A Psychobiological Follow-up Study of Transition from Prodrome to Early Psychosis

从前驱症状到早期精神病转变的心理生物学随访研究

• 批准号: 10011832
• 负责人: Huijun Li
• 金额: $ 58.91万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10011832
• 关键词: Address; Adolescent and Young Adult; Age; Age of Onset; American; Asia; Asians; Australia; Biological; Biological Assay; Biological Markers; Biological Process; Brain; China; Clinical; Clinical Trials; Cognitive; Collaborations; Community Health Education; Data; Data Collection; Diffuse; Diffusion Magnetic Resonance Imaging; Early Intervention; Europe; Event-Related Potentials; Evolution; Family member; Florida; Follow-Up Studies; Foundations; Functional Magnetic Resonance Imaging; Goals; Grant; Hospitals; Individual; Institutes; Intervention; Joints; Literature; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Massachusetts; Measures; Medial; Memory; Mental Health; Movement; Myelin; National Institute of Mental Health; Nature; Neurocognition; Neurocognitive; North America; Outcome; Parahippocampal Gyrus; Participant; Patients; Pharmaceutical Preparations; Phase; Prefrontal Cortex; Preventive Intervention; Process; Psychotic Disorders; Research; Research Personnel; Research Training; Rest; Risk; Risk Factors; Role; Schizophrenia; Singapore; Site; Social Functioning; Solid; Structure; Surveys; Symptoms; Taiwan; Technology; Testing; Time; Training; Training and Education; United States National Institutes of Health; Universities; Verbal Learning; Water; Work; World Health Organization; base; biopsychosocial; clinical biomarkers; disability; follow up assessment; follow-up; gray matter; high risk; high risk population; improved; low and middle-income countries; medical schools; mental health center; neocortical; nervous system disorder; neuroinflammation; novel; predictive marker; preference; processing speed; programs; progression marker; psychobiologic; psychosocial; response; social; social stigma; virtual; white matter

7. Project Summary/Abstract: There is a worldwide movement in the early intervention for adolescents and young adults appearing to develop early signs of psychosis or described as at clinical high risk (CHR) for psychosis, led mainly by researchers in Australia, Europe, and North America. Within the Asian Network for Early Psychosis, Taiwan and Singapore have started to address the CHR population. To our knowledge, we are the first research group carrying out CHR studies in a low-middle income country in Asia. Since 2012, supported by NIMH/Fogarty 1R21MH093294-01A1 and an NIMH R01 MH101052-01, we have worked closely with the Shanghai Mental Health Center (SMHC), to develop a CHR research program in Shanghai, China. The completed R21 and on-going R01 projects aim at identification of the risk factors for CHR conversion over approximately one year. In our current proposal, in response to NIH FOA PAR-14-332, Global Brain and Nervous System Disorders Research across the Lifespan (R01), we will continue to enhance research capacity building at SMHC, and collaboratively carry out an extensive follow-up study of clinical outcomes such as conversion to psychosis and level of disability, and we will evaluate the evolution of biomarkers such as event related potentials, resting state functional magnetic resonance imaging (MRI), white matter as assessed by diffusion tensor imaging MRI, and neurocognition. We will follow-up 300 well characterized CHR and Healthy Control (HC) participants between the ages of 15-45 for two more follow-up assessments. The longitudinal nature of the project is novel in China and worldwide as this will be the first study to comprehensively examine biopsychosocial parameters predictive of psychosis conversion and illness progression for up to 6 years, including two new follow-ups of the biomarkers (4 assessments including baseline). Moreover, unlike many studies in the West, virtually 100% of the participants are psychotropically naïve when they enter the study, and the assessments are done at one site (SMHC), reducing confounds associated with medications and multiple sites. Our goal is to work collaboratively with researchers at the SMHC to establish a sustainable CHR longitudinal program of research in China and to lay a solid foundation for CHR early intervention.This project aims to: 1). Develop predictors for conversion to psychosis, 2). Investigate clinical and biomarker progression in CHR, 3). Demonstrate an association between clinical features, biological measures and disability in CHR, and 4). Explore the feasibility of early intervention with CHR subjects. Capacity building and research training will be conducted during and beyond the proposed project to facilitate sustainable research at SMHC.

7。项目摘要/摘要： 对于青少年和年轻人来说 出现精神病的早期迹象或被描述为临床高风险（CHR）的精神病，主要由 澳大利亚，欧洲和北美的研究人员。在亚洲早期精神病网络中，台湾 新加坡已经开始解决CHR人口。据我们所知，我们是第一个研究小组 在亚洲一个低中型收入国家进行CHR研究。自2012年以来，由NIMH/Fogarty支持 1R21MH093294-01A1和NIMH R01 MH101052-01，我们已经与上海的心理健康密切合作 中心（SMHC），在中国上海制定CHR研究计划。完整的R21和正在进行的 R01项目旨在识别大约一年的CHR转化风险因素。在我们的 当前的提案，应对NIH FOA PAR-14-332，全球大脑和神经系统疾病研究 在整个寿命（R01）中，我们将继续增强SMHC的研究能力建设，并 协作对临床结果的广泛后续研究，例如转化为精神病和 残疾水平，我们将评估生物标志物（例如事件相关电位）的演变，休息 状态功能磁共振成像（MRI），通过扩散张量成像MRI评估的白质， 和神经认知。我们将跟进300个特征良好的CHR和健康对照（HC）参与者 在15-45岁之间进行两次随访评估。该项目的纵向性质是新颖的 在中国和世界范围内，这将是第一个全面研究生物心理社会参数的研究 预测精神病转化和疾病进展长达6年，包括两次新的随访 生物标志物（包括基线在内的4个评估）。此外，与西方许多研究不同，几乎是100％ 参与者进入研究时是精神上的幼稚，评估是一个人进行的 站点（SMHC），减少与药物和多个部位相关的混杂。我们的目标是工作 与SMHC的研究人员合作，建立可持续的CHR纵向研究计划 在中国，并为CHR早期干预奠定了坚实的基础。该项目的目的是：1）。开发预测指标 转换为精神病，2）。研究CHR，3）中的临床和生物标志物进展。展示一个 CHR中的临床特征，生物学测量和残疾与4）之间的关联。探索可行性 早期干预CHR受试者。能力建设和研究培训将在和 除了促进SMHC可持续研究的拟议项目之外。