Examining the Gut Microbiome in Haitians Post-Migration to the United States

检查海地人移居美国后的肠道微生物组

基本信息

批准号：
10523853
负责人：
Dany Fanfan
金额：
$ 13.62万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10523853
关键词：
Acculturation Achievement Address Adopted Anxiety Area Asian population Behavior Behavior Therapy Bioinformatics Biological Process Characteristics Cohort Studies Country Cultural Characteristics Development Diet Habits Dietary Practices Economic Burden Education Employment Exposure to Fatigue Foundations Future Genomics Goals Haitian Health Health Promotion Healthy Eating Home Household Immigrant Immigration Income Intervention Knowledge Latino Population Length Life Style Link Mental Depression Mentors Nursing Research Outcome Pain Personal Satisfaction Persons Phylogenetic Analysis Physical activity Play Policies Population Psyche structure Quality of life Reduce health disparities Reporting Research Research Personnel Ribosomal RNA Risk Role Science Senior Scientist Services Social Environment Social Identification Stress Subgroup Symptoms Time Training Translating Underserved Population United States Work base biobehavior disability ethnic minority experience functional disability gut microbiome gut-brain axis health disparity health equity holistic approach improved microbial microbial genome microbiome composition microbiota migration perceived stress personalized intervention psychological distress psychosocial residence social culture social health determinants sociodemographic factors sociodemographics stool sample stressor symptom science tool translational research program

Acculturation Achievement Address Adopted Anxiety Area Asian population Behavior Behavior Therapy Bioinformatics Biological Process Characteristics Cohort Studies Country Cultural Characteristics Development Diet Habits Dietary Practices Economic Burden Education Employment Exposure to Fatigue Foundations Future Genomics Goals Haitian Health Health Promotion Healthy Eating Home Household Immigrant Immigration Income Intervention Knowledge Latino Population Length Life Style Link Mental Depression Mentors Nursing Research Outcome Pain Personal Satisfaction Persons Phylogenetic Analysis Physical activity Play Policies Population Psyche structure Quality of life Reduce health disparities Reporting Research Research Personnel Ribosomal RNA Risk Role Science Senior Scientist Services Social Environment Social Identification Stress Subgroup Symptoms Time Training Translating Underserved Population United States Work base biobehavior disability ethnic minority experience functional disability gut microbiome gut-brain axis health disparity health equity holistic approach improved microbial microbial genome microbiome composition microbiota migration perceived stress personalized intervention psychological distress psychosocial residence social culture social health determinants sociodemographic factors sociodemographics stool sample stressor symptom science tool translational research program

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项目摘要

ABSTRACT. Haitians comprise one of the fastest growing subgroups of immigrants in the US. These immigrants experience high levels of psychological distress (i.e., depression, anxiety, fatigue, and pain), contributing to progressive functional impairment, disability, economic burden, and poor long-term health outcomes. Knowledge of factors contributing to psychological distress early in the post-migration period and longitudinally will help inform type and timing of interventions to reduce the disabling effects of psychological distress and improve quality of life for this underserved population. Yet no studies have examined psychological distress and its underlying biobehavioral, psychosocial, and cultural characteristics in Haitian immigrants within the first few months of residence in the US or over time. While multiple biological processes may be associated with psychological distress, rising evidence suggests that gut microbiome (GM) diversity and composition play an important role via the bidirectional microbiome-gut-brain axis. After migration, changes in GM composition and diversity embody changes in the social determinants of health ([SDoH]; e.g., stress, sociodemographic factors, lifestyle behaviors, dietary patterns, acculturation, environmental and sociocultural conditions) that also contribute to risk for psychological distress. With more time in the US, the GM of recent immigrants becomes more Westernized, with reductions of microbial phylogenetic diversity and native GM species as well as genera-level shifts in microbiota abundance. The SDoH that drive these GM changes are modifiable through culturally responsive interventions. The GM thus has the potential to serve as both an early indicator of risk for psychological distress and a tool to mitigate its effects. The overall goal for this longitudinal pilot cohort study is to investigate associations between psychological distress, GM composition/diversity, and post-migration SDoH in recent Haitian immigrants to the US. Specific aims are to 1) Characterize the GM in 60 recent Haitian immigrants by analyzing self-collected stool samples at T1 (< 6 months in the US) and T2 (6 months after T1) and describe changes in composition/diversity over time and 2) Examine longitudinal associations between post-migration SDoH, GM composition/diversity, and psychological distress among recent Haitian immigrants. I hypothesize that, in recent Haitian immigrants, a) migration to the US is associated with changes in GM composition and diversity over time, and b) changes in GM composition and diversity are associated with changes in post-migration SDoH and psychological distress. The PI has assembled an interdisciplinary mentoring team of senior scientists with expertise in symptom science, GM, biocultural approaches, immigrant health disparities, genomics, and bioinformatics. This project will provide the foundation for the PI to build an independent translational research program focused on developing culturally responsive targeted interventions that mitigate psychological distress, improve long-term health outcomes, reduce health disparities, and increase health equity in ethnic-minority immigrant populations.

抽象的。海地人是美国移民成长最快的亚组之一。这些移民经历了高水平的心理困扰（即抑郁，焦虑，疲劳和疼痛），促进渐进的功能障碍，残疾，经济负担和长期健康状况不佳结果。了解在移民后初期导致心理困扰的因素和纵向将有助于告知干预措施的类型和时机，以减少心理的残疾影响苦恼和改善服务不足的人群的生活质量。但是没有研究心理困扰及其基本的生物行为，心理社会和文化特征在美国居住的头几个月内或随着时间的推移，移民。而多个生物过程可能与心理困扰有关，证据的增加表明肠道微生物组（GM）多样性和组成通过双向微生物组 - 脑轴发挥着重要作用。迁移后， GM组成和多样性的变化体现了健康的社会决定因素的变化（[SDOH]；例如，压力，社会人口统计学因素，生活方式行为，饮食模式，适应，环境和环境社会文化条件）也导致心理困扰的风险。随着美国的更多时间，最近移民的GM被更西化，随着微生物系统发育多样性的减少和本地通用汽车物种以及微生物群丰度的属性转移。驱动这些通用汽车的SDOH 通过文化响应式干预措施可以改变变化。因此，通用汽车有潜力两者都是心理困扰风险的早期指标，也是减轻其影响的工具。总体目标这项纵向飞行员队列研究是为了调查心理困扰，通用汽车之间的关联组成/多样性以及最近海地移民的移民SDOH。具体目标是1）通过分析T1的自我收集的粪便样本，在60名最近的海地移民中表征GM（<6）在美国和T2（T1之后6个月）的月份，并描述了随着时间的时间的组成/多样性的变化和2）检查移民后SDOH，GM组成/多样性与心理学之间的纵向关联最近海地移民的困扰。我假设，在最近的海地移民中，a）移民到美国与GM组成和随着时间的多样性的变化有关，b）GM组成的变化多样性与移民后SDOH和心理困扰的变化有关。 Pi具有组建了一个跨学科指导团队，由高级科学家组成，具有症状科学专业知识，通用汽车，生物文化方法，移民健康差异，基因组学和生物信息学。该项目将提供 PI建立独立翻译研究计划的基础，旨在在文化上发展响应敏感的针对性干预措施减轻心理困扰，改善长期健康结果，减少健康差异，并增加族裔移民人口中的健康平衡。