Musculoskeletal Structure and Strength

肌肉骨骼结构和力量

• 批准号: 8375252
• 负责人: MATTHEW J SILVA
• 金额: $ 22.44万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8375252
• 关键词: Adherence; Animal Model; Award; Biological Factors; Biology; Biomechanics; Bone Tissue; Canis familiaris; Collaborations; Data; Data Analyses; Degenerative polyarthritis; Densitometry; Diagnostic radiologic examination; Disease; Educational workshop; Ensure; Equipment; Fees; Fostering; Funding; Goals; Grant; Growth Factor; Human Resources; Image; Intervention; Measurement; Mechanics; Medicine; Metabolic; Modality; Morphology; Mus; Muscle; Muscular Dystrophies; Musculoskeletal; Musculoskeletal Diseases; Osteoporosis; Pain; Peripheral; Procedures; Productivity; Property; Protocols documentation; Quality Control; Research; Research Personnel; Resources; Roentgen Rays; Services; Simulate; Site; Structure; Surgical Injuries; Techniques; Tendon structure; Testing; Tissues; Training; Training Support; United States National Institutes of Health; Universities; Washington; X-Ray Computed Tomography; base; bone; bone strength; functional outcomes; genetic manipulation; in vivo; instrumentation; lost work time; member; musculoskeletal imaging; musculoskeletal injury; repaired; skeletal; treatment effect

Tissue structure and strength are the most relevant properties when assessing animal models related to musculoskeletal injury, disease and repair. Whether the treatment effects are created by genetic manipulation, metabolic challenge, simulated injury, surgical repair or other intervention, the net effects must be judged based on whether they have resulted in more or less tissue, whether that tissue has normal morphology, and whether the tissue or skeletal structure has increased or decreased mechanical properties. We have the necessary equipment and the demonstrated user expertise to assess the structural and mechanical properties of a range of musculoskeletal tissue and structures derived from animal models. There have been productive collaborations between investigators in the Research Base and the personnel of this Core, but these have been limited in number by the lack of a mechanism to support the acquisition and analysis of data by expert users and the training of non-expert users. The objective of this Musculoskeletal Structure and Strength Core (Core B) is to provide a mechanism to increase access to existing resources for x-ray based densitometry and imaging, and mechanical testing, and to thereby enable new interactions and enhance existing interactions between musculoskeletal researchers at Washington University. We will maintain protocols and equipment to promote quality control, provide technical support and training, and perform the following services on musculoskeletal structures and tissues from animal models (mouse to canine) generated by investigators in the Core Center Research Base. Aim 1: X-ray based imaging; available modalities include radiography, dual-energy x-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and micro-computed tomography (microCT). Each of these is available for ex vivo or in vivo imaging. Aim 2: Mechanical testing; available modalities include whole-bone bending and compression, trabecular indentation, tensile testing of demineralized bone, tendon and tendon-bone insertion site tensile testing; muscle force measurement. By offering these Core services we will increase research productivity of established musculoskeletal investigators on our campus and facilitate non-musculoskeletal investigators wishing to bring new perspectives to studies in musculoskeletal biology and medicine.

在评估与 肌肉骨骼损伤，疾病和修复。是否通过遗传产生治疗效果 操纵，代谢挑战，模拟伤害，手术修复或其他干预，净效应必须 根据它们是否导致或多或少的组织来判断，该组织是否正常 形态以及组织或骨骼结构是否增加或降低了机械性能。 我们拥有必要的设备和所展示的用户专业知识，以评估结构和 一系列肌肉骨骼组织和源自动物模型的结构的机械性能。 研究基础的调查员与 这个核心，但是由于缺乏支持收购和 专家用户和非专家用户的培训分析数据。该肌肉骨骼的目的 结构和力量核心（核心B）是提供一种机制，以增加对现有资源的访问 基于X射线的光密度法和成像以及机械测试，从而实现新的相互作用和 加强华盛顿大学肌肉骨骼研究人员之间的现有相互作用。我们将 维护协议和设备，以促进质量控制，提供技术支持和培训以及 在动物模型（小鼠到小鼠的肌肉骨骼结构和组织）上执行以下服务 由核心中心研究基础的调查员生成的犬）。目标1：基于X射线的成像； 可用的方式包括射线照相，双能X射线吸收法（DXA），外围定量 计算机断层扫描（PQCT）和微型层析成像（Microct）。这些都可以用于EX 体内或体内成像。目标2：机械测试；可用方式包括全骨弯曲和 压缩，小梁压痕，脱矿质骨骼，肌腱和肌腱插入的拉伸测试 现场拉伸测试；肌肉力量测量。通过提供这些核心服务，我们将增加研究 我们校园内已建立的肌肉骨骼研究人员的生产力，并促进非肌肉骨骼 希望为肌肉骨骼生物学和医学研究带来新观点的研究人员。