NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses

NK 和 NKT 细胞生物学：先天反应的特异性和冗余

• 批准号: 8006107
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006107
• 关键词: Address; Autoimmunity; Biological; Cell Shape; Cells; Cellular biology; Clinic; Collaborations; Colorado; Development; Disease; Immune; Immune response; Infection; Inflammatory; International; Lead; Learning; Ligands; Lymphocyte; Lymphocyte Subset; Malignant Neoplasms; Mediator of activation protein; Natural Immunity; Natural Killer Cells; Organ; Population; Process; Regulation; Request for Proposals; Role; Scanning; Signal Transduction; Specificity; Text; abstracting; cell type; knowledge base; meetings; pathogen; response; symposium

DESCRIPTION (provided by applicant): Abstract PI: ROBERTSON, ANDREW D Project: 1R13AI091292-01 Title: NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses Accession Number: 3255538 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This proposal requests support for a Keystone Symposia meeting entitled NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses, organized by James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg, which will be held in Breckenridge, Colorado from January 9 - 14, 2011. Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development; NK/NKT cell- ligand recognition; NK/NKT activation and "crosstalk"; and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This "confrontation" between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators. In fact, this meeting is the only international meeting that brings together the world's leading experts on NK and NKT cell biology in a forum that is uniquely devoted to understanding the "crosstalk" between these two innate lymphocyte subsets. This meeting will address many questions related to fundamental mechanisms involved in the activation and regulation of immune responses to infectious pathogens. Moreover, understanding NK and NKT cell biology has broad implications, and therefore multiple, diverse plenary sessions will be devoted to the study of these two cell types, encompassing everything from signaling and development to whole organ studies of immune responses in the context of infection, autoimmunity and cancer.

描述（由申请人提供）： 抽象的 PI：ROBERTSON, ANDREW D 项目：1R13AI091292-01 标题：NK 和 NKT 细胞生物学：先天反应的特异性和冗余 登录号：3255538 ================= 注意：此摘要是从申请中提取的，未经 SRA 验证。当申请扫描过程出现问题时，提取的文本可能不正确或不完整。 ================= 该提案请求支持由 James P. Di Santo、Eleanor M. Riley 和 Mitchell Kronenberg 组织的题为 NK 和 NKT 细胞生物学：先天反应的特异性和冗余的 Keystone 研讨会，该会议将于 1 月 9 日在科罗拉多州布雷肯里奇举行- 2011 年 14 日。在过去的十年里，我们在先天免疫方面的知识库已经爆炸式增长，我们对先天免疫机制的理解很快就会影响到诊所。尽管如此，关于 NK 细胞和 NKT 细胞如何塑造先天性和适应性免疫反应，我们仍有很多东西需要了解。本次会议将汇集 NK 和 NKT 细胞专家，讨论他们在 NK/NKT 开发等主题上的最新前沿成果，以解决与这两种专门的先天淋巴细胞群的生物学作用相关的问题； NK/NKT细胞-配体识别； NK/NKT 激活和“串扰”；以及 NK/NKT 细胞在炎症性疾病、感染和癌症中作为免疫反应的效应器和调节器的作用。 NK 细胞和 NKT 细胞生物学家之间的这种“对抗”应该会促进一个关于 NK/NKT 细胞反应的特异性和冗余性的讨论和辩论的活跃论坛，并有望带来新的合作，以帮助加深我们对这些细胞的生物学作用的理解。重要的先天调节因子。事实上，本次会议是唯一一次将世界领先的 NK 和 NKT 细胞生物学专家聚集在论坛上的国际会议，该论坛专门致力于了解这两种先天淋巴细胞亚群之间的“串扰”。这次会议将讨论与感染性病原体免疫反应的激活和调节所涉及的基本机制相关的许多问题。此外，了解 NK 和 NKT 细胞生物学具有广泛的意义，因此多个不同的全体会议将致力于研究这两种细胞类型，涵盖从信号传导和发育到感染背景下免疫反应的整个器官研究的所有内容，自身免疫和癌症。