Diet and Breast Density over Time in US Chinese Women

美国华裔女性的饮食和乳房密度随时间的变化

• 批准号: 7623303
• 负责人: MARILYN TSENG
• 金额: $ 6.67万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7623303
• 关键词: Acculturation; Address; Affect; Age; Appearance; Area; Biological Assay; Breast; Breast Cancer Epidemiology; C-reactive protein; Characteristics; Chemoprevention; Chinese People; Chronic; DNA; Data; Data Collection; Development; Diet; Environment; Epidemiologic Studies; Event; Fibrinogen; Future; Genes; Genetic; Genetic Polymorphism; Genetic Risk; Genotype; Haplotypes; Immigrant; Individual; Inflammation; Inflammatory; Inflammatory Response; Interleukin-6; Intervention; Life; Life Experience; Life Style; Longitudinal Studies; Malignant Neoplasms; Mammography; Measurement; Measures; Menopause; Outcome; Parents; Participant; Predisposition; Prevention strategy; Process; Proteins; Psychoneuroimmunology; Psychosocial Stress; Public Health; Questionnaires; Receptors, Tumor Necrosis Factor, Type II; Risk; Risk Factors; Role; Sampling; Sampling Studies; Screening procedure; Serum; Single Nucleotide Polymorphism; Stress; Surveys; TNF gene; Time; Tumor Necrosis Factor-alpha; Variant; Woman; Work; breast density; cancer risk; cohort; density; experience; genetic epidemiology; human TNF protein; inflammatory marker; insight; interest; malignant breast neoplasm; migration; pre-clinical; programs; psychosocial; public health relevance; residence; social; stressor

DESCRIPTION (provided by applicant): Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur in foreign-born, US Chinese women could contribute to our understanding of how acculturation-related factors, particularly in adulthood, affect breast cancer risk. In a three-year longitudinal study (1 R01 CA106606-01A2), we are examining the association between acculturation-related dietary changes and breast density changes in a unique cohort of recently immigrated, US Chinese women. Because of its strong association with breast cancer risk, breast density, as measured by both the area of density and the percentage of total breast area with a mammographically dense appearance, represents a useful marker for breast cancer risk in epidemiologic studies. Here, we propose to include a consideration of genetic factors in order to investigate a mechanism by which psychosocial stress, as represented by life event and acculturative stressors, might interact with inflammation-related genes to increase breast density. Increasing evidence suggests that chronic inflammation is an important risk factor for cancer. Predisposition to a heightened inflammatory response may also underlie genetic tendencies towards breast cancer in some individuals. Inflammation is of interest as a predictor of breast cancer risk because preventive strategies could target inflammatory markers as well as factors known to increase inflammatory marker levels, such as psychosocial stress. While the role of psychosocial stress in breast cancer development remains controversial, previous studies did not consider the potential moderating effect of genetic factors. Studies addressing the role of stress and its interaction with genetic characteristics may be especially informative within Chinese immigrants because they experience substantial cultural and social disequilibration during the acculturation process. The proposed revision will: (1) examine associations among stress, inflammatory markers, and breast density among the 435 participants in the parent study, and (2) evaluate potential interaction between candidate pro-inflammatory genes and psychosocial stressors. Study participants are Chinese, pre-/peri-menopausal, of mammography screening age, with US residence <=20 years. Data collection for the parent study includes questionnaires, serum and DNA samples, and breast density measurements from screening mammograms. Psychosocial stressors are measured using the Life Experiences Survey and the Migration-Acculturation Stressor Scale. We propose to use these available samples and data to conduct: serum assays for tumor necrosis factor receptor 2 (TNFR2), interleukin-6 (IL6), IL1beta, c-reactive protein (CRP), and fibrinogen; genotyping for selected single nucleotide polymorphisms and haplotype tagging SNPs in five candidate pro-inflammatory genes (TNF-alpha, IL6, IL1beta, CRP, and beta-fibrinogen); and statistical analyses to evaluate associations and interactions among stress, inflammatory markers and gene polymorphisms, and breast density. PUBLIC HEALTH RELEVANCE: The proposed project will use a transdisciplinary approach, with expertise in breast cancer epidemiology, genetic epidemiology, and psychoneuroimmunology, to offer new insight into the effects of interactions between psychosocial and genetic factors on breast density and, hence, breast cancer risk. Findings regarding significant interactions will be incorporated into statistical analyses already planned for the parent study, and will inform future analyses to identify acculturation-related predictors of breast density in the study sample. On a broader level, findings can be used towards developing effective preventive strategies, including chemoprevention and stress reduction programs utilizing breast density as a pre-clinical outcome, and genetic risk determination with interventions targeted at new genotypes found to increase breast cancer risk.

