Diagnosis of Ovarian Cancer by Confocal Microendoscopy

共聚焦显微内窥镜诊断卵巢癌

• 批准号: 8139552
• 负责人: ARTHUR F. GMITRO
• 金额: $ 4.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8139552
• 关键词: Abdominal Cavity; Area; Biopsy; Clinical; Computer software; Contrast Media; Detection; Development; Diagnosis; Disease; Evaluation; Fluorescence; Funding; Goals; Greater sac of peritoneum; Human; Image; Imagery; Implant; Laparoscopy; Lesion; Malignant Neoplasms; Malignant neoplasm of ovary; Mammalian Oviducts; Methods; Modality; Molecular Profiling; Noise; Operative Surgical Procedures; Optical Biopsy; Optical Coherence Tomography; Ovarian; Ovary; Ovum; Performance; Peritoneal; Physicians; Procedures; Process; Research; Resolution; Safety; Sampling Errors; Scanning; Screening for Ovarian Cancer; Sensitivity and Specificity; Signal Transduction; Staging; Surveys; System; Technology; Testing; Time; Tissues; Translating; Translations; Validation; Work; clinical application; clinical practice; diagnostic accuracy; imaging modality; improved; in vivo; instrument; instrumentation; operation; public health relevance; research clinical testing; technology development; validation studies

DESCRIPTION (provided by applicant): The objective of this research is to further develop and clinically validate a real-time multispectral confocal microendoscope for in vivo diagnosis of ovarian cancer. The confocal microendoscope is a new type of instrument for visualizing tissue at the cellular level and has shown great promise for performing optical biopsy. Confocal microendoscopy has the potential to provide a physician with an immediate evaluation of tissue and to survey a much greater area of tissue, reducing the sampling error of traditional tissue extraction biopsy. A confocal microlaparoscope system was constructed and tested in vivo in humans during the prior funding period. A specific aim of this work is to now validate the system and show that it can be used to detect cancer of the ovary during a laparoscopic procedure. Additional objectives of the work are to expand the use of the instrument to the detection of peritoneal implants of ovarian cancer throughout the abdominal cavity and to develop and test a system capable of imaging inside the fallopian tubes. Further technical development is aimed at improving the confocal imaging performance and adding optical coherence tomography as a complimentary imaging modality. The new instrument will incorporate the two imaging modalities into a single compact probe with seamless and rapid switching between modes of operation. In addition to the technology development and clinical translation, another aim of the project is to develop and test targeted contrast agents that provide safer and more effective in vivo identification of ovarian cancer. PUBLIC HEALTH RELEVANCE: The goal of this research is to demonstrate the clinical potential of the confocal microlaparoscope for the diagnosis of ovarian cancer. The confocal microlaparoscope is an instrument for performing optical biopsy of tissue. The technology was developed and clinically demonstrated in the context of ovarian cancer detection during the previous funding period. Continuing work is aimed at validating the clinical performance of the instrument for the detection of ovarian cancer and expanding the clinical applications to imaging of the fallopian tube and metastatic ovarian cancer in the peritoneal cavity. Work is also proposed to improve and expand the capability of the instrument and to develop targeted contrast agents that can be used safely and effectively in the clinical setting.

描述（由申请人提供）：这项研究的目的是进一步开发和临床验证实时的多光谱共聚焦微镜，用于体内卵巢癌的体内诊断。共聚焦微型内脏镜是一种在细胞水平上可视化组织的新型仪器，并显示出对进行光学活检的巨大希望。共聚焦微观镜检查可能会为医生立即评估组织并调查组织的更大面积，从而减少传统组织提取活检的采样误差。在先前的资金期间，在人类的体内构建和测试了共聚焦微脑镜系统。这项工作的一个具体目的是验证该系统，并表明它可以在腹腔镜手术过程中用于检测卵巢癌。这项工作的其他目标是将仪器的使用扩展到整个腹腔中卵巢癌的腹膜植入物，并开发和测试能够在输卵管内部成像的系统。进一步的技术开发旨在改善共聚焦成像性能，并添加光学相干断层扫描作为免费成像方式。新仪器将将两种成像模态纳入单个紧凑型探针中，并在操作模式之间进行无缝和快速切换。除技术开发和临床翻译外，该项目的另一个目的是开发和测试针对性的对比剂，从而为卵巢癌提供更安全，更有效的体内鉴定。 公共卫生相关性：这项研究的目的是证明共焦微脑镜在诊断卵巢癌中的临床潜力。共聚焦微脑镜是进行组织光学活检的仪器。该技术是在上一个资金期间在卵巢癌检测的背景下开发和临床证明的。持续工作旨在验证该仪器的临床性能，以检测卵巢癌，并将临床应用扩展到腹膜腔中输卵管和转移性卵巢癌的成像。还提出了工作，以提高和扩展仪器的能力并开发有针对性的对比剂，这些对比剂可以在临床环境中安全有效地使用。