National Sleep Research Resource (NSRR)

国家睡眠研究资源 (NSRR)

基本信息

批准号：
9303430
负责人：
Susan S. Redline
金额：
$ 138.26万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-05 至 2019-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9303430
关键词：
Address Adult Algorithms Architecture Area Awareness Biochemical Biochemical Markers Brain Breathing Cardiopulmonary Cardiovascular Diseases Cardiovascular system Cataloging Catalogs Child Chronic Clinical Clinical Investigator Clinical Protocols Clinical Trials Cohort Studies Collection Communities Comorbidity Computers Data Data Analyses Data Collection Data Discovery Data Quality Data Set Data Storage and Retrieval Databases Disease Disease susceptibility Documentation E-learning Electrocardiogram Electroencephalography Ensure Epidemiologist Etiology European Frequencies Funding Generations Genetic Markers Genetic Predisposition to Disease Goals Health Heart Rate Heart failure Human Hypertension Improve Access Incidence Informatics Intuition Investments Knowledge Laboratories Libraries Link Lung diseases Mediator of activation protein Medicine Metabolic Diseases Metadata Methodology Methods Morbidity - disease rate Multicenter Studies National Heart, Lung, and Blood Institute Neurocognitive Online Systems Ontology Outcome Output Participant Pathogenesis Physiological Physiology Play Polysomnography Population Predisposition Privacy Procedures Pulmonary Heart Disease Reading Reporting Research Research Infrastructure Research Personnel Research Support Resources Retrieval Risk Risk Factors Role Sampling Scientific Advances and Accomplishments Scientist Secure Security Semantics Signal Transduction Site Sleep Sleep Apnea Syndromes Sleep Disorders Slow-Wave Sleep Software Engineering Standardization Stroke Structure Subgroup System Terminology Time Training United States National Institutes of Health Variant Work application programming interface cardiovascular risk factor clinically relevant cloud based cloud platform cohort computerized tools data access data format data integration data resource data sharing data visualization design diabetes risk disorder risk electronic data file format mortality neurophysiology novel obesity risk open source organizational structure quality assurance repository research study sensor signal processing statistics tool web interface webinar

项目摘要

DESCRIPTION (provided by applicant): Since 1994, NIH has supported the standardized collection of polysomnography (PSG) studies as part of landmark multi-center studies which have used well-defined methods for data collection and quality assurance. Across studies, information on disease risk factors and outcomes, cardiovascular and neurocognitive function, and biochemical marker data, are available for children and adults representing diverse backgrounds. These data could serve as an invaluable national resource, providing opportunities to engage the scientific community, including trainees, in efforts to discover predictive bio-physiological signals for disease incidence and progression and to address critical questions regarding disease susceptibility and subgroup differences not possible using data from single cohorts. Improved access to those data would add value to already funded projects, ensuring maximal and enduring impact. Optimal use of such data requires the systematic organization and structuring of these data and access to procedures and computational tools for easy but secure access and curation of well-defined data subsets. The NHLBI National Sleep Research Resource (NSRR) aims to meet these compelling needs, thus leveraging the NIH's investments in the collection of sleep data in well characterized cohort studies and clinical trial to create a unique national resource of reliably-scored, well-annotated research PSGs from many major NHLBI cohorts or clinical trials (~ 50,000 sleep studies). The NSRR also will include: a) an electronic database of polysomnography data (raw signals, scored annotations, and summary sleep metrics); b) quantitative metrics of heart rate and EEG signals; b) linked data on clinical, physiological and biochemical parameters; c) a tool set to allow the user to search and access de-identified research data using a secure, cloud platform; d) an open-source suite of tools for offline analyses for signal processing, file structure editing, data harmonization and statistic generation; and e) user support for resource usage. NSRR will be a scalable and expandable resource constructed by capitalizing on major advances in informatics, developed with leading-edge agile software engineering methodology, user-centered interface design and an ontology-driven architecture. RELEVANCE: The creation of a central library of well-defined sleep studies linked to clinical and physiological data will transform data sharing approaches across the scientific community, enhancing the ability of researchers to address critical questions regarding the role of sleep disorders in the etiology of chronic health conditions, such as cardiovascular disease and identify subgroups of the population at greatest risk for sleep disorders and their related co-morbidities.

描述（由申请人提供）：自 1994 年以来，NIH 一直支持多导睡眠图 (PSG) 研究的标准化收集，作为具有里程碑意义的多中心研究的一部分，这些研究使用明确的数据收集和质量保证方法。在各项研究中，代表不同背景的儿童和成人可以获得有关疾病危险因素和结果、心血管和神经认知功能以及生化标记数据的信息。这些数据可以作为宝贵的国家资源，为包括受训人员在内的科学界提供机会，努力发现疾病发生和进展的预测生物生理信号，并解决使用数据无法解决的有关疾病易感性和亚组差异的关键问题来自单个队列。改善对这些数据的访问将为已资助的项目增加价值，确保产生最大和持久的影响。此类数据的最佳使用需要对这些数据进行系统组织和结构化，并访问程序和计算工具，以便轻松但安全地访问和管理明确定义的数据子集。 NHLBI 国家睡眠研究资源 (NSRR) 旨在满足这些迫切的需求，从而利用 NIH 在特征明确的队列研究和临床试验中收集睡眠数据的投资，创建一个独特的国家资源，提供可靠评分、注释完善的研究来自许多主要 NHLBI 队列或临床试验（约 50,000 项睡眠研究）的 PSG。 NSRR 还将包括： a) 多导睡眠图数据电子数据库（原始信号、评分注释和摘要睡眠指标）； b) 心率和脑电图信号的定量指标； b) 临床、生理和生化参数的关联数据； c) 允许用户使用安全的云平台搜索和访问去识别化的研究数据的工具集； d) 一套开源工具，用于信号处理、文件结构编辑、数据协调和统计生成的离线分析； e) 用户对资源使用的支持。 NSRR 将是一个可扩展和可扩展的资源，利用信息学的重大进步构建，采用领先的敏捷软件工程方法、以用户为中心的界面设计和本体驱动的架构进行开发。相关性：创建一个与临床和生理数据相关的明确睡眠研究中央图书馆将改变整个科学界的数据共享方法，增强研究人员解决有关睡眠障碍在慢性病病因学中的作用的关键问题的能力。健康状况，如心血管疾病，并确定睡眠障碍及其相关并发症风险最高的人群亚群。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Difference in spectral power density of sleep electroencephalography between individuals without insomnia and frequent hypnotic users with insomnia complaints.

DOI：
10.1038/s41598-022-05378-6
发表时间：
2022-02-08
期刊：
Scientific reports
影响因子：
4.6
作者：
Kang JM;Cho SE;Moon JY;Kim SI;Kim JW;Kang SG
通讯作者：
Kang SG

Polysomnographic Measurement of Sleep Duration and Bodily Pain Perception in the Sleep Heart Health Study.

睡眠心脏健康研究中睡眠持续时间和身体疼痛感知的多导睡眠图测量。

DOI：
10.5665/sleep.6026
发表时间：
2016
期刊：
Sleep
影响因子：
5.6
作者：
Weingarten,JeremyA;Dubrovsky,Boris;Basner,RobertC;Redline,Susan;George,Liziamma;Lederer,DavidJ
通讯作者：
Lederer,DavidJ

The Role of Big Data in the Management of Sleep-Disordered Breathing.