ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS

各族裔睡眠障碍与心血管健康的关联

基本信息

批准号：
8322017
负责人：
Susan S. Redline
金额：
$ 225.68万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-05 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8322017
关键词：
Accounting Address Affect African American Age Alcohol consumption Ancillary Study Ankle Apnea Arousal Asian Americans Atherosclerosis Autonomic nervous system Biochemical Breathing Calcium Candidate Disease Gene Cardiovascular Diseases Cardiovascular system Caucasians Caucasoid Race Chronic Circadian Rhythm Sleep Disorders Circadian Rhythms Clinical Collection Coronary artery Coronary heart disease Data Data Set Databases Diabetes Mellitus Disease Disease Outcome Dyslipidemias Employee Strikes Ethnic group Exposure to Future Gender Genetic Predisposition to Disease Genotype Health Heart failure High Prevalence Hispanics Home environment Hypertension Hypertrophy Hypoxemia Incidence Individual Inflammatory Intervention Intervention Studies Left Ventricular Dysfunction Left Ventricular Function Left Ventricular Hypertrophy Left Ventricular Mass Link Lipids Measurement Measures Medial Mental Depression Minority Minority Groups Modification Obesity Outcome Parents Participant Pathogenesis Pattern Phase Phenotype Physical activity Physiological Polysomnography Population Population Study Questionnaires Race Reading Records Research Resources Risk Risk Factors Role Sex Characteristics Sleep Sleep Apnea Syndromes Sleep Disorders Sleep Fragmentations Sleep Stages Sleep disturbances Slow-Wave Sleep Smoking Socioeconomic Status Stress Stroke Subgroup Testing Thick Time Variant Ventricular Function Woman Wrist actigraphy base cardiovascular disorder risk cohort design diabetes risk ethnic difference ethnic minority population fasting glucose genetic variant health disparity impaired glucose tolerance improved indexing men mortality neurophysiology nocturnal Hypoxemia novel racial and ethnic racial difference racial/ethnic difference sex shift work

项目摘要

DESCRIPTION (provided by applicant): Large differences in cardiovascular disease (CVD) outcomes have been observed across ethnic and gender groups which are not fully explained by consideration of traditional and novel CVD risk factors. For example, African Americans have a considerably higher prevalence of hypertension, left ventricular dysfunction, and heart failure than Caucasians despite lipid patterns and coronary artery calcium levels that generally show relatively favorable distributions. However, only limited research has addressed the role of sleep disorders in influencing CVD in ethnic minorities despite evidence that sleep disorders disproportionately affect minority populations and, through pro-inflammatory or autonomic nervous system dysregulation, operate as risk factors for hypertension and CVD. In this proposed ancillary study to the Multi-Ethnic Study of Atherosclerosis (MESA), we aim to perform standardized in-home polysomnography and 7-day wrist actigraphy in 2500 African American, Hispanic, Asian American and Caucasian individuals participating in MESA Exam 5 to derive indices of sleep apnea, quality, duration and timing. Newly collected sleep data will be rigorously standardized and comprehensively analyzed by a central Reading Center. By capitalizing on the rich clinical, physiological, anthropomorphic, and biochemical data collected longitudinally by MESA over 10 years, we will test the associations between indices of sleep apnea (apnea hypopnea index, nocturnal hypoxemia), sleep duration and quality, slow wave activity, and circadian placement with the indices of CVD risk, subclinical CVD and clinical CVD as outcomes. Finally, we will quantify the extent to which sleep disorders and patterns account for previously observed variations in CVD among ethnic and sex groups. By defining the role of sleep disorders in CVD in ethnic minorities, these activities may direct future interventions directed at reducing ethnic disparities in chronic health conditions.

描述（由申请人提供）：不同种族和性别群体之间观察到心血管疾病（CVD）结果存在巨大差异，考虑到传统和新型 CVD 危险因素并不能完全解释这一差异。例如，尽管血脂模式和冠状动脉钙水平通常表现出相对有利的分布，但非洲裔美国人的高血压、左心室功能障碍和心力衰竭的患病率明显高于白人。然而，只有有限的研究探讨了睡眠障碍对少数族裔心血管疾病的影响，尽管有证据表明睡眠障碍对少数族裔人群的影响不成比例，并且通过促炎或自主神经系统失调，成为高血压和心血管疾病的危险因素。在这项拟议的动脉粥样硬化多种族研究 (MESA) 辅助研究中，我们的目标是对参加 MESA 考试 5 的 2500 名非裔美国人、西班牙裔、亚裔美国人和白种人进行标准化家庭多导睡眠图和 7 天腕部活动记录仪，以得出睡眠呼吸暂停、质量、持续时间和时间的指标。新收集的睡眠数据将由中央阅读中心进行严格标准化和全面分析。通过利用MESA 10年来纵向收集的丰富临床、生理、拟人化和生化数据，我们将测试睡眠呼吸暂停指数（呼吸暂停低通气指数、夜间低氧血症）、睡眠持续时间和质量、慢波活动、以 CVD 风险、亚临床 CVD 和临床 CVD 指数作为结果的昼夜节律安排。最后，我们将量化睡眠障碍和模式在多大程度上解释了先前观察到的种族和性别群体之间的 CVD 差异。通过明确睡眠障碍在少数族裔心血管疾病中的作用，这些活动可能会指导未来的干预措施，以减少慢性健康状况的种族差异。