Amblyopia in astigmatic children: Development and Treatment

散光儿童弱视的发展与治疗

• 批准号: 8312492
• 负责人: Erin M Harvey
• 金额: $ 82.8万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312492
• 关键词: Address; Amblyopia; Anatomy; Anterior; Astigmatism; Behavior; Child; Child Development; Chronic; Clinical; Complex; Cornea; Corneal Topography; Data; Databases; Development; Environment; Ethnic Origin; Evaluation; Eyeglasses; Form Perception; Future; Guidelines; High Prevalence; Hyperopia; Imaging technology; Infant; Instruction; Investigation; Letters; Literature; Measurement; Measures; Methods; Motion; Myopia; Native Americans; Natural experiment; Nursery Schools; Pattern; Performance; Population; Preschool Child; Prevention; Principal Investigator; Reading; Refractive Errors; Research; Research Personnel; School-Age Population; Schools; Screening procedure; Time; Toddler; Tribes; Vision; Visual; base; clinical care; compliance behavior; emmetropization; experience; infancy; insight; novel; programs; research study; social; vision development; visual motor; visual performance; visual-motor integration

Program Director/Principal Investigator (Last, First, Middle): Harvey, Erin M PROJECT SUIVIMARY (See instructions): The visual experience of the uncorrected astigmat provides a unique natural experiment on the effect of chronic blur on visual development. Studies of Tohono O'odham children, 30 to 40% of whom have visually significant astigmatism, provide a unique opportunity for investigation ofthe effects of astigmatism. The first aim is to study the stability of astigmatism in Tohono O'odham children over time, and to determine the anatomical origins of their astigmatism. Measurements of the posterior cornea will provide fundamental data on the origin of the internal astigmatism that often compensates for external (anterior) corneal astigmatism. The second aim is to determine how astigmats perform in the everyday complex visual environment. Specifically, we will examine the relation between astigmatic refractive error and (a) compliance with spectacle correction, (b) accommodation patterns, and (c) performance of complex perceptual tasks. By examining the influence of social, refractive, visual performance, and accommodation factors on compliance, we will provide a uniquely broad analysis of barriers to compliance, will provide essential information for development of strategies to increase treatment compliance in this population, and may identify barriers to compliance that are relevant to astigmats in general. Measures of accommodation under various task demand conditions will allow us to better understand how astigmats compensate for the unique persistent blur introduced by astigmatism, and will allow us to better understand how these strategies impact visual development. Finally, data on how astigmatism influences performance on tasks that require visual motor integration, reading fluency, and global perception of form and motion will provide valuable insight into how astigmatism impacts everyday functioning. In summary, access to this unique population of high astigmats introduces a valuable opportunity to conduct novel studies to further our understanding of the long-term stability and anatomic origins of astigmatism and to explore the effects of astigmatism on functioning in a complex visual environment. RELEVANCE (See instructions): This research will provide the first analysis of the anatomic origins of astigmatism in this population, generate important clinical information for development of guidelines for treatment and prevention of astigmatism-related amblyopia, and will further our understanding of the influence of astigmatism on visual functioning. Results will benefit astigmatic Tohono O'odham children and astigmatic children in general.

项目总监/首席研究员（最后、第一、中间）：Harvey, Erin M SUIVIMARY 项目（参见说明）： 未矫正散光的视觉体验为散光效果提供了独特的自然实验 视觉发育的慢性模糊。对 Tohono O'odham 儿童的研究显示，其中 30% 至 40% 的儿童患有视力障碍 显着的散光，为研究散光的影响提供了独特的机会。 第一个目标是研究 Tohono O'odham 儿童散光随时间的稳定性，并 确定其散光的解剖学起源。后角膜的测量将提供 关于通常补偿外部（前）散光的内部散光起源的基本数据 角膜散光。 第二个目标是确定散光在日常复杂视觉环境中的表现。 具体来说，我们将检查散光屈光不正与 (a) 依从性之间的关系 眼镜矫正，(b) 调节模式，以及 (c) 复杂感知任务的执行。经过 检查社交、屈光、视觉表现和调节因素对依从性的影响， 我们将对合规障碍进行独特的广泛分析，并提供必要的信息 制定策略以提高该人群的治疗依从性，并可能确定治疗的障碍 一般与散光相关的依从性。各种任务下的住宿措施 需求条件将使我们能够更好地了解散光如何补偿独特的持久性 散光引起的模糊，将使我们能够更好地理解这些策略如何影响视觉 发展。最后，有关散光如何影响需要视觉运动的任务表现的数据 整合性、阅读流畅性以及对形式和运动的整体感知将提供有价值的见解 散光影响日常功能。 总之，接触到这一独特的高散光人群提供了一个宝贵的机会 进行新颖的研究，以进一步了解长期稳定性和解剖学起源 散光并探讨散光对复杂视觉环境中功能的影响。 相关性（参见说明）： 这项研究将首次分析该人群散光的解剖学起源， 生成重要的临床信息，用于制定治疗和预防指南 散光相关性弱视，将进一步加深我们对散光对视力影响的认识 发挥作用。结果将使散光 Tohono O'odham 儿童和一般散光儿童受益。