Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups

将精神病前兆的调查范围扩大到不同文化群体

基本信息

批准号：
8210870
负责人：
Huijun Li
金额：
$ 12.98万
依托单位：
FLORIDA AGRICULTURAL AND MECHANICAL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-06 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8210870
关键词：
Adolescent Affect American Applications Grants Area Asians Australia Biological Blood specimen Boston Brain Brain Diseases Brain Injuries Canada Characteristics China Chinese People Chronic Clinical Clinical assessments Complement Country Data Development Diabetes Mellitus Diagnostic Diagnostics Research Early identification Early treatment Electroencephalography England Environment Ethnic group Europe Event-Related Potentials Foundations Funding Future Gender Genetic Germany Goals Grant Guidelines Heart Diseases Hong Kong Impairment Income Individual Intervention Interview Investigation Israel Japan Language Lead Longevity Longitudinal Studies Low income Measures Medical center Mental Health Morbidity - disease rate Movement Neurocognitive North America Patients Phase Phenotype Population Population Study Prevention Prevention strategy Preventive Preventive Intervention Procedures Process Process Measure Program Development Psychiatry Psychotic Disorders Public Health Publications Reporting Research Research Personnel Research Training Resources Risk Risk Factors Risk Management Role Schizophrenia Singapore Staging Stigmata Structure Switzerland Symptoms Syndrome System Techniques Time Training Training Support Translating United States World Health Organization Youth biopsychosocial design functional decline high risk improved information processing instrument medical schools mental health center mental state neuropsychological novel strategies programs psychosocial quality assurance racial and ethnic skills skills training social stigma socioeconomics therapy development tool treatment trial young adult

项目摘要

The identification of people who are at risk of developing psychosis is central to the development of early intervention and prevention strategies for schizophrenia. There is a world-wide movement in the study of populations at the prodromal stage led by researchers in the United States, Australia, England, Canada, Germany, and Switzerland. It is important to understand the biopsychosocial processes that occur during the clinical high risk (CHR) phase. The North American Prodrome Longitudinal Study (NAPLS) has identified key clinical characteristics and predictors of CHR youth using a comprehensive assessment package encompassing psychosocial, biological, neuropsychological, and genetic components. This is critical because it informs development of early interventions for prevention of brain damage. However, the NAPLS study is limited to the North American subjects. The purpose of this project is to broaden the existing prodrome to psychosis study to populations in a different cultural and genetic pool to examine the important cultural differences in the manifestations of the symptoms and the predictors of the illness. The overall goal of this application is to design and initiate a sustainable CHR to psychosis longitudinal program of research in a low-middle income country. Specifically, we attempt to: 1. Assess potential research needs of the Shanghai Mental Health Center [SMHC], a World Health Organization designated researcher center for mental health, and 2. Help develop a program of research on the progression of schizophrenia from prodrome to psychosis. The preliminary study contains four major components: a) clinical assessment of prodromal subjects. For this aim, the Structured Interview for Prodromal Syndromes and Scale of Prodromal Symptoms (SIPS/SOPS) will be translated into the language of the subjects and subsequently validated; b) neurocognitive assessment with the MATRICS battery, c) stigma, and d) electrophysiological assessment using event related potentials. In addition, blood samples will be collected and stored for future analyses. Gender effects will be examined across the above aims. The study goals are consistent with the guidelines of the FOA Brain Disorders in the Developing World: Research Across the Lifespan (R21, PAR-11-031).

识别有患精神病风险的人对于制定精神分裂症早期干预和预防策略至关重要。由美国、澳大利亚、英国、加拿大、德国和瑞士的研究人员领导的世界范围内的前驱期人群研究运动正在兴起。了解临床高风险 (CHR) 阶段发生的生物心理社会过程非常重要。北美前驱症状纵向研究 (NAPLS) 使用涵盖社会心理、生物、神经心理学和遗传成分的综合评估包，确定了青少年 CHR 的关键临床特征和预测因素。这很重要，因为它为预防脑损伤的早期干预措施的开发提供了信息。然而，NAPLS 研究仅限于北美受试者。该项目的目的是将现有的精神病前驱症状研究范围扩大到不同文化和基因库的人群，以检查症状表现和疾病预测因素中的重要文化差异。该应用程序的总体目标是在中低收入国家设计并启动可持续的 CHR 精神病纵向研究计划。具体来说，我们试图： 1. 评估上海精神卫生中心 [SMHC]（世界卫生组织指定的心理健康研究中心）的潜在研究需求，以及 2. 帮助制定一项关于精神分裂症从前驱症状到症状发展的研究计划。精神病。初步研究包含四个主要部分：a）前驱受试者的临床评估。为此，前驱综合征结构化访谈和前驱症状量表 (SIPS/SOPS) 将被翻译成受试者的语言并随后进行验证； b) 使用 MATRICS 电池进行神经认知评估，c) 耻辱感，以及 d) 使用事件相关电位进行电生理学评估。此外，还将收集并储存血液样本以供将来分析。将在上述目标中审查性别影响。研究目标与《发展中国家 FOA 脑部疾病：跨生命周期的研究》（R21，PAR-11-031）的指南一致。