Dietary Soy/Isoflavones and Urinary Estrogen Metabolites

膳食大豆/异黄酮和尿液雌激素代谢物

• 批准号: 6492690
• 负责人: MARILYN TSENG
• 金额: $ 8.5万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6492690
• 关键词: DNA damage; biomarker; breast neoplasms; cancer prevention; cancer risk; clinical research; dietary constituent; estrogen analog; estrogens; female; flavones; human subject; nutrient intake activity; nutrition related tag; ovary neoplasms; phytoestrogens; questionnaires; soybeans; steroid hormone metabolism; urinalysis

DESCRIPTION (provided by applicant): Research on potential cancer-protective effects of soy and isoflavones has led to an increase in the availability and consumption of soy products in the US. Yet conflicting scientific evidence raises the concern that high levels of intake might actually increase breast cancer risk. Whether current levels of soy and soy isoflavone intake are sufficiently high to affect breast cancer risk is unknown largely because of a lack of convenient, current, and validated methods of assessing intake. The objectives of the proposed study are to (1) evaluate the validity of overnight urine samples as a method of assessing soy isoflavone intake, and (2) examine associations between soy/isoflavone intake and urinary estrogen metabolites. Participants will be drawn from a program at Fox Chase Cancer Center for women at high breast or ovarian cancer risk. The study will include 50 women with either very high or low soy intake based on questionnaire data. Participants will complete a soyfood questionnaire and provide four 24-hour urine specimens over a one month period, with overnight samples collected in separate containers. Urines will be analyzed for isoflavones, primarily daidzein and genistein, and for estrogen metabolites including 2-, 4-, and 16alpha-hydroxy estrogens. Isoflavone levels in overnight urine samples will be evaluated for validity by examining their correlations with isoflavone levels in 24-hour urine specimens. We will use multiple linear regression to examine associations of soy/isoflavone intake with urinary estrogen metabolites. The proposed research will provide useful information towards assessment of soy/isoflavone intake in a non-Asian sample. It is also an opportunity to add to limited knowledge on soy/isoflavone intake and its association with urinary estrogen metabolites as markers of breast cancer risk. Findings from this research will contribute information towards a soy supplementation trial to evaluate modification of soy/isoflavone intake as a means of reducing risk of breast cancer, a disease for which few preventive measures are available.

描述（由申请人提供）： 大豆和异黄酮的潜在癌症保护作用的研究已 在美国增加了大豆产品的可用性和消费。 然而，矛盾的科学证据引起了人们的关注，即高水平 摄入实际上可能会增加乳腺癌的风险。当前水平是否 大豆和大豆异黄酮的摄入量足以影响乳腺癌 风险在很大程度上是由于缺乏方便，当前和 经过验证的评估摄入方法。拟议研究的目标 是（1）评估隔夜尿液样品的有效性 评估大豆异黄酮的摄入量，（2）检查 大豆/异黄酮摄入量和尿雌激素代谢产物。参与者会 从高乳房或 卵巢癌风险。这项研究将包括50名非常高或很高的女性 基于问卷数据的大豆摄入量低。参与者将完成 大豆食品问卷调查并提供四个24小时的尿液标本 一个月期，在单独的容器中收集了隔夜样品。尿液 将分析异黄酮，主要是戴兹蛋白和染料木黄酮，以及 雌激素代谢物，包括2-，4-和16Alpha-Hydroxy雌激素。异黄酮 通过检查，将评估过夜尿液样品的水平 它们与24小时尿液标本中的异黄酮水平的相关性。我们将 使用多个线性回归检查大豆/异黄酮的关联 用尿雌激素代谢物摄入。拟议的研究将提供有用的信息，以评估非亚洲的大豆/异黄酮摄入量 样本。这也是增加有限知识的机会 大豆/异黄酮摄入及其与尿雌激素代谢物的关联 乳腺癌风险的标志。这项研究的结果将有助于 向大豆补充试验进行的信息，以评估 大豆/异黄酮摄入量是降低乳腺癌风险的一种手段 为此，很少有预防措施可用。