Ultra-Miniature Multi-Modal Endoscopes

超小型多模态内窥镜

• 批准号: 7049691
• 负责人: ARTHUR F. GMITRO
• 金额: $ 15.77万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7049691
• 关键词: esophagus; fluorescence; lighting; model

DESCRIPTION (provided by applicant): The primary objectives of this research are: 1) to build ultra-miniature endoscopes with the capability for simultaneous diffuse white-light reflectance imaging and fluorescence imaging, and 2) to demonstrate unique scientific and clinical applications for these instruments. The catheter of the ultra-miniature endoscope will be based on existing fiber bundle and GRIN lens technology, but will require illumination down the central imaging channel. A novel NA-sharing optical design combined with polarization techniques, anti-reflection coatings, spectral confinement, and data processing will be used to overcome the inherent problem of background signal generated from illumination down the fiber bundle. A novel split-pupil concept will be employed in the system to achieve simultaneous multi-modal acquisition of color images and fluorescence images with high sensitivity. The development of the instrumentation is aimed at multiple scientific and clinical applications. One important scientific application is imaging the esophagus of a mouse model of Barrett's esophagus. During the R21 phase, the instrument concepts will be developed, endogenous diffuse reflectance and autofluorescence contrast will be measured in the mouse esophagus to optimize the system design, image contrast enhancement using exogenous contrast agents will be investigated, and the instrument will be used to evaluate in vivo imaging in mouse esophagus. Assuming the milestones are met, the R33 phase will entail building a fully functional multi-modal imaging instrument including catheters with the necessary functionality. A validation study will be carried out in mouse esophagus to demonstrate the scientific utility and efficacy of the instrument for this particular application. Additional studies will be carried with ex-vivo human tissue specimens and animal models to evaluate the feasibility and efficacy of the proposed clinical applications in bronchial and vascular imaging.

描述（由申请人提供）：这项研究的主要目标是：1）构建具有同时弥漫性白光反射成像和荧光成像的能力，以及2）以证明这些工具的独特科学和临床应用。超大型内窥镜的导管将基于现有的纤维束和咧嘴透镜技术，但需要在中央成像通道下照明。一种新型的NA共享光学设计，结合了极化技术，反射涂层，光谱限制和数据处理，以克服从光纤束下照明产生的背景信号的固有问题。系统中将采用一种新型的分裂学生概念，以实现具有高灵敏度的颜色图像和荧光图像的同时多模式采集。仪器的开发针对多种科学和临床应用。一个重要的科学应用是对巴雷特食管小鼠模型的食道成像。在R21阶段，将开发仪器概念，内源性扩散反射率和自动荧光对比度将在小鼠食道中进行测量，以优化系统设计，使用外源性对比剂的图像对比度增强，并将使用外源性对比剂，该仪器可用于在小鼠食管中评估体内的体内成像。假设满足里程碑，R33相将需要建立功能齐全的多模式成像仪器，包括具有必要功能的导管。将在小鼠食道中进行验证研究，以证明该仪器在该特定应用中的科学效用和功效。其他研究将使用前体的人体组织标本和动物模型进行，以评估拟议的支气管和血管成像中提出的临床应用的可行性和功效。