Diet and Breast Density over Time in US Chinese Women

美国华裔女性的饮食和乳房密度随时间的变化

• 批准号: 7249333
• 负责人: MARILYN TSENG
• 金额: $ 50.77万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249333
• 关键词: Acculturation; Address; Adopted; Adoption; Affect; Age; American; Area; Behavior; Behavioral; Chinese American; Chinese People; Clinical; Communities; Data Collection; Diet; Dietary intake; Ethnic Origin; Generations; Health Transition; Insulin-Like Growth Factor I; Intervention Trial; Life Style; Longitudinal Studies; Mammography; Measures; Mediating; Menopause; Philadelphia; Population; Questionnaires; Recruitment Activity; Reproductive Health; Reproductive History; Research; Risk; Risk Factors; Risk Marker; Sampling; Screening procedure; Serum; Somatomedins; Thinking; Time; Weight; Woman; Work; age related; behavioral health; breast density; cancer risk; day; experience; follow-up; malignant breast neoplasm; migration; residence; success

Upon migration to the US, Chinese women undergo a transition to increased risk for breast cancer. An understanding of lifestyle changes that occur over time in foreign-born Chinese American women, such as changes in diet, could contribute to our understanding of how acculturative changes, particularly in adulthood, affect breast cancer risk. Breast density represents an especially useful marker of risk because of its strong association with breast cancer, and because change in breast density over time may reflect the effects of recent behaviors and exposures. The objectives of the proposed study are to characterize for the first time changes in diet and breast density over time in first-generation Chinese American women, and to examine dietary and other correlates of change in breast density. We will recruit 420 pre- or peri-menopausal Chinese American women of screening mammography age with US residence <=7 years. Data collection will include baseline questionnaires on dietary intake, acculturation, and health and reproductive histories; 4-day dietary recalls; anthropometric measures; serum insulin-like growth factor-l level; and a screening mammogram assessed for breast density. Two follow-up measures of the same factors will be obtained at 12- to 24-month intervals. Changes in diet, other behavioral factors, and breast density will be described, as well as dietary and other correlates of breast density change. The research team and the presence of a sizable Chinese American community in the Philadelphia area offer a first opportunity to examine changes in diet and breast density over time in a unique sample of first-generation Chinese American women. Findings will address the extent to which acculturation-related lifestyle changes contribute to the transition in breast cancer risk experienced by Chinese American women. They will also address the issue of modifiability of breast cancer risk in women regardless of ethnicity by examining changes in risk factors during adulthood and by identifying the specific factors of greatest importance.

移民到美国后，中国妇女经历了增加乳腺癌风险的过渡。对外国出生的美国妇女（例如饮食的变化）随着时间的流逝发生的生活方式变化的理解可能有助于我们理解适应性变化，尤其是在成年期间如何影响乳腺癌的风险。乳房密度代表了风险的特别有用的标志，因为它与乳腺癌有很强的关联，并且由于随着时间的流逝而变化可能反映了最近行为和暴露的影响。拟议研究的目标是在第一代美国妇女中首次表征饮食和乳房密度随着时间的流逝而变化，并检查饮食和其他乳房密度变化的相关性。我们将招募420名前或绝经期华裔美国妇女筛查乳房X线摄影年龄<= 7年。数据收集将包括有关饮食摄入，适应以及健康和生殖历史的基线问卷； 4天饮食召回；人体测量值；血清胰岛素样生长因子L水平；以及评估乳房密度的乳房X线照片。将以12到24个月的间隔获得相同因素的两个随访措施。将描述饮食，其他行为因素和乳房密度的变化，以及乳房密度变化的饮食和其他相关性。研究小组以及在费城地区有一个相当大的美国社区的存在，这是第一个机会，在独特的第一代美国妇女的独特样本中检查饮食和乳房密度随着时间的流逝而变化。调查结果将解决与文化相关的生活方式的变化在多大程度上导致了美国妇女经历的乳腺癌风险过渡的程度。他们还将通过检查成年期间的风险因素变化并确定最重要的特定因素，从而解决妇女乳腺癌风险的可修改性问题。