Amblyopia in Astigmatic Children - Development & Treatment

散光儿童弱视 - 发展

• 批准号: 7943524
• 负责人: Erin M Harvey
• 金额: $ 88.01万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7943524
• 关键词: Accounting; Affect; Amblyopia; American Indians; Anatomy; Anterior; Astigmatism; Child; Child Development; Chronic; Clinical; Complex; Cornea; Data; Development; Ethnic Origin; Evaluation; Eyeglasses; Form Perception; Future; Growth; Guidelines; High Prevalence; Hyperopia; Individual; Infant; Instruction; Investigation; Literature; Measurement; Measures; Methods; Motion; Myopia; Native Americans; Natural experiment; Nursery Schools; Optics; Pattern; Performance; Population; Preschool Child; Prevention; Principal Investigator; Reading; Refractive Errors; Research; Research Personnel; Risk; School-Age Population; Schools; Screening procedure; Time; Toddler; Tribes; United States Public Health Service; Vision; Visual; Work; base; clinical care; compliance behavior; emmetropization; experience; infancy; insight; longitudinal database; programs; vision development; visual performance; visual-motor integration

DESCRIPTION (provided by applicant): The visual experience of the uncorrected astigmat provides a unique natural experiment on the effect of chronic blur on visual development. Studies of Tohono O'odham children, 30 to 40% of whom have visually significant astigmatism, provide a unique opportunity for investigation of the effects of astigmatism. The first aim of the proposed research is to determine factors associated with spectacle wearing compliance in Tohono O'odham children, which will provide essential information for the development of future strategies to increase treatment compliance. The second aim is to determine the effect of uncorrected astigmatism on both uncorrected and corrected performance of complex and everyday visual tasks (global perception of form and motion, visual motor integration, reading), and will provide insight into how astigmatism impacts everyday functioning and whether it affects the development of the ability to perform these tasks when the child is wearing best correction. The third aim is to examine the relation between the visual experience of uncorrected astigmatic children, taking into account task-specific accommodative patterns, and the specific patterns of best-corrected visual deficits that result. These data will allow us to better understand the complex relation between visual experience and visual development. Aims 2 and 3 will also provide valuable clinical information regarding the amount of uncorrected astigmatism necessary to significantly disrupt visual performance and the amount of astigmatism necessary to disrupt normal development of visual capabilities necessary to perform simple, complex, and everyday visual tasks. The final aim is to study the stability of astigmatism in Tohono O'odham children over time, and to determine the anatomical origins of their astigmatism. The research will examine long-term change in astigmatism in over 2,000 school-age children. In addition, measurements of the posterior cornea will provide fundamental data on the origin of the internal astigmatism that often compensates for external (anterior) corneal astigmatism. RELEVANCE (See Instructions): This research will will generate important clinical information to aid in the development of guidelines for treatment and prevention of astigmatism-related amblyopia, will further our basic understanding of the influence of visual experience on visual development, and will provide the first analysis of the anatomic origins of internal astigmatism in this population.

描述（由申请人提供）：未经校正的Astigmat的视觉体验提供了一个独特的自然实验，该实验涉及慢性模糊对视觉发展的影响。对Tohono O'Odham儿童的研究，其中30％至40％的人具有视觉上的散光，为研究散光的影响提供了独特的机会。拟议的研究的第一个目的是确定与Tohono O'Odham儿童佩戴奇观相关的因素，这将为发展未来的策略提供提高治疗依从性的基本信息。第二个目的是确定未校正的散光对复杂和日常视觉任务的未经校正和校正性能（全球对形式和运动的感知，视觉运动整合，阅读）的影响，并将提供有关散光的洞察力，即散光对日常运作以及在孩子身穿最佳校正时执行这些任务的发展如何影响日常功能。第三个目的是考虑到特定于任务的适应性模式以及导致最校正的视觉缺陷的特定模式，研究未经校正的散光儿童的视觉体验之间的关系。这些数据将使我们能够更好地了解视觉体验和视觉发展之间的复杂关系。 AIM 2和3还将提供有关严重破坏视觉性能的不矫正的散光量以及破坏正常开发的正常视觉能力发展所需的散光量所必需的，以执行简单，复杂和日常视觉任务所需的正常视觉能力。最终目的是研究随着时间的流逝，散光在Tohono O'Odham儿童中的稳定性，并确定其散光的解剖学起源。该研究将研究2,000多名学龄儿童的散光症的长期变化。此外，后角膜的测量将提供有关内部散光的起源的基本数据，这些数据通常可以补偿外部（前）角膜散光。相关性（请参阅说明）：这项研究将产生重要的临床信息，以帮助制定与散光相关的amblyopia的治疗和预防指南，将进一步我们对视觉体验对视觉发展的影响的基本理解，并将提供对这个人群内部敏锐主义的解剖学起源的首次分析。