Diagnosis of Ovarian Cancer by Confocal Microendoscopy

共聚焦显微内窥镜诊断卵巢癌

基本信息

批准号：
8244655
负责人：
ARTHUR F. GMITRO
金额：
$ 5.54万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8244655
关键词：
Abdominal Cavity Area Biopsy Clinical Computer software Contrast Media Detection Development Diagnosis Disease Evaluation Fluorescence Funding Goals Greater sac of peritoneum Human Image Imagery Implant Laparoscopy Lesion Malignant Neoplasms Malignant neoplasm of ovary Mammalian Oviducts Methods Modality Molecular Profiling Noise Operative Surgical Procedures Optical Biopsy Optical Coherence Tomography Ovarian Ovary Ovum Performance Peritoneal Physicians Procedures Process Research Resolution Safety Sampling Errors Scanning Screening for Ovarian Cancer Sensitivity and Specificity Signal Transduction Staging Surveys System Technology Testing Time Tissues Translating Translations Validation Work abstracting clinical application clinical practice diagnostic accuracy imaging modality improved in vivo instrument instrumentation operation research clinical testing technology development validation studies

项目摘要

Abstract The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician with an immediate evaluation of tissue and to survey a much greater area of tissue, reducing the sampling error of traditional tissue extraction biopsy. A confocal microlaparoscope system was constructed and tested in vivo in humans during the prior funding period. A specific aim of this work is to now validate the system and show that it can be used to detect cancer of the ovary during a laparoscopic procedure. Additional objectives of the work are to expand the use of the instrument to the detection of peritoneal implants of ovarian cancer throughout the abdominal cavity and to develop and test a system capable of imaging inside the fallopian tubes. Further technical development is aimed at improving the confocal imaging performance and adding optical coherence tomography as a complimentary imaging modality. The new instrument will incorporate the two imaging modalities into a single compact probe with seamless and rapid switching between modes of operation. In addition to the technology development and clinical translation, another aim of the project is to develop and test targeted contrast agents that provide safer and more effective in vivo identification of ovarian cancer.

抽象的本研究的目的是进一步开发并临床验证用于卵巢癌体内诊断的实时多光谱共焦显微内窥镜。共焦显微内窥镜是一种在细胞水平上可视化组织的新型仪器，在光学活检方面显示出巨大的前景。共焦显微内窥镜有潜力为医生提供组织的即时评估并调查更大的组织区域，从而减少传统组织提取活检的采样误差。在先前的资助期间，构建了共焦显微腹腔镜系统并在人体体内进行了测试。这项工作的具体目的是验证该系统并表明它可用于在腹腔镜手术期间检测卵巢癌。工作的其他目标将扩大该仪器的使用范围，以检测整个腹腔内卵巢癌腹膜植入物，并开发和测试能够在输卵管内部成像的系统。进一步的技术开发旨在提高共焦成像性能并添加光学相干断层扫描作为补充成像方式。新仪器将两种成像模式整合到一个紧凑的探头中，并在操作模式之间无缝快速切换。除了技术开发和临床转化之外，该项目的另一个目标是开发和测试靶向造影剂，以提供更安全、更有效的卵巢癌体内识别。