POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

慢病毒感染猕猴的暴露后监测

• 批准号: 8172754
• 负责人: DAVID M ANDERSON
• 金额: $ 46.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172754
• 关键词: Animals; Blood; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Evaluation; Funding; Grant; HIV; Institution; Macaca; Monitor; Pathogenesis; Research; Research Personnel; Resources; SIV; Serologic tests; Serum; Source; Subfamily lentivirinae; T-Lymphocyte Subsets; United States National Institutes of Health; Vaccines; Viral; design; immunosuppressed

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to act as a holding and resource project for animals that have been infected with SIV or HIV that are no longer required on the original project. The animals will be maintained in an ABSL-2/3 facilities. They will be monitored clinically to help define the natural pathogenesis of the disease. The animals may be reassigned to other projects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目旨在作为原项目不再需要的已感染 SIV 或 HIV 的动物的饲养和资源项目。这些动物将被饲养在 ABSL-2/3 设施中。将对它们进行临床监测，以帮助确定疾病的自然发病机制。这些动物可能会被重新分配到实验药物评估、发病机制研究、疫苗研究或需要免疫抑制和/或 SIV/HIV 病毒血症动物的研究中的其他项目。 每 2-3 个月抽取一次血液进行病毒分离、血清学、CBC、血清化学和 T 细胞亚群分析。