Diet & Activity Community Trial: High-Risk Colon Polyps

饮食

基本信息

批准号：
7493806
负责人：
JAMES R HEBERT
金额：
$ 57.24万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7493806
关键词：
Address Adenomatous Polyps Affect Africa African American American Appendix Attention Baptist Church Biological Blood Pressure Body Weight Case-Control Studies Church Collaborations Colon Carcinoma Colonic Polyps Colonoscopy Communities Community Networks Community Trial Diagnosis Diet Dietary Factors Disease Education Effectiveness Effectiveness of Interventions End Point Epidemiologic Studies European Family Family member Funding Future Goals Health Status Incidence Individual Inflammatory Intervention Intervention Trial Investigation Laboratory Animals Lesion Malignant Neoplasms Measures Methods Missionary Nature Outcome Participant Persons Physical activity Polyps Population Primary Prevention Process Public Health Publications Rate Recurrence Research Research Design Research Project Grants Risk Scientist Screening procedure South Carolina Staging Testing Universities Woman Work base cancer health disparity cancer risk college colon carcinogenesis community based participatory research design disease natural history experience health disparity prevent response

项目摘要

DESCRIPTION (provided by applicant): South Carolina has some of the largest health disparities in the nation, and the most dramatic of these are associated with elevated cancer rates among African Americans (AA). Colon cancer is the most deadly of the more common cancers. It also is the one most amenable to primary prevention by screening, with colonoscopy being the most effective screening procedure by far. Over the past two years the NCI-funded South Carolina Cancer Disparities Community Network (SCCDCN) has worked with its community partners to identify, and then reduce, cancer disparities that disproportionately burden the African-American community. This proposal is the product of the collaboration developed between the University of South Carolina and SCCDCN's community partners, through our Community Advisory Group/ Steering Committee, to design and develop a community-based participatory research project aimed at addressing the problem of colon cancer in African Americans in our state. Because colon cancer proceeds through the stage of colon polyps, screening represents both an excellent means of primary prevention and way of identifying persons at high risk of polyp recurrence and, by logical extension, colon cancer. Additionally, it is suspected that diet and physical activity may affect colon carcinogenesis very early in the natural history of the disease. The overall goal of this project, i.e., to reduce colon cancer-related health disparities, will be achieved by these Primary Aims: 1) to conduct a faith-based community-designed, church-based screening to identify individuals having colon polyps; 2) to remove polyps detected in the screening process (thereby preventing their transition to cancer and to provide biological material for future studies); 3) to conduct a case-control study designed collaboratively by the faith based community and USC scientists to identify factors associated with the presence of polyps; and 4) to design and conduct a study to test the effectiveness of a community-designed, family-based dietary and physical activity intervention aimed at modifying levels of inflammatory markers associated with CoCA risk. Because of the participatory, community-based nature of this study, we have identified a Secondary Aim - to test the effectiveness of the dietary and PA intervention on blood pressure, and body weight - that will be studied in both the primary study participants (i.e., subjects with polyps detected) and their family members This participatory case-control study and intervention trial represents a collaboration between a high-risk community and an academic team highly experienced in all aspects of research design, implementation, analyses, interpretation, and publication/dissemination of study results.

描述（由申请人提供）：南卡罗来纳州的健康差异是全国最大的，其中最显着的差异与非裔美国人 (AA) 癌症发病率升高有关。结肠癌是最常见的癌症中最致命的。它也是最适合通过筛查进行一级预防的方法，结肠镜检查是迄今为止最有效的筛查程序。在过去的两年里，NCI 资助的南卡罗来纳州癌症差异社区网络 (SCCDCN) 与其社区合作伙伴合作，确定并减少给非裔美国人社区带来不成比例负担的癌症差异。该提案是南卡罗来纳大学和 SCCDCN 社区合作伙伴通过我们的社区咨询小组/指导委员会合作开发的产物，旨在设计和开发一个基于社区的参与性研究项目，旨在解决非洲的结肠癌问题我们州的美国人。由于结肠癌经过结肠息肉阶段，因此筛查既是一级预防的极好手段，也是识别息肉复发高风险人群的方法，并通过逻辑延伸，识别结肠癌高风险人群。此外，人们怀疑饮食和体力活动可能会在疾病自然史的早期影响结肠癌的发生。该项目的总体目标，即减少结肠癌相关的健康差异，将通过以下主要目标来实现：1) 进行基于信仰的社区设计、以教会为基础的筛查，以识别患有结肠息肉的个体； 2）去除筛查过程中检测到的息肉（从而防止其转变为癌症，并为未来的研究提供生物材料）； 3) 进行由信仰社区和南加州大学科学家合作设计的病例对照研究，以确定与息肉存在相关的因素； 4) 设计并开展一项研究，以测试社区设计、以家庭为基础的饮食和身体活动干预措施的有效性，该干预措施旨在改变与 CoCA 风险相关的炎症标志物水平。由于这项研究的参与性、基于社区的性质，我们确定了一个次要目标 - 测试饮食和 PA 干预对血压和体重的有效性 - 将在主要研究参与者（即这项参与性病例对照研究和干预试验代表了高风险社区和在研究设计、实施、分析、解释和出版等各个方面经验丰富的学术团队之间的合作/传播研究结果。