Hematopoiesis

造血作用

基本信息

批准号：
8121912
负责人：
ANDREW D ROBERTSON
金额：
$ 1.3万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8121912
关键词：
Academia Adult Aging Area Attention Biological Models Biology Blood Blood Cells Cardiovascular Diseases Cause of Death Cell Communication Cell Fate Control Cells Cellular biology Cessation of life Clinical Collaborations Data Development Diabetes Mellitus Disease Embryo Employee Strikes Endothelium Faculty Feedback Functional disorder Funding Funding Agency Future Genetic Grant Growth Growth Factor Health Hematological Disease Hematology Hematopoiesis Hematopoietic Hematopoietic System Human Imagery In Situ Individual Industry Intervention Investigation Journals Knowledge Lead Light Malignant Neoplasms Mentorship Modeling Molecular Montana Occupations Organ Organism Outcome Pathology Pattern Physicians Policy Maker Process Regulation Request for Proposals Research Research Personnel Role Science Scientist Signal Transduction Societies Solid Staging Stroke System Time Tissues Training Transcriptional Regulation age related base career career development catalyst cell motility cell type cellular imaging fetal gene function human disease in vivo insight meetings multidisciplinary new technology patient advocacy group regenerative stem cell biology symposium tool

项目摘要

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Hematopoiesis, organized by David Traver, Amy J. Wagers and Emmanuelle Passegui, which will be held in Big Sky, Montana from March 27 - April 1, 2011. As a paradigmatic model of developmental and regenerative biology, studies of the hematopoietic system have been critical in establishing fundamental principles in growth factor signaling, transcriptional regulation, organ patterning and stem cell biology. Now, with new and emerging knowledge, we are beginning to develop a true molecular understanding of the mechanisms by which blood cells are created and maintained, and how their function may be perturbed in the context of hematopoietic deficiency and malignancy. In addition, sophisticated embryological studies have finally documented the existence of bipotential hemogenic endothelium in developing organisms, and striking technological advances in in vivo imaging and cell identification strategies have provided our first direct visualization of blood cell formation in situ. All of this has indicated the key importance of cell migration and interaction with discrete niches in the direction of cell fate and function. Finally, when turned to the study of blood diseases, these tools have provided unexpected insights into the microenvironmental controls that regulate hematopoietic (dys)function during aging and malignancy. In light of these exciting developments, it is clear that the time has come to again bring together hematopoiesis researchers to facilitate and accelerate the exchange of new knowledge and ideas. This meeting will include a diverse group of scientists studying hematopoiesis with new technologies and complementary model systems. Speakers have been invited from all career stages, and talks will focus on current findings, emerging opportunities, and immediate challenges within the field. We expect this meeting to serve as a catalyst to develop new ideas and collaborations, and to enhance and encourage the creative and interactive science that will continue to push forward discoveries in this important area of research.

描述（由申请人提供）：该提案请求支持Keystone专题讨论会议，标题为“造血症”，由David Traver，Amy J. Wagers和Emmanuelle Passegui组织，该组织将于2011年3月27日至4月27日在蒙大拿州举行，作为2011年3月27日的蒙大拿州。生长因子信号传导，转录调控，器官模式和干细胞生物学。现在，有了新的和新兴的知识，我们开始对创建和维持血细胞的机制进行真正的分子理解，以及在造血缺乏和恶性肿瘤的背景下如何扰动其功能。此外，复杂的胚胎学研究最终证明了在发育生物体中存在双性血液生成内皮的存在，并且在体内成像和细胞识别策略中的惊人技术进步提供了我们首次直接可视化血细胞形成的原位。所有这些都表明了细胞迁移和与离散壁ni的相互作用在细胞命运和功能方向上的关键重要性。最后，当转向血液疾病的研究时，这些工具为调节衰老和恶性肿瘤期间调节造血（DYS）功能的微环境控制提供了意想不到的见解。鉴于这些令人兴奋的发展，很明显，现在是时候再次将造血研究人员汇集在一起，以促进和加速新知识和思想的交流。这次会议将包括一群通过新技术和互补模型系统研究造血的科学家。演讲者受到所有职业阶段的邀请，谈判将重点关注当前的发现，新兴的机会以及该领域的近期挑战。我们希望这次会议成为催化剂，以发展新的想法和合作，并增强和鼓励创造性和互动科学，这些科学将继续推动这一重要领域的发现。