2011 CSHL Yeast Cell Biology Conference

2011年CSHL酵母细胞生物学会议

• 批准号: 8122810
• 负责人: DAVID J. STEWART
• 金额: $ 0.5万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122810
• 关键词: Actins; Alcohols; Animals; Area; Attention; Beds; Biogenesis; Bioinformatics; Biological; Biological Models; Biological Process; Biology; Bread; Candida albicans; Caring; Cell Cycle; Cell Cycle Regulation; Cell division; Cell physiology; Cells; Cellular Structures; Cellular biology; Child; Chromosome Structures; Chromosomes; Collaborations; Communication; Communities; Complement; Computer Simulation; Cytoskeletal Modeling; Cytoskeleton; DNA; Data; Development; Discipline; Disease; Drug Industry; Educational process of instructing; Elements; Ensure; Environment; Eukaryotic Cell; Event; Faculty; Fertilization; Fission Yeast; Fostering; Funding; Future; Genomics; Goals; Health; Human; Individual; Infectious Skin Diseases; Institution; International; Knowledge; Laboratories; Lead; Learning; Life; Membrane Protein Traffic; Methodology; Microscopy; Microtubules; Minority; Molecular; Nuclear; Oral; Organelles; Organism; Participant; Pathway interactions; Physiology; Play; Postdoctoral Fellow; Proteins; Proteomics; Regulation; Relative (related person); Research; Research Institute; Research Personnel; Resource Sharing; Resources; Saccharomyces cerevisiae; Saccharomycetales; Scientist; Senior Scientist; Series; Services; Shapes; Signal Transduction; Signal Transduction Pathway; Structure; Students; Study models; System; Techniques; Technology; Testing; Tissues; Training; Training and Education; Vascular Plant; Woman; Work; Yeasts; abstracting; base; biological research; career; cell type; frontier; fungus; graduate student; insight; interest; meetings; member; next generation; posters; programs; response; role model; skills; success; symposium; tool; Actins; Alcohols; Animals; Area; Attention; Beds; Biogenesis; Bioinformatics; Biological; Biological Models; Biological Process; Biology; Bread; Candida albicans; Caring; Cell Cycle; Cell Cycle Regulation; Cell division; Cell physiology; Cells; Cellular Structures; Cellular biology; Child; Chromosome Structures; Chromosomes; Collaborations; Communication; Communities; Complement; Computer Simulation; Cytoskeletal Modeling; Cytoskeleton; DNA; Data; Development; Discipline; Disease; Drug Industry; Educational process of instructing; Elements; Ensure; Environment; Eukaryotic Cell; Event; Faculty; Fertilization; Fission Yeast; Fostering; Funding; Future; Genomics; Goals; Health; Human; Individual; Infectious Skin Diseases; Institution; International; Knowledge; Laboratories; Lead; Learning; Life; Membrane Protein Traffic; Methodology; Microscopy; Microtubules; Minority; Molecular; Nuclear; Oral; Organelles; Organism; Participant; Pathway interactions; Physiology; Play; Postdoctoral Fellow; Proteins; Proteomics; Regulation; Relative (related person); Research; Research Institute; Research Personnel; Resource Sharing; Resources; Saccharomyces cerevisiae; Saccharomycetales; Scientist; Senior Scientist; Series; Services; Shapes; Signal Transduction; Signal Transduction Pathway; Structure; Students; Study models; System; Techniques; Technology; Testing; Tissues; Training; Training and Education; Vascular Plant; Woman; Work; Yeasts; abstracting; base; biological research; career; cell type; frontier; fungus; graduate student; insight; interest; meetings; member; next generation; posters; programs; response; role model; skills; success; symposium; tool

DESCRIPTION (provided by applicant): Research in the past decade has spurred tremendous progress in our understanding of molecular mechanisms that underlie cell function. Advances have come from multiple cell types and organisms. Notably, yeast systems often have been at the forefront in the discovery of new proteins, pathways, structures, and in mechanistic insights. Despite its existence as a unicellular organism, yeast research has also revealed unexpected insights into the physiology of multicellular organisms and the functions of specialized tissues. Yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and technologies. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will create a premier forum for the discussion and exchange of cutting-edge discoveries about the internal functions of eukaryotic cells. The program will include eight sessions covering a wide range of topics in cell biology including membrane trafficking, cytoskeleton, the cell cycle, polarity, chromosomes, nuclear organization, and signaling, with a focus on higher order regulation that integrates these diverse events. Each session will be led by two outstanding and well-known investigators in the relevant area. With the exception of short talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other junior investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The meeting will serve to provide a stimulating environment for the free flowing discussion of some of the most exciting data and concepts at the frontiers of knowledge in cell biology. Given the rapid pace of developments in the field, this meeting presents an exciting opportunity for participants to learn about recent breakthroughs that will be relevant to their own research both in yeast and in other systems. The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond yeast cell biology, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights that impact the physiologies of all life forms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions. PUBLIC HEALTH RELEVANCE: Yeast is probably best known for its ability to make bread or alcohol, or perhaps for its ability to cause skin infections and worse. But this humble single-celled organism has become a mainspring of modern biology, because it shares the same principal components and structure as cells of higher plants and animals. This has made yeast a widely studied model for biologists to explore a variety of cellular processes, including how cells grow and divide, how they organize their DNA and chromosomes, how they maintain and organize their organelles, how they move and change shape in response to their environment, and how the sense and respond to external change. In fact work over the last three decades has shown again and again that even at the molecular level, yeast cells share many components and details with their more "sophisticated" cousins. The relative simplicity of yeast means that a huge body of knowledge about its biology has been accumulated, and many molecular tools and approaches were first developed and are at their most complicated in the analysis of these cells. It is also becoming more evident just how much apparently unrelated functions are actually highly coordinated and orchestrated, requiring a more holistic exploration of cell function to understand how individual parts work together. Because of the implications on biology in other systems, including in human health and disease, yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and techniques. This proposed meeting series, long the forum for scientists to present their latest unpublished ideas, aims to keep the yeast system as an important and useful model system by promoting rapid dissemination of advances and open communication between experts in various disciplines. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will continue a premier forum for the discussion and exchange of cutting-edge discoveries, attract and allow the active participation of a diverse group of scientists, and will help to accelerate biological research with real and well-proven implications for human well being.

