Cognitive and Affective Neuroscience of Atypical Empathy in Conduct Disorder

品行障碍中非典型同理心的认知和情感神经科学

• 批准号: 7725804
• 负责人: JEAN DECETY
• 金额: $ 36.78万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725804
• 关键词: 11 year old; Address; Adolescence; Adolescent; Adult; Affect; Affective; Aggressive behavior; Amygdaloid structure; Anatomy; Anisotropy; Anterior; Antisocial Personality Disorder; Area; Arousal; Attention; Autonomic nervous system; Awareness; Basic Science; Behavior; Bone callus; Brain; Cessation of life; Chicago; Child; Childhood; Cognitive; Commit; Complex; Conduct Disorder; Craniocerebral Trauma; Crime; Data; Deceleration; Deformity; Detection; Diagnostic; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Distress; Dorsal; Emotional; Emotions; Empathy; Environment; Exhibits; Female; Fiber; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Hand; Heart Rate; Home environment; Homicide; Imprisonment; Individual Differences; Informal Social Control; Injury; Insula of Reil; Lateral; Laws; Lead; Learning; Life Style; Longevity; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mental Health; Mental disorders; Mind; Modeling; Molecular; Motor; National Institute of Mental Health; Nature; Neurobiology; Pain; Patient Self-Report; Pattern; Perception; Persons; Physical aggression; Physiology; Play; Population; Prevention; Process; Property; Psychophysiology; Public Health; Reaction; Regulation; Research; Research Personnel; Resources; Rest; Rewards; Risk; Role; Running; Sampling; Sensory; Series; Signal Transduction; Social Interaction; Somatosensory Cortex; Staging; Stimulus; Structure; Substance abuse problem; Suicide; Symptoms; System; Testing; Theft; Translating; Translational Research; Universities; Ventral Striatum; Violence; Youth; affective neuroscience; anti social; association cortex; base; behavior measurement; brain behavior; bullying; cingulate cortex; cognitive control; cognitive neuroscience; depression; design; disorder control; emerging adult; emotion regulation; executive function; experience; genetic analysis; gray matter; heart rate variability; hemodynamics; high risk; innovation; interest; male; meetings; midbrain central gray substance; morphometry; neural circuit; neuroimaging; novel strategies; pleasure; psychologic; public health relevance; relating to nervous system; response; sex; social; stimulus processing; theories; translational study; visual stimulus; white matter; 11 year old; Address; Adolescence; Adolescent; Adult; Affect; Affective; Aggressive behavior; Amygdaloid structure; Anatomy; Anisotropy; Anterior; Antisocial Personality Disorder; Area; Arousal; Attention; Autonomic nervous system; Awareness; Basic Science; Behavior; Bone callus; Brain; Cessation of life; Chicago; Child; Childhood; Cognitive; Commit; Complex; Conduct Disorder; Craniocerebral Trauma; Crime; Data; Deceleration; Deformity; Detection; Diagnostic; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Distress; Dorsal; Emotional; Emotions; Empathy; Environment; Exhibits; Female; Fiber; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Hand; Heart Rate; Home environment; Homicide; Imprisonment; Individual Differences; Informal Social Control; Injury; Insula of Reil; Lateral; Laws; Lead; Learning; Life Style; Longevity; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mental Health; Mental disorders; Mind; Modeling; Molecular; Motor; National Institute of Mental Health; Nature; Neurobiology; Pain; Patient Self-Report; Pattern; Perception; Persons; Physical aggression; Physiology; Play; Population; Prevention; Process; Property; Psychophysiology; Public Health; Reaction; Regulation; Research; Research Personnel; Resources; Rest; Rewards; Risk; Role; Running; Sampling; Sensory; Series; Signal Transduction; Social Interaction; Somatosensory Cortex; Staging; Stimulus; Structure; Substance abuse problem; Suicide; Symptoms; System; Testing; Theft; Translating; Translational Research; Universities; Ventral Striatum; Violence; Youth; affective neuroscience; anti social; association cortex; base; behavior measurement; brain behavior; bullying; cingulate cortex; cognitive control; cognitive neuroscience; depression; design; disorder control; emerging adult; emotion regulation; executive function; experience; genetic analysis; gray matter; heart rate variability; hemodynamics; high risk; innovation; interest; male; meetings; midbrain central gray substance; morphometry; neural circuit; neuroimaging; novel strategies; pleasure; psychologic; public health relevance; relating to nervous system; response; sex; social; stimulus processing; theories; translational study; visual stimulus; white matter

