Cancer Prevention and Control

癌症预防与控制

基本信息

批准号：
8369387
负责人：
MICHELE CARBONE
金额：
$ 0.84万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8369387
关键词：
Adolescent Adoption Adult Alcohol consumption Alcohols Appointment Area Arts Behavior Behavior Therapy Behavioral Behavioral Research Behavioral Sciences Biological Biometry Burn injury Cancer Biology Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Control Research Cancer Etiology Carcinogens Cigarette Clinical Clinical Research Communities Community Health Dental Hygiene Discipline of Nursing Early Diagnosis Environmental Risk Factor Epidemiology Ethnic Origin Ethnic group Exposure to Faculty Family Practice Gender Genes Genomics Goals Grant Hawaii Health Sciences Humanities Incidence Individual Informatics Intervention Knowledge Life Style Malignant Neoplasms Medicine Mission Modeling Morbidity - disease rate Nuts Obesity Paper Peer Review Pharmacy facility Physical activity Population Population Sciences Prevention Primary Cancer Prevention Primary Prevention Process Public Health Publications Publishing Research Research Personnel Resource Sharing Risk Factors Risk Reduction Behavior Role Schools Science Secondary Prevention Secure Site Smoking Social Work Source Testing Tobacco Tobacco use Tobacco-Associated Carcinogen Translational Research Treatment Efficacy Underserved Population United States Universities Weight maintenance regimen Youth anticancer research biobehavior cancer health disparity cancer prevention cancer risk cigarette smoking college cost drinking experience health disparity high risk improved innovation medical schools meetings member mortality movie nutrition obesity management prevent programs psychosocial racial and ethnic social socioeconomics survivorship tertiary prevention theories

项目摘要

Hawai'i is the single most promising site in the United States that can enhance the depth and breath of our knowledge on how to prevent and reduce cancer-related disparities among multiple racial/ethnic, socioeconomic, and geographically isolated groups. The Cancer Prevention and Control Program (P&C) conducts research that aims to reduce cancer-related disparities in the people of Hawai'i and Pacific region, areas with remarkable cultural and ethnic diversity. Faculty research uniquely focuses on the primary prevention of cancer by advancing behavioral and bio-behavioral research to reduce modifiable lifestyle risk factors in healthy and high-risk youth and adult populations in community and clinical settings. P&C's two major themes are 1) to elucidate mechanisms by which intrapersonal, interpersonal, and societal/community level factors influence tobacco, alcohol, and betel nut use; nutrition; physical activity; and obesity, and 2) to test theoretically-grounded behavioral interventions among multiethnic youth and adults. Recent advances help to identify mechanisms by which the depictions of smoking and drinking in movies influence adolescent cigarette and alcohol use; elucidate the role of ethnicity in tobacco use and the roles of dual process theory and the Transtheoretical Model (TTM) in cigarette smoking among multiethnic populations; Identify gene-behavioral factors that influence cigarette smoking; unravel the applicability of TTIVI to physical activity behaviors and among multiethnic populations; provide racial/ethnic and gender context to the problem of obesity and weight management; and illustrate the efficacy of interventions grounded in a socio-ecological framework to increase physical activity and other lifestyle risk factors. Research/community capacity and dissemination grants increase translational capacity and the reach and adoption of risk reduction behaviors among multiethnic populations. Our newly restructured Program includes 10 full and 8 associate faculty members who bring diverse disciplinary expertise that helps the Program to accelerate scientific discoveries in primary cancer prevention, behavioral and biobehavioral research, and addictive carcinogens science. Faculty members hold appointments in the University of Hawai'i Cancer Center, the University of Hawai'i Schools of Social Work, Nursing and Dental Hygiene, Pharmacy, Arts and Humanities, and the John A. Burns School of Medicine Departments of Family Medicine and Community Health, Medicine, and Public Health Sciences. Complimentary expertise includes 12 members with expertise in primary cancer prevention, 12 faculty with expertise in the behavioral and bio-behavioral sciences; 17 researchers engaged in health disparities research; and 8 members with long-standing experience in addictive carcinogens science. To accelerate progress in reducing cancer, P&C faculty members interact with the UHCC Epidemiology and Cancer Biology Programs, faculty from other colleges and schools of the University of Hawai'i, and faculty outside of the University of Hawai'i. The activities of the P&C Program rely on several UHCC shared resources including Biostatistics and Informatics, Genomics, Nutrition, and the Clinical and Translational Research Sciences and interactions through workgroups, seminars, and meetings. P&C faculty members have successfully competed to secure S7.2M in direct and $12.7M in total NCI-approved cancer research dollars. An additional 1.4M in direct and 1.5 M in total costs were secured from other peer-reviewed sources. Between 2005 and 2011, P&C members published 218 peer-reviewed cancer-focused papers. The percentage of collaborative publications increased from 25.2% in 2005 to 36% in 2011.

夏威夷是美国最有前途的单位，可以增强我们如何预防和减少多种种族/种族，社会经济和地理孤立群体之间与癌症相关的差距的深度和呼吸。癌症预防和控制计划（P＆C）进行研究，旨在减少夏威夷和太平洋地区人民的癌症相关差异，该地区具有显着的文化和种族多样性。教师研究独特地通过推进行为和生物行为研究，以减少在社区和临床环境中健康和高风险的青年和成人人群中的可修改生活方式危险因素，通过推进行为和生物行为研究的主要预防癌症。 P＆C的两个主要主题是1）阐明人际，人际和社会/社区层面因素影响烟草，酒精和槟榔的机制；营养;体育锻炼；和肥胖，以及2）在理论上测试多种族青年和成人的行为干预措施。最近的进步有助于确定电影中吸烟和饮酒影响青少年香烟和饮酒的机制；阐明种族在烟草使用中的作用以及双重过程理论的作用以及跨理论模型（TTM）在多种族种群中吸烟中的跨理论模型（TTM）；确定影响吸烟的基因行为因素；揭示TTIVI对体育活动行为以及多种族人口的适用性；为肥胖和体重管理问题提供种族/种族和性别背景；并说明了基于社会生态框架以增加体育活动和其他生活方式风险因素的干预措施的功效。研究/社区的能力和传播补助金可以增加转化能力，以及多种族人口中降低风险行为的影响和采用。我们新重组的计划包括10名完整和8位副教授，他们带来了多样化的纪律专业知识，可帮助该计划加快预防原发性癌症，行为和生物行为研究以及成瘾性致癌科学方面的科学发现。教职员工在夏威夷大学癌症中心，夏威夷大学社会工作，护理和牙科卫生，药学，艺术和人文学院以及约翰·A·伯恩斯医学院的家庭医学和社区健康，医学和公共卫生科学学院任命。免费专业知识包括12名具有初级癌症专业知识的成员，12名具有行为和生物行为科学专业知识的教师； 17个研究人员从事健康差异研究；和8位成员在上瘾的致癌科学方面拥有长期经验。为了加快减少癌症的进步，P＆C教师与UHCC流行病学和癌症生物学计划，夏威夷大学其他学院和学校的教职员工以及夏威夷大学以外的教职员工进行互动。 P＆C计划的活动依赖于几种UHCC共享资源，包括生物统计学和信息学，基因组学，营养以及通过工作组，研讨会和会议的临床和转化研究科学以及互动。 P＆C教职员工已成功竞争，以直接获得720万S的SNES SEN，总计为NCI批准的癌症研究美元1,270万美元。其他同行评审的来源还获得了另外140万个直接成本和1.5 m的总成本。在2005年至2011年之间，P＆C成员发表了218份以同行评审的癌症论文。合作出版物的百分比从2005年的25.2％增加到2011年的36％。