AMBLYOPIA IN ASTIGMATIC CHILDREN-DEVELOPMENT & TREATMENT

散光儿童发育中的弱视

• 批准号: 6525182
• 负责人: Erin M Harvey
• 金额: $ 41.84万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6525182
• 关键词: Native Americans; amblyopia; astigmatism; child physical development; clinical research; comorbidity; cooperative study; eye disorder diagnosis; eye refractometry; health care service; human population study; human subject; human therapy evaluation; longitudinal human study; medical complication; medically underserved population; middle childhood (6-11); outcomes research; public health; vision aid; visual perception

DESCRIPTION: (Applicant's Abstract) Evidence from the scientific literature indicates that uncorrected astigmatism during childhood is associated with three types of amblyopia: (1) a difference in best-corrected acuity and contrast sensitivity for orthogonal gratings (meridional amblyopia or MA), (2) a difference in best-corrected acuity for orthogonally-oriented vernier acuity stimuli (also termed MA), and (3) a deficit in best-corrected recognition (letter) acuity. These data suggest the presence of a sensitive period for the development of astigmatism-related amblyopia. However, only limited information is available concerning factors that influence the development and treatment of astigmatism-related amblyopia. The lack of research regarding astigmatism-related amblyopia is most likely due to the low prevalence of astigmatism in most populations of children. However, a high prevalence of large amounts of astigmatism and astigmatism-related amblyopia has been documented in members of the Tohono O'Odham grade-school children are not currently wearing eyeglass correction. The presence of this large sample of uncorrected highly astigmatic children provides a unique opportunity for the study of the development and treatment of astigmatism-related amblyopia. The goals of the present study are: (1) to characterize vision deficits associated with astigmatism-related amblyopia (through measurements of grating acuity, vernier acuity, recognition acuity, and contrast sensitivity), (2) to identify factors influencing the development of astigmatism-related amblyopia (e.g., factors such as amount and type of astigmatism), and (3) to determine age-specific effects of glasses intervention on astigmatism-related amblyopia. The proposed study will provide valuable clinical information regarding the development and treatment of astigmatism-related amblyopia. In addition, it will provide a valuable public health service to members of the Tohono O'Odham.

描述：（申请人的摘要）来自科学文献的证据 表明童年时期未矫正的散光与 弱视的三种类型：（1）最佳矫正视力和视力的差异 正交光栅的对比敏感度（子午弱视或 MA），(2) 正交导向游标锐度的最佳校正锐度的差异 刺激（也称为 MA），以及 (3) 最佳校正识别能力的缺陷 （字母）敏锐度。这些数据表明存在敏感期 散光相关弱视的发展。但信息有限 有关影响发展和治疗的因素 散光相关的弱视。 缺乏关于散光相关弱视的研究很可能是由于 大多数儿童的散光患病率较低。然而， 大量散光和散光相关的患病率很高 Tohono O'Odham 小学的学生已被记录为弱视 孩子目前还没有戴眼镜矫正。这个的存在 未矫正高度散光儿童的大样本提供了独特的 研究发展和治疗的机会 散光相关的弱视。 本研究的目标是：（1）描述视力缺陷的特征 与散光相关的弱视有关（通过光栅测量 敏锐度、游标敏锐度、识别敏锐度和对比敏感度），(2) 至 确定影响散光相关弱视发展的因素 （例如，散光的数量和类型等因素），以及（3）确定 眼镜干预对散光相关弱视的年龄特异性影响。 拟议的研究将提供有关以下方面的有价值的临床信息： 散光相关弱视的发展和治疗。此外，它 将为 Tohono O'Odham 的成员提供有价值的公共卫生服务。