DESCRIPTION (provided by applicant): The proposed study will comparatively evaluate three hypotheses regarding biopsychological mechanisms underpinning atypical empathy in conduct disorder (CD). Significance: Antisocial behavior across the lifespan creates an enormous public health burden. Despite the indisputable importance of social factors, much remains to be learned about neurobiological factors involved in childhood CD. Empathic concern for others has been hypothesized to play a key role in inhibiting aggression and other forms of antisocial behavior and deficits in empathy lead to profound disturbances in social interaction. Therefore, studies of the role of atypical empathic concern in childhood CD are of great importance. Innovation: The proposed study would be the first neurobiological study of atypical empathy in pre-adolescent children with CD using functional magnetic resonance imaging. It will provide the empirical basis for a much-needed integrative biopsychological model of the basic brain-behavior processes involved in dysfunctional empathy in CD. Multiple levels of scientific analysis are fundamentally important when addressing complex phenomena such as CD. Too often, the assessment of empathy in both healthy and psychiatric populations has relied solely on self-report measures that provide only one kind of information. Approach: To achieve our scientific aims we will obtain from male and female 9-11 year old children who meet diagnostic criteria for CD (N = 60) and a group of non-CD control children (N = 60) a number of neurobiological and behavioral measures of responses to viewing others in pain. These measures include: (a) structural brain anatomy and functional connectivity (b) neuro-hemodynamic responses to visual stimuli that typically evoke empathic concern, (c) subjective ratings of the affect elicited by viewing others in pain, (d) behavioral measures of approach tendencies to stimuli depicting pain in others, and (e) measures of autonomic nervous system activity. We hypothesize that when viewing others in pain, children with CD will exhibit greater neuro-hemodynamic response in areas of the pain matrix involved in both the sensory-discriminative and affective aspects of the first-hand experience of pain. The behavioral measures will indicate that children with CD experience a more positive affective response to seeing others in pain than comparison children. Furthermore, children with CD will exhibit both less anatomical connection and functional connectivity between the PFC and the amygdala, which would be consistent with diminished self-regulation of emotional aspects of empathic concern for others in distress. Environment and Investigators: Our experienced team of investigators and consultants includes experts on CD, functional neuroimaging and cognitive neuroscience, especially in the area of empathy, and psychophysiological measurement. The University of Chicago provides a strong environment and resources for this project. PUBLIC HEALTH RELEVANCE: Because most crime is committed by juveniles, antisocial behavior in youth creates an enormous public health burden. Antisocial behavior not only harms victims in physical and psychological ways, but antisocial youth are at high risk for incarceration, injury and death from violence, substance abuse, and suicide. The proposed translational study will lead to an integrative understanding of basic brain-behavior processes involved in dysfunctional empathic concern in children with conduct disorder and suggest new approaches to treatment and prevention.

描述（由申请人提供）：拟议的研究将比较评估有关行为障碍非典型同理心（CD）的生物心理学机制的三个假设。意义：整个生命周期的反社会行为造成了巨大的公共卫生负担。尽管社会因素的重要性无可争议，但有关儿童CD中涉及的神经生物学因素仍有许多待了解。假设对他人的同理心关心在抑制侵略和其他形式的反社会行为和移情中的缺陷方面发挥关键作用，从而导致社会互动的深刻干扰。因此，对非典型移情关注在儿童时期CD中的作用的研究非常重要。创新：拟议的研究将是使用功能性磁共振成像的青春期前儿童中非典型同理心的首次神经生物学研究。它将为CD功能失调的同理心涉及的基本脑行为过程的基本脑行为过程的急需的综合生物心理学模型提供经验基础。当解决复杂现象（例如CD）时，多个级别的科学分析至关重要。通常，在健康和精神病学人群中对同理心的评估仅依赖于仅提供一种信息的自我报告措施。方法：为了实现我们的科学目标，我们将从符合CD诊断标准（n = 60）和一组非CD对照儿童（n = 60）的男性和女性9-11岁的孩子那里获得，许多神经生物学和行为措施是对观察痛苦中其他人的反应的措施。这些措施包括：（a）结构性大脑解剖结构和功能连通性（b）对视觉刺激的神经 - 移动动力的反应，通常引起移情关注，（c）通过在疼痛中查看他人的主观评分，（d）（d）刺激刺激对他人疼痛的行为趋势，以使其疼痛刺激疼痛，以及（e）自动及其自动及其自动性系统性的影响。我们假设，在疼痛中观看其他人时，患有CD的儿童将在疼痛的感觉歧视和情感方面涉及的疼痛矩阵的区域中表现出更大的神经性血流动力学反应。行为措施将表明，患有CD的儿童经历了比较儿童的痛苦中其他人的情感反应。此外，患有CD的儿童将在PFC和Amygdala之间表现出较少的解剖联系和功能连接，这与对遇难者的其他人的情感方面的自我调节减少是一致的。环境和研究人员：我们经验丰富的研究人员和顾问团队包括CD的专家，功能性神经影像学和认知神经科学，尤其是在移情领域以及心理生理测量领域。芝加哥大学为该项目提供了强大的环境和资源。公共卫生相关性：由于大多数犯罪是由少年犯下的，因此青年人的反社会行为会造成巨大的公共卫生负担。反社会行为不仅会以身体和心理方式损害受害者，而且反社会青年因暴力，滥用药物和自杀而受到监禁，伤害和死亡的高风险。拟议的翻译研究将导致对行为障碍儿童功能失调的移情问题涉及的基本脑行为过程的综合理解，并提出新的治疗和预防方法。