描述（由申请人提供）：在过去的十年中，研究在我们对基于细胞功能的分子机制的理解中刺激了巨大的进步。进展来自多种细胞类型和生物。值得注意的是，在发现新蛋白质，途径，结构和机械见解中，酵母系统通常一直处于最前沿。尽管它是单细胞生物的存在，但酵母研究还揭示了对多细胞生物生理学和专用组织功能的意外见解。酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统通过作为新概念和技术的测试床而对较大的研究社区至关重要。关于酵母细胞生物学的会议系列的智力优点（2011年，2013年和2015年）是，它将创建一个首要论坛，以讨论和交流真核细胞的内部功能的尖端发现。该计划将包括八个课程，涵盖细胞生物学的广泛主题，包括膜运输，细胞骨架，细胞周期，极性，染色体，核组织和信号传导，重点是整合这些多样性事件的高阶调节。每个会议将由相关领域的两个杰出且著名的调查员领导。除了会议主席发表的简短会谈外，所有要提交的会谈和海报将从提交的摘要中选择，并且大多数会谈将由学生，博士后研究员和其他初级调查员进行。预计将有275多名科学家参加。其中，一半以上可能是研究生和博士后研究员。这次会议将提供一个刺激的环境，以自由讨论细胞生物学知识前沿中一些最令人兴奋的数据和概念。鉴于该领域的发展速度迅速，这次会议为参与者提供了一个令人兴奋的机会，可以了解最近的突破，这些突破与他们在酵母和其他系统中的研究都相关。提出的活动的更广泛影响是多方面的。首先，它们包括对酵母细胞生物学以外的其他领域的科学含义，因为该领域的发现将继续促进影响所有生命形式生理的基本发现和见解的迅速步伐。其次，它们还包括教育要素，培训，资源共享以及互动与协作的机会。特别是，会议将提供：（i）为初级科学家提供培训机会，以促进演讲技巧的发展以及整体的科学质量和分析性严格； （ii）一个亲密的环境，将在所有职业层面上促进科学家之间有意义的科学互动； （iii）在多个研究和教育机构的多个阶层之间传播知识； （iv）分享资源和信息的资源； （v）启动合作的机会，这些机会可以使来自较小实验室的科学家和/或主要是本科（教学）机构的科学家受益，而本科机构的资源可能比主要研究机构的科学家更少，对尖端技术的机会更少。 公共卫生相关性：酵母可能以制造面包或酒精的能力或可能引起皮肤感染和恶化的能力而闻名。但是，这种不起眼的单细胞生物已成为现代生物学的主流，因为它具有与较高动植物的细胞相同的主要成分和结构。这使酵母成为生物学家的广泛研究模型，以探索各种细胞过程，包括细胞生长和分裂，如何组织其DNA和染色体，如何维持和组织细胞器，如何响应环境以及如何对环境以及对外部变化的感觉和反应方式变化。实际上，在过去的三十年中，工作中一次又一次地表明，即使在分子水平上，酵母细胞也具有许多成分和细节，其“复杂”的表亲。酵母的相对简单性意味着已经积累了有关其生物学的大量知识，并且首先开发了许多分子工具和方法，并且在分析这些细胞时最为复杂。它也越来越明显地显然是无关的功能实际上是高度协调和精心策划的，需要对细胞功能进行更全面的探索，以了解单个部分如何共同工作。由于在其他系统中对生物学的影响，包括在人类健康和疾病中，酵母细胞生物学仍然是一个充满活力的研究领域，并且通过作为新概念和技术的测试床，对较大的研究界对较大的研究社区至关重要。这个拟议的会议系列是科学家的长期论坛，以提出最新的未发表思想，旨在通过促进各种学科专家之间的进步和开放沟通来促进进步和开放沟通，以使酵母系统成为一个重要且有用的模型系统。关于酵母细胞生物学会议系列的智力优点（2011年，2013年和2015年）是，它将继续一个主要论坛，讨论和交流尖端发现，吸引并允许一群多样的科学家的积极参与，并有助于加快生物学研究，对人类的真实和良好的含义。