Cancer Epidemiology

癌症流行病学

基本信息

批准号：
8369386
负责人：
MICHELE CARBONE
金额：
$ 1万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8369386
关键词：
Achievement Address Appointment Area Bacterial Infections Behavioral Bioinformatics Biological Biological Assay Biology Biometry Breast Cancer Burden Cancer Center Cancer Center Support Grant Cancer Etiology Cancer Family Clinical Investigator Clinical Research Collaborations Colon Colorectal Cancer Complex Copy Number Polymorphism Detection Development Diet Diet and Nutrition Disease Early Diagnosis Endometrium Environmental Exposure Environmental Risk Factor Epidemiologic Studies Epidemiologist Epidemiology Epigenetic Process Ethnic Origin Ethnic group Evaluation Exhibits Faculty Family-Based Registry Focus Groups Fostering Funding Future Gene Expression Gene Mutation Genes Genetic Genetic Polymorphism Genetic Predisposition to Disease Genetic Variation Goals Government Agencies Grant Growth and Development function Hawaii Hormones Human Papillomavirus Incidence Infection Infectious Agent Interdisciplinary Study Intervention Intervention Studies Investigation Joints Journals Knowledge Laboratories Leadership Life Life Style Longevity Lung Macronutrients Nutrition Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Measures Methods Micronutrients Molecular Molecular Biology Molecular Epidemiology Molecular Genetics NCI Center for Cancer Research Nutrient Nutritional Obesity Organ Ovary Paper Pathologist Patients Peer Review Persons Play Population Population Heterogeneity Predisposition Prevention Prevention strategy Prostate Publications Publishing Race Recruitment Activity Regulation Research Research Activity Research Personnel Research Project Grants Residual state Resources Retirement Risk Risk Factors Role Single Nucleotide Polymorphism Site Smoking Specificity Tissues Training Translating Translational Research United States National Institutes of Health Universities Variant Viral Cancer Virus Diseases anticancer research cancer epidemiology cancer genetics cancer health disparity cancer prevention cancer risk cancer therapy carcinogenesis clinical application cohort dietary constituent ethnic difference experience gene environment interaction genetic risk factor improved interdisciplinary collaboration interest lifestyle factors malignant mouth neoplasm member mortality nutrition nutritional epidemiology prognostic indicator programs racial and ethnic racial/ethnic difference repository scientific organization treatment response tumor progression tumor registry tumorigenesis

Achievement Address Appointment Area Bacterial Infections Behavioral Bioinformatics Biological Biological Assay Biology Biometry Breast Cancer Burden Cancer Center Cancer Center Support Grant Cancer Etiology Cancer Family Clinical Investigator Clinical Research Collaborations Colon Colorectal Cancer Complex Copy Number Polymorphism Detection Development Diet Diet and Nutrition Disease Early Diagnosis Endometrium Environmental Exposure Environmental Risk Factor Epidemiologic Studies Epidemiologist Epidemiology Epigenetic Process Ethnic Origin Ethnic group Evaluation Exhibits Faculty Family-Based Registry Focus Groups Fostering Funding Future Gene Expression Gene Mutation Genes Genetic Genetic Polymorphism Genetic Predisposition to Disease Genetic Variation Goals Government Agencies Grant Growth and Development function Hawaii Hormones Human Papillomavirus Incidence Infection Infectious Agent Interdisciplinary Study Intervention Intervention Studies Investigation Joints Journals Knowledge Laboratories Leadership Life Life Style Longevity Lung Macronutrients Nutrition Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Measures Methods Micronutrients Molecular Molecular Biology Molecular Epidemiology Molecular Genetics NCI Center for Cancer Research Nutrient Nutritional Obesity Organ Ovary Paper Pathologist Patients Peer Review Persons Play Population Population Heterogeneity Predisposition Prevention Prevention strategy Prostate Publications Publishing Race Recruitment Activity Regulation Research Research Activity Research Personnel Research Project Grants Residual state Resources Retirement Risk Risk Factors Role Single Nucleotide Polymorphism Site Smoking Specificity Tissues Training Translating Translational Research United States National Institutes of Health Universities Variant Viral Cancer Virus Diseases anticancer research cancer epidemiology cancer genetics cancer health disparity cancer prevention cancer risk cancer therapy carcinogenesis clinical application cohort dietary constituent ethnic difference experience gene environment interaction genetic risk factor improved interdisciplinary collaboration interest lifestyle factors malignant mouth neoplasm member mortality nutrition nutritional epidemiology prognostic indicator programs racial and ethnic racial/ethnic difference repository scientific organization treatment response tumor progression tumor registry tumorigenesis

