Cognitive and Affective Neuroscience of Atypical Empathy in Conduct Disorder

品行障碍中非典型同理心的认知和情感神经科学

基本信息

批准号：
8243471
负责人：
JEAN DECETY
金额：
$ 36.29万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8243471
关键词：
11 year old Address Adolescence Adolescent Adult Affect Affective Aggressive behavior Amygdaloid structure Anatomy Anisotropy Anterior Antisocial Personality Disorder Area Arousal Attention Autonomic nervous system Awareness Basic Science Behavior Brain Cessation of life Chicago Child Childhood Commit Complex Conduct Disorder Craniocerebral Trauma Crime Data Deceleration Deformity Detection Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Distress Dorsal Emotional Emotions Empathy Environment Exhibits Female Fiber Foundations Functional Magnetic Resonance Imaging Future Goals Heart Rate Home environment Homicide Imprisonment Individual Differences Informal Social Control Injury Insula of Reil Lateral Laws Lead Learning Life Style Longevity Magnetic Resonance Imaging Measurement Measures Medial Mental Depression Mental Health Mental disorders Mind Modeling Molecular Motor National Institute of Mental Health Nature Neurobiology Pain Patient Self-Report Pattern Perception Persons Physical aggression Physiology Play Population Prevention Process Property Psychophysiology Public Health Reaction Regulation Research Research Personnel Resources Rest Rewards Risk Role Running Sampling Sensory Series Signal Transduction Social Interaction Somatosensory Cortex Staging Stimulus Structure Substance abuse problem Suicide Symptoms System Testing Theft Translating Translational Research Universities Ventral Striatum Violence Youth affective neuroscience anti social association cortex base behavior measurement brain behavior bullying cingulate cortex cognitive control cognitive neuroscience design emerging adult emotion regulation executive function experience genetic analysis gray matter heart rate variability hemodynamics high risk innovation interest male meetings midbrain central gray substance morphometry neural circuit neuroimaging novel strategies pleasure psychologic relating to nervous system response sex social stimulus processing theories translational study visual stimulus white matter

项目摘要

Project Summary The proposed study will comparatively evaluate three hypotheses regarding biopsychological mechanisms underpinning atypical empathy in conduct disorder (CD). Significance: Antisocial behavior across the lifespan creates an enormous public health burden. Despite the indisputable importance of social factors, much remains to be learned about neurobiological factors involved in childhood CD. Empathic concern for others has been hypothesized to play a key role in inhibiting aggression and other forms of antisocial behavior and deficits in empathy lead to profound disturbances in social interaction. Therefore, studies of the role of atypical empathic concern in childhood CD are of great importance. Innovation: The proposed study would be the first neurobiological study of atypical empathy in pre-adolescent children with CD using functional magnetic resonance imaging. It will provide the empirical basis for a much-needed integrative biopsychological model of the basic brain-behavior processes involved in dysfunctional empathy in CD. Multiple levels of scientific analysis are fundamentally important when addressing complex phenomena such as CD. Too often, the assessment of empathy in both healthy and psychiatric populations has relied solely on self-report measures that provide only one kind of information. Approach: To achieve our scientific aims we will obtain from male and female 9-11 year old children who meet diagnostic criteria for CD (N = 60) and a group of non-CD control children (N = 60) a number of neurobiological and behavioral measures of responses to viewing others in pain. These measures include: (a) structural brain anatomy and functional connectivity (b) neuro-hemodynamic responses to visual stimuli that typically evoke empathic concern, (c) subjective ratings of the affect elicited by viewing others in pain, (d) behavioral measures of approach tendencies to stimuli depicting pain in others, and (e) measures of autonomic nervous system activity. We hypothesize that when viewing others in pain, children with CD will exhibit greater neuro-hemodynamic response in areas of the pain matrix involved in both the sensory-discriminative and affective aspects of the first-hand experience of pain. The behavioral measures will indicate that children with CD experience a more positive affective response to seeing others in pain than comparison children. Furthermore, children with CD will exhibit both less anatomical connection and functional connectivity between the PFC and the amygdala, which would be consistent with diminished self-regulation of emotional aspects of empathic concern for others in distress. Environment and Investigators: Our experienced team of investigators and consultants includes experts on CD, functional neuroimaging and cognitive neuroscience, especially in the area of empathy, and psychophysiological measurement. The University of Chicago provides a strong environment and resources for this project.

项目摘要拟议的研究将相对评估有关生物心理学机制的三个假设行为障碍（CD）的非典型同理心基础。意义：整个生命周期的反社会行为产生巨大的公共卫生负担。尽管社会因素的重要性无可争议，但关于儿童cd中涉及的神经生物学因素还有待了解。对他人的移情关注假设在抑制侵略和其他形式的反社会行为和缺陷方面发挥关键作用在同理心中导致社会互动的深刻干扰。因此，研究非典型的作用儿童CD中的移情关注至关重要。创新：拟议的研究将是第一个在青春期前CD儿童中使用功能磁性的非典型同理心的神经生物学研究共振成像。它将为急需的综合生物心理学模型提供经验基础 CD中涉及功能失调的同理心的基本脑行为过程。多层次的科学当解决复杂现象（例如CD）时，分析至关重要。经常，在健康和精神病种群中的同理心评估仅依赖于自我报告措施仅提供一种信息。方法：为了实现我们将从男性获得的科学目标符合CD诊断标准（n = 60）和一组非CD对照的女性9-11岁的女性9-11岁的孩子儿童（n = 60）对观察他人疼痛的反应的许多神经生物学和行为度量。这些措施包括：（a）结构性大脑解剖结构和功能连通性（b）神经 - 耳动力学对通常引起移情问题的视觉刺激的反应，（c）对影响的主观评级。在痛苦中查看他人，（d）刺激描述他人疼痛的方法趋势的行为度量，（e）自主神经系统活动的度量。我们假设在痛苦中观看他人时，孩子与CD一起将在涉及两者的疼痛矩阵的区域中表现出更大疼痛的第一手经验的感觉歧视和情感方面。行为措施将表明患有CD的儿童经历了对看到他人痛苦的更积极的情感反应比较儿童。此外，患有CD的儿童将表现出较少的解剖联系和功能性 PFC和杏仁核之间的连接性，这与自我调节的减少一致遇难者的情感方面的情感方面。环境与研究人员：我们的经验丰富的研究人员和顾问团队包括CD的专家，功能性神经影像学和认知神经科学，尤其是在同理心和心理生理测量领域。这芝加哥大学为该项目提供了强大的环境和资源。