRICK
• 金额: $ 32.94万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8372457
• 关键词: Address; Architecture; Area; Auditory; Auditory area; Auditory system; Brain; Cell Nucleus; Chiroptera; Cochlea; Cochlear Implants; Complex; Data; Disease; Echolocation; Electric Stimulation; Employee Strikes; Evaluation; Exhibits; Felis catus; Frequencies; Gerbils; Goals; Hearing; Hearing Impaired Persons; Hearing problem; Human; Inferior Colliculus; Knowledge; Medial; Midbrain structure; Monkeys; Neurons; Nuclear; Outcome; Output; Pathway interactions; Patients; Process; Property; Prosencephalon; Research; Role; Signal Transduction; Site; Speech; Staging; Stimulus; Structure; Structure-Activity Relationship; Tectum Mesencephali; Testing; Thalamic structure; Tinnitus; Work; auditory pathway; base; design; hearing impairment; research study; response; segregation

DESCRIPTION (provided by applicant): In the auditory system, striking transformations in the representations of stimuli occur between the auditory midbrain (inferior colliculus) and the auditory cortex. In all species, the single tonotopic representation in the central nucleus of the inferior colliculus (ICc) gives way to multiple tonotopic areas in the primary auditory cortex and these multiple cortical areas exhibit segregation of function. Because the transformations between the ICc and auditory cortex are fundamental, it is important to know where and how they occur. The proposed studies address 1) the anatomical projections from distinct parts of the central nucleus of the ICc to the tonotopic parts ('core" areas) of the medial geniculate (MG), and the projections from core areas of the MG to the auditory cortex and 2) evaluation of whether different pathways carry different information. An understanding of the organization of the multiple parallel pathways making up the ascending auditory system is a fundamental component for understanding the mechanisms of auditory function. This knowledge is expected to provide information that can be used in making rational choices of potential targets for direct brain stimulation in deaf patients who cannot use a cochlear prosthesis or in intractable disorders such as tinnitus. PUBLIC HEALTH RELEVANCE: Understanding the transformations that occur in auditory representations in the forebrain auditory pathways will be important for designs of speech processors for cochlear implant users, selecting targets for direct brain stimulation in deaf patients who cannot use a cochlear prosthesis, and in intractable disorders such as tinnitus.

描述（由申请人提供）：在听觉系统中，刺激表示中的引人注目的转换发生在听觉中脑（下丘）和听觉皮层之间。在所有物种中，下丘中心核（ICC）中的单个吨位表示，让位于主要听觉皮层的多个吨位区域，这些多个皮质区域表现出功能的分离。由于ICC和听觉皮层之间的转换是基本的，因此重要的是要知道它们在哪里以及如何发生非常重要。拟议的研究解决了1）从ICC中央核的不同部分到内侧基因概物（MG）的Tonotopic部位（“核心”区域）的解剖学投影。 以及从MG的核心区域到听觉皮层的预测以及2）评估不同途径是否具有不同的信息。了解组成上升听觉系统的多个平行路径的组织是了解听觉功能机制的基本组成部分。这些知识有望提供可用于在无法使用耳蜗假体或顽固性疾病（例如耳鸣）的聋患者中的潜在脑刺激的潜在脑刺激的合理选择。 公共卫生相关性：了解前脑听觉途径中听觉表示中发生的转换对于对耳蜗植入物用户的语音处理器设计至关重要，选择无法使用人工耳蜗假体的聋哑患者的直接脑刺激目标，以及诸如Tinnitus等棘手的疾病。