MMRRC Annual Meeting

MMRRC年会

基本信息

批准号：
8061271
负责人：
LEAH RAE B DONAHUE
金额：
$ 1.8万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-02-03 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8061271
关键词：
Address Affect Animal Model Archives Atlases Beta Cell Biological Preservation Biomedical Research California Cellular biology Collection Communication Communities Country Defect Development Disease ES Cell Line Effectiveness Ensure Equipment and supply inventories Ethylnitrosourea Funding Gene Expression Genes Genetically Engineered Mouse Genomics Goals Growth Human Human Resources Individual Informatics Institution Life Link Maine Metric Missouri Modeling Monitor Mouse Strains Mus Mutagenesis Mutant Strains Mice Mutation National Center for Research Resources Nature Nervous system structure Neurosciences North Carolina Organizational Policy Orthologous Gene Pathology Performance Persons Pharmaceutical Preparations Pigmentation physiologic function Policies Prevention strategy Principal Investigator Request for Proposals Research Research Personnel Research Support Resource Sharing Resources Safety Scientist Services Stream Teleconferences Testing The Jackson Laboratory Therapeutic Time U-Series Cooperative Agreements United States National Institutes of Health Universities biological systems comparative cost cost effective genome sequencing human disease meetings member model development mouse model mutant mutant mouse model operation organizational structure pre-clinical research programs repository stem cell technology success symposium

项目摘要

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value-added services to the biomedical research community. The MMRRC Program is supported by the NIH National Center for Research Resources (NCRR) and is organized through U42 cooperative agreements that administratively and operationally link the NCRR with 4 repositories located strategically in the Western (University of California-Davis), Central (University of Missouri), and Eastern (University of North Carolina-Chapel Hill and The Jackson Laboratory) USA, and an Informatics, Coordination and Service Center (ICSC; The Jackson Laboratory). This organizational structure ensures the protection, preservation, and availability of mutant mouse strains for research by academic and, as of 2010, for-profit investigators and enables NIH-funded researchers to meet the NIH resource-sharing requirement in a convenient and cost-effective manner. In its 11th year of operation, the MMRRC (www.mmrrc.org), as of 1 April 2010, has grown to an inventory of 2,234 mutant and genetically engineered mouse models maintained either as live colonies or cryopreserved germplasm, and 27,627 ES cell lines. In 2010, the MMRRC program was expanded by adding The Jackson Laboratory, an internationally recognized mouse resource center, as the fourth MMRRC repository. During its first 10 years, the MMRRC's original 3 repositories together filled over 6,629 orders from 2,170 investigators at over 1,430 institutions worldwide. Over 325 investigators and 10 major NIH-funded resource model development programs have preserved their strains and ES cell lines using the MMRRC. A multi-institutional, regionally distributed program of this size requires frequent communication. Monthly teleconferences are used to coordinate operations; however, annual meetings are critical to provide sufficient time and face-to-face interactions to discuss long-term strategies to ensure that the MMRRC Program continues to serve the rapidly evolving needs of the scientific community. These annual meetings also are invaluable to address numerous operational, organizational, and policy issues and develop strategies to continue to enhance the effectiveness of the MMRRC program. Therefore, this proposal requests $18,030 to support the 9th Annual MMRRC Meeting in May 2011 at The Jackson Laboratory in Bar Harbor, Maine. This meeting will bring together the Principal Investigators and other key personnel from each of the 4 repositories and the ICSC, NCRR and other NIH Program staff. The goals of this meeting will be to 1) critically and objectively review and assess MMRRC operational and performance metrics, 2) discuss research goals and accomplishments of individual centers, and 3) develop strategies for meeting ongoing and evolving needs of the scientific research community using mouse resources. The continued growth and success of the MMRRC Program has shown the value of these annual meetings. ) PUBLIC HEALTH RELEVANCE (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides invaluable resources to the biomedical research community: genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value- added services. Mouse models for human disorders and for basic biomedical research are critical to understand biological systems affected by human diseases. With a sequenced genome and increasingly sophisticated stem cell technologies to manipulate it, the mouse remains the most powerful model organism for biomedical research. Genetically engineered mouse models with mutations in orthologs of human genes are critical for translational and pre clinical research. They enable scientists to understand the causes, pathologies and progression of human diseases so that prevention strategies or therapeutics for these diseases can be developed. In addition, therapies or drugs can be tested on mouse models prior to human trials to assess efficacy and safety. Communication among MMRRC components is critical for its continued success in meeting evolving needs of biomedical research community.