描述（由申请人提供）：移民到美国后，中国妇女正在过渡到增加乳腺癌的风险。对外国出生的生活方式变化的理解，美国中国妇女可能有助于我们理解与文化相关的因素，特别是在成年期如何影响乳腺癌的风险。在一项为期三年的纵向研究（1 R01 CA106606-01A2）中，我们正在研究与文化相关的饮食变化与乳房密度变化与最近移民的美国中国妇女的独特队列中的关联。由于其与乳腺癌的风险有很强的关联，乳腺密度通过密度和乳腺X线乳腺X型乳腺肿瘤的百分比衡量，这是流行病学研究中乳腺癌风险的有用标记。在这里，我们建议包括对遗传因素的考虑，以研究一种机制，通过生命事件和适应性压力源代表的社会心理应激可能与炎症相关基因相互作用以增加乳腺密度。越来越多的证据表明，慢性炎症是癌症的重要危险因素。在某些个体中，对炎症反应增强的倾向也可能是对乳腺癌的遗传趋势。炎症是乳腺癌风险的预测因素，因为预防策略可以针对炎症标志物以及已知会增加炎症标志物水平（例如社会心理压力）的因素。虽然社会心理压力在乳腺癌发育中的作用仍然存在争议，但先前的研究并未考虑遗传因素的潜在调节作用。解决压力的作用及其与遗传特征的相互作用的研究可能在中国移民中特别有用，因为他们在适应过程中经历了实质性的文化和社会不平衡。拟议的修订将：（1）检查父母研究中435名参与者之间的压力，炎症标记和乳房密度之间的关联，（2）评估候选促炎基因与社会心理压力源之间的潜在相互作用。研究参与者是中国人，乳房X线摄影筛查年龄的中文/期限为中国，我们的住所<= 20年。父母研究的数据收集包括问卷，血清和DNA样品以及筛查乳房X线照片的乳房密度测量。使用生活经验调查和迁移 - 培养应激量量表来测量社会心理压力源。我们建议使用这些可用的样品和数据进行：肿瘤坏死因子受体2（TNFR2），白介素6（IL6），IL1BETA，C-反应蛋白（CRP）和纤维蛋白原的血清测定；在五个候选促炎基因（TNF-Alpha，IL6，IL1BETA，CRP和β-纤维蛋白原）中，用于选定的单核苷酸多态性和单倍型SNP的基因分型；和统计分析，以评估压力，炎症标记和基因多态性以及乳房密度之间的关联和相互作用。公共卫生相关性：拟议的项目将采用跨学科方法，并具有乳腺癌流行病学，遗传流行病学和心理肌免疫学方面的专业知识，为心理和遗传因素对乳房密度之间的相互作用以及乳腺癌风险提供了新的见解。有关重大相互作用的发现将纳入已经计划的父母研究的统计分析中，并将为未来的分析提供信息，以确定研究样本中乳腺密度的与文化相关的预测指标。在更广泛的水平上，可以将发现用于制定有效的预防策略，包括使用乳房密度作为临床前结果的化学预防和减轻压力计划，以及针对新基因型的干预措施确定遗传风险，以增加乳腺癌风险。