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项目摘要

The Epidemiology (EPI) Program is one of the founding programs at the University of Hawai'i Cancer Center (UHCC), and currently composed of 11 full members and 2 associate members, who are molecular, genetic and nutritional epidemiologists, biostatistician and bioinformatician with primary appointments at UHCC. The EPI Program has made significant progress in recent years, and the EPI faculty have contributed substantially to the Cancer Center's research. During the current funding cycle, the Program members have published more than 400 cancer-related research articles in peer-reviewed journals, rising from 214 in the previous funding cycle, and obtained $20.5 million research grants from NIH increasing from $16.1 million in the previous grant cycle. Recently, the EPI Program has recruited a new program leader who is a molecular epidemiologist with 30 years of cancer research experience, and he brings to the Program more translational research and interdisciplinary collaboration for further development and growth of the Program. The goal of the EPI Program is to identify environmental, lifestyle and genetic factors that are attributable to the risk of cancer development and progression in populations with diverse race and ethnicity, and use the knowledge to develop strategies and programs to reduce cancer risk and prolong patient survival. To achieve this goal, members of the EPI Program focus on 3 areas of research emphasis which are under the overarching theme of racial/ethnic diversity. The 3 research areas are 1) genetic susceptibility, 2) nutrition and lifestyle and 3) infectious agents. Under each area of research emphasis, the Program has multiple current and future aims. To achieve these aims, the Program has established and maintained valuable resources which include Hawaii Tumor Registry, Multiethnic Cohort, HPV Cohorts, Colorectal Cancer Family Registry, and Residual Tissue Repository. Using these unique resources, the Program members have completed a large number of research projects which include many molecular and genetic epidemiological studies that address the role of single nucleotide polymorphisms in genetic susceptibility to cancer. Numerous genetic polymorphisms have been investigated for their association with the risk of several major cancers, including the breast, prostate, colon, lung, endometrium and ovary. These studies have contributed significantly to our understanding of cancer genetics and susceptibility. EPI focus in this area will continue to expand to include more genetic features, their interaction with environmental and lifestyle factors and their involvement In tumor progression and treatment response. The EPI Program has also accomplished significantly in the research area of nutrition and lifestyle in cancer. The multiethnic cohort was established initially focusing mainly on diet and nutrition. Numerous studies have been conducted on the cohort to understand diet and nutrition in cancer in different ethnic groups. Gene-nutrition interaction and lifestyle-related epigenetic changes will be new focuses in this area. HPV research by the EPI faculty also generates valuable information on viral infection and cancer risk. Future research in this area will focus on more infectious agents and their interaction with epigenetic regulation in cancer etiology, detection and prevention. The EPI Program has significant interaction with other programs at the Cancer Center through focus groups, research collaboration, faculty training, seminars and other joint activities. The interactions foster strong collaborations that facilitate interdisciplinary and translational research at the Cancer Center to achieve the goal of reducing the cancer burden among people in Hawai'i.

流行病学（EPI）计划是夏威夷大学癌症中心（UHCC）的创始计划之一，目前由11名正式成员和2名副成员组成，他们是分子，遗传和营养流行病学家，生物统计学家和生物信息学家，并在UHCC中进行了初级任命。 EPI计划近年来取得了重大进展，EPI教师为癌症中心的研究做出了重大贡献。在当前的资金周期中，该计划成员在同行评审期刊上发表了400多个与癌症相关的研究文章，从上一个融资周期的214个上升，并从NIH获得了2050万美元的研究赠款，从上一个赠款周期中的1610万美元增加了。最近，EPI计划招募了一名新的计划领导者，他是一名具有30年癌症研究经验的分子流行病学家，他为该计划带来了更多的转化研究和跨学科合作，以进一步发展和发展该计划。 EPI计划的目的是确定归因于具有多样化种族和种族的人群的癌症发展和进展的环境，生活方式和遗传因素，并利用知识来制定策略和计划来降低癌症风险并延长患者的生存。为了实现这一目标，EPI计划的成员将重点放在研究重点的3个领域，这些研究重点是种族/种族多样性的总体主题。这3个研究领域是1）遗传敏感性，2）营养和生活方式以及3）传染剂。在每个研究重点的每个领域，该计划都有多个当前和未来的目标。为了实现这些目标，该计划已建立和维持有价值的资源，包括夏威夷肿瘤注册中心，多民族队列，HPV队列，大肠癌家庭注册表和残留组织储存库。使用这些独特的资源，该计划成员完成了大量研究项目，其中包括许多分子和遗传流行病学研究，这些研究涉及单核苷酸多态性在遗传易感性癌症中的作用。已经研究了许多遗传多态性，因为它们与几种主要癌症的风险相关，包括乳房，前列腺，结肠，肺，子宫内膜和卵巢。这些研究为我们对癌症遗传学和易感性的理解做出了重大贡献。 EPI在该领域的关注将继续扩展到包括更多遗传特征，它们与环境和生活方式因素的相互作用以及它们参与肿瘤进展和治疗反应。 EPI计划在癌症的营养和生活方式研究领域也已经取得了重要成就。多民族队列最初主要集中在饮食和营养上。已经针对该队列进行了许多研究，以了解不同种族的癌症的饮食和营养。基因 - 核心相互作用和与生活方式相关的表观遗传变化将是该领域的新焦点。 EPI教师的HPV研究还产生了有关病毒感染和癌症风险的宝贵信息。该领域的未来研究将集中于更具传染性的药物及其与癌症病因，检测和预防中表观遗传调节的相互作用。 EPI计划通过焦点小组，研究合作，教师培训，研讨会和其他联合活动与癌症中心的其他计划进行了重大互动。相互作用促进了良好的合作，促进癌症中心跨学科和翻译研究，以实现减轻夏威夷人中癌症负担的目标。