描述（由申请人提供）：突变小鼠区域资源中心（MMRRC）是NIH支持的主要国家突变体小鼠档案和分布财团，可提供遗传改变的小鼠，冷冻保存材料，胚胎茎（ES）细胞系，技术支持和技术支持，技术支持和技术支持生物医学研究界的增值服务。 MMRRC计划得到了NIH国家研究资源中心（NCRR）的支持，并通过U42合作协议组织，该协议在行政和操作上与NCRR在西部（加利福尼亚戴维斯大学）的战略性上将NCRR与4个存储库联系起来，密苏里州）和美国东部（北卡罗来纳大学 - 教堂山和杰克逊实验室），以及信息学，协调与服务中心（ICSC；杰克逊实验室）。这种组织结构可确保对学术研究人员进行的研究，并截至2010年的研究人员的研究，并使NIH资助的研究人员能够以方便且具有成本效益的方式满足NIH资源共享需求方式。截至2010年4月1日，MMRRC（www.mmrrc.org）在其运营的第11年中，已经成长为2,234个突变体和基因工程的鼠标模型的库存，并以活菌落或冷冻保存的种质和27,627 ES Cell Lines维持。 2010年，通过添加国际公认的鼠标资源中心杰克逊实验室（Jackson Laboratory）作为第四个MMRRC存储库来扩展MMRRC计划。在最初的10年中，MMRRC的最初3个存储库共同填写了来自全球1,430多家机构的2,170名调查人员的6,629多个订单。超过325位研究人员和10名主要NIH资助的资源模型开发计划已使用MMRRC保留了其菌株和ES细胞系。这种大小的多机构区域分布的程序需要频繁的通信。每月电信用于协调运营；但是，年度会议对于提供足够的时间和面对面的互动至关重要，以讨论长期策略，以确保MMRRC计划继续满足科学界快速发展的需求。这些年度会议也非常宝贵，可以解决众多运营，组织和政策问题，并制定策略以继续提高MMRRC计划的有效性。因此，该提案要求$ 18,030支持2011年5月在缅因州巴港的杰克逊实验室举行的第9届MMRRC会议。这次会议将从四个存储库中的每个存储库以及ICSC，NCRR和其他NIH计划工作人员中汇集主要调查人员和其他关键人员。这次会议的目标将是1）批判性，客观地审查和评估MMRRC运营和绩效指标，2）讨论单个中心的研究目标和成就，3）制定策略，以满足使用科学研究社区的持续和不断发展的需求鼠标资源。 MMRRC计划的持续增长和成功表明了这些年度会议的价值。）公共卫生相关性（由申请人提供）：突变鼠标区域资源中心（MMRRC）是NIH支持的主要国家突变体鼠标档案和分布财团，为生物医学研究社区提供了宝贵的资源：遗传改变的小鼠，冷冻保留材料，胚胎茎，胚胎茎（ES）单元线，技术支持和增值服务。人类疾病和基本生物医学研究的小鼠模型对于了解受人类疾病影响的生物系统至关重要。通过测序的基因组和越来越复杂的干细胞技术来操纵它，小鼠仍然是生物医学研究中最强大的模型生物。在人类基因直系同源物中具有突变的基因工程小鼠模型对于翻译和临床前研究至关重要。它们使科学家能够理解人类疾病的原因，病理和进展，以便可以开发出针对这些疾病的预防策略或治疗学。此外，在人体试验之前，可以在小鼠模型上对疗法或药物进行测试，以评估功效和安全性。 MMRRC组件之间的沟通对于它在满足生物医学研究社区不断发展的需求方面的持续成功至关重要。