Reducing Depressive Symptoms in Systemic Lupus Erythematosus

减少系统性红斑狼疮的抑郁症状

基本信息

批准号：
8264379
负责人：
CAROL MARIE GRECO
金额：
$ 32.4万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8264379
关键词：
Accounting Address Adult Affect African American Aftercare Anguish Antigens Area Arthralgia Attention Attenuated Autoimmune Diseases Behavior Behavior Therapy Binding Biological Markers Biomedical Research Caucasians Caucasoid Race Cells Chronic Chronic Disease Cognitive Therapy Complement Activation Complex Control Groups Counseling Depressive disorder Disease Distress Dose Educational Intervention Endogenous depression Epidemiologic Studies Equipment and supply inventories Etiology Evaluation Fatigue Female Flare Future General Population Great Britain Guided imagery Health Healthcare Hospitalization Immune Immune response Incidence Inflammation Inflammatory Intervention Investigation Lead Lupus Major Depressive Disorder Measures Mediator of activation protein Medical Mental Depression Mental Health Mind-Body Intervention Mind-Body Method Musculoskeletal Diseases Myalgia National Institute of Arthritis and Musculoskeletal and Skin Diseases Organ Outcome Outcome Measure Pain Participant Patients Pharmaceutical Preparations Pilot Projects Population Publishing Randomized Randomized Controlled Trials Relapse Relaxation Research Rheumatism Sampling Self Care Self Efficacy Self Management Serum Severities Site Socioeconomic Status Stress Symptoms Systemic Lupus Erythematosus Testing Therapeutic Time Training Training Programs Translating Woman Work abstracting activation product biopsychosocial body-mind burden of illness complement C4d coping depressive symptoms design disability disability-adjusted life years emotion regulation follow-up health related quality of life immune activation immune function improved indexing innovation inventory of depressive symptomatology low socioeconomic status mindfulness novel novel strategies physical conditioning primary outcome psychologic psychological distress single episode major depressive disorder skills skills training skin disorder success therapy design

项目摘要

Abstract Systemic lupus erythematosus (SLE) is a chronic, multisystemic inflammatory disease that is frequently associated with significant psychological suffering. Building upon our team's strengths in lupus biomedical research and behavioral interventions, we propose to study a non-pharmacologic intervention to improve mental and physical health of patients with SLE and co-morbid depression. In this project, entitled, Reducing Depressive Symptoms in SLE, we will investigate the efficacy of an innovative non-pharmacologic intervention, Mind-Body Skills Training (MBST) for improving mental and physical health outcomes in SLE in a randomized controlled trial (RCT). MBST is a novel approach that combines cognitive-behavioral therapy methods, mind-body relaxation skills, and mindfulness components, each of which is beneficial for reducing pain and/or distress in other inflammatory conditions. We will assign 150 SLE patients with depressive disorder or subsyndromal depression to MBST or to a supportive counseling control condition. The primary specific aims of the project are to evaluate the effects of the 8-session MBST program on 1) mental health (depression) and 2) physical health (pain, fatigue, and health-related quality of life). Additionally we will explore the effects of the MBST intervention on 1) novel SLE biomarkers of inflammation and immune function: cell-bound complement activation products, developed at our site, 2) measures of SLE disease activity, and we will explore 3) potential treatment modifiers and mediators: baseline pain and socioeconomic status, and self-efficacy and perceived stress. We will evaluate health outcomes after the interventions and at 6- and 12-months follow-up. SLE is one of the most complex autoimmune diseases, with one of the highest rates of depression. The MBST intervention has strong potential for addressing the unique physical manifestations and mental suffering in this patient group, and may have broad impact on distressed patients with other debilitating chronic diseases.

抽象的全身性红斑狼疮（SLE）是一种慢性多体炎性疾病，经常是与重大的心理痛苦有关。基于我们团队在狼疮生物医学中的优势研究和行为干预措施，我们建议研究非药物干预以改善 SLE和合并抑郁症患者的心理和身体健康。在这个项目中，标题为SLE中的抑郁症状，我们将研究一个创新的非药物干预，思维技能培训（MBST），以改善心理和随机对照试验（RCT）中SLE的身体健康结果。 MBST是一种新颖的方法结合认知行为疗法的方法，思维自己的放松技巧和正念成分，每一种都有益于在其他炎症状况下减轻疼痛和/或困扰。我们将分配 150名患有抑郁症或亚抑制抑郁症的SLE患者到MBST或支持咨询控制条件。该项目的主要特定目的是评估8条MBST的影响 1）心理健康（抑郁）和2）身体健康（疼痛，疲劳和与健康相关的质量生活）。此外，我们将探讨MBST干预对1）新型SLE生物标志物的影响炎症和免疫功能：在我们站点开发的细胞结合补体激活产物2） SLE疾病活动的度量，我们将探索3）潜在的治疗修饰符和介体：基线疼痛和社会经济地位，自我效能和感知压力。我们将评估健康干预后的结果以及6个月和12个月的随访。 SLE是最复杂的自身免疫性疾病之一，是抑郁症最高的疾病之一。 MBST 干预具有解决独特的身体表现和精神痛苦的强大潜力患者组，可能对患有其他令人衰弱的慢性疾病的患者产生广泛